Clinical characteristics, complications and prognosis of seventy-nine measles cases

Amaç: Kızamığın çocuklarda yaş dağılımını, klinik ve laboratuar özelliklerini, radyolojik bulgularını, yan etkilerini ve prognozu değerlendirmek amaçlandı. Gereç ve Yöntem: Klinik olarak kızamık tanısı konulan ve kızamık IgM antikor mikroELISA yöntemi ile de tanısı kesinleşen olgular kızamığın yan etkileri (alt solunum yolu enfeksiyonu, orta kulak iltihabı, ensefalit) açısından ayrıntılı olarak değerlendirildi. Bulgular: Yetmiş dokuz olgunun yaşları 1–180 ay arasında değişmekteydi. Hastalığın şiddeti yaşın küçük olması (p

Yetmişdokuz kızamık olgusunda klinik özellikler, komplikasyonlar ve prognoz

Aim: To investigate the age distribution, clinical presentations, laboratory and radiological findings, complications and prognosis of measles in children. Materials and Methods: The children with the clinical diagnosis of measles which was confirmed by a sensitive enzyme immunoassay for measles IgM antibody were evaluated comprehensively aspect to complication of measles (i.e. pneumonia, otitis media, encephalitis). Results: The ages of the 79 patients with measles ranged from 1 to 180 months. The severity of the disease was significantly correlated with the younger age (p

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  • 1. Maldonado YA. Rubeola virus (measles and subacute sclerosing panencephalitis). In: Long SS, Pickering LK, Prober LG (eds), Principles and Practice of Pediatric Infecrious Diseases. 2nd. edition. Churchill Livinstone Inc. 2003pp; 1148-1155. 2. Smyth A. Pneumonia due to viral and atypical organisms and their sequelae. Br Med Bull 2002; 61:247-262. 3. Chalmers I. Why we need to know whether prophylactic antibiotics can reduce measles-related morbidity. Pediatrics 2002; 2: 312-315. 4. Hartter HK, Oyedele OI, Dietz K, et al. Placental transfer and decay maternally acquired antimeasles antibodies in Nigerian children. Pediatr Infect Dis J 2000; 19:635-641. 5. Ibrahim SA, Mustafa OM, Mukhtar MM, et al. Measles in suburban Khartoum: an epidemiological and clinical study. Trop Med Int Health 2002; 5:442-449. 6. Marufu T, Siziya S, Tshimanga M, et al. Factors associated with measles complication in Gweru, Zimbabwe. East Afr Med J 2001; 3:135-138. 7. Quiambao BP, Gatchalian SR, Halonen P, et al. Coinfection is common in measles-associated pneumonia. Pediatr Infect Dis J 1998; 17:89-93. 8. Kaplan LJ, Daum RS, Smaron M, et al. Severe measles in immunucompromised patients. J Am Med Assoc 1992; 267:1237-1241. 9. Acute respiratory infections in children: case management in small hospitals in developing countries. Programme for the control of ARI. Geneva: World Health Organization, 1988. 10. Gunaratne PS, Ranjendran T, Tilakaratne S. Neorological complications of measles. Ceylon Med J 2000; 2:48-50. 11. El-Far F, Sztajnbok J, Marotto PC, et al. Meningoencephalitis in the acute phase of measles. Report of 6 cases. Arq Neuropsiquiatr 2000; 58:136-140. 12. Kaninda AV, Legros D, Jatau M, et al. Measles vaccine effectivenes in standart and early immunization strategies, Niger, 1995. Pediatr Infect Dis J 1998; 17:1034-1039. 13. Caceres VM, Strebel PM. Factors determining prevalence of maternal antibody to measles virus throughout infancy: a review. Clin Infec Dis 2000; 31:110-119. 14. Gans H, Yasukawa L, Rinki M, et al. Immune responses to measles and mumps vaccination of infants at 6,9, and 12 months. J Infect Dis 2001; 184:817-826. 15. Kanra G, Ceyhan M: Elimination of maternal antibodies against measles. Turk J Pediatr 1991; 33:217-220. 16. Epidemiyoji Ünitesi, Viroloji Laboratuvar Şefliği. Yapılan saha çalışmalarındaki kızamık antikor dağılımları. AER 2002; 1:11. 17. Akramuzzaman SM, Cutts FT, Hossain MJ, et al. Measles vaccine effectiveness and risk factors for measles in Dhaka, Bangladesh. Bull WHO 2002; 80:776-782. 18. Mgone JM, Mgone CS, Duke T, et al. Control measures and the outcome of the measles epidemic of 1999 in the Eastern Highlands Province. P N G Med J 2000; 43:91-97. 19. Thakur JS, Ratho RK, Bhatia SP, et al. Measles outbreak in a Periurban area of Chandigargh: need for improving vaccine coverage and strengtening surveillance. Indian J Pediatr 2002; 69:33-37. 20. Van den Hof S, Conyn-van Spaendonck M, Van Steenbergen JE. Measles epidemic in The Netherlands, 1999–2000. J Infect Dis 2002; 186:1483-1486. 21. Van den Hof S, Smit C, Van Steenbergen JE, et al. Hospitalizations during a measles epidemic in the Netherlands, 1999–2000. Pediatr Infect Dis J 2002; 21:1146-1150. 22. Lertpiriyasuwat C, Kanlayanpotporn J, Deeying J, et al. Measles outbreak in an orphanage, Bangkok, Thailand, September- October 2000. J Med Assoc Thai 2002; 85:653-657. 23. Comittee on Infectious Diseases: Vitamin A treatment of measles. Pediatrics 1993; 91:1014-1015. 24. Griffin DE, Ward BJ, Esolen LM. Pathogenesis of measles virus infection: an hypothesis for altered immune responses. J Infect Dis 1994; 170 (Suppl 1):24-31. 25. Atabani SF, Byrnes AA, Jaye A, et al. Natural measles causes prolonged supression of interleukin–12 production. J Infect Dis 2001; 184:1-9. 26. Mustafa MM, Weitman SD, Winick NJ, et al. Subacute measles encephalitis in the young immunocompromised host: report of two cases diagnosed by polymerase chain reaction and treated with ribavirin and review of the literature. Clin Infect Dis 1993; 16:654-660. 27. Papadopoulu A, Theodoridou M, Syriopoulou V, et al. Hepatitis in children hospitalized with measles: the experience after a Greek epidemic. J Paediatr Child Health 2001; 1:55-57. 28. Okamura A, Itakura O, Yoshiko M, et al. Unusual presentation of measles giant cell pneumonia in a patient with Acquired Immunodeficiency Syndrome. Clin Infect Dis 2001; 32:57-58. 29. Kanra G, Çetin I, Akçören Z, et al. Giant cell pneumonia in a leukemic child in remission: a case report. Turk J Pediatr 2001; 43:338-341..