Sabite KACAR, Oktay KARATAN, Hüseyin TUTKAK

Amiloidozisde serum IL-6, IL-1alfa, TNFalfa düzeyleri

Primer amiloidozis, sekonder amiloidozis, Ailevi Akdeniz Ateşi'ne (FMF) bağlı amiloidozisli toplam 32 hasta ve 20 sağlıklı kontrol grubunda serum interlökin-6 (IL-6), interlökin l α (İL, l α), tümör nekrozis faktör α (TNF α) düzeylerini ELISA yöntemiyle tayin ettik. Tüm hastalarda IL-6 düzeyleri kontrol grubuna göre (p

Serum IL-6, IL-1alpha, TNFalpha levels in amyloidosis

Serum interleukin-6 (IL-6) interleukin-1a (IL-l α) tumor necrosis, factor a (TNF α) levels were determined by ELISA in all 32 patients suffering from primary amyloidosis, secondary amyloidosis and amyloidosis due to Familial Mediterranean Fever (FMF) and 20 healthy control group. Serum IL-6 levels in all patients were significantly higher than control group (p

PDF

___

1. Massry SC, Glassock RJ. Textbook of Nephrology. Baltimore 1989; Williams Wilkins: 745-746.
2. Glassock RJ, Cohen AS, Adler SG ve ark. Seconder glomerular diseases in The Kidney Brenner B, Rector F. 1991; 1280-1368.
3. Stone M. Amyloidosis: A final common pathvvay for protein deposition in tissues. Blood 1990; 75, 3: 531-545.
4. Finn A, Peter D, Gorevic MD.Clinical and biochemical correlates in primary amyloidosis. Am J Clin Pathol 1990; Sep. 353-355.
5. Glenner GG. Amyloid deposits and amyloidosis; the b fibrilloses. N Engl J Med 1980; 302: 1283-1292, 1333-1343.
6. Havvkins PN, Lavander JP, Pepys MB.Evaluation of systemic amyloidosis by scintgrapy vvith 123 l labeled serum amyloid P component. N Engl J Med 1990; Aug, 23:508-513.
7. Catchcart ES, Skinner M, Cohen AS.Immunogenicity of amyloid. Immunology 1971; 20: 945-954.
8. Nakayama T, Satomi S, Takashi U. Monitoring both serum amyloid protein A and CRP as inflammatory markers in infectious diseases. Clin Chem 1993; 39, 2:293-297.
9. Kushner I, Ganapath MK, Mac.lntyre. Regulation of biosyntesis and secretion of human CRP and SAA. In acute phase proteins in the acute phase response. Pepys Springer-Verlag, Londan: 1989; 69-83.
10. Ramadori G, Sipe SD, Colten HR. Expression and regulation of the murine SAA gen in extrahepatik sites. J Immunol 1985; 135: 3645-3647.
11. Abul K. Abbas, Lichtman AH, Pober TS. Cellular and molecular immunology. 1991; Philadelphia: Saunders Company, 226-242.
12. Arai K, Miyojima A, Miyatakes S, Yokota T. Cytokines: coordinators of immune and inflammatory responses. Ann Rev Biochem 1990; 59: 783-836.
13. Benson MD, Scheinberg MA, Shiroma T. Kinetics of serum amyloid protein A in case in induced murine amyloidosis. J Clin Invest 1977; 59: 412-416.
14. Dovvton B, Peters CN, Jestus JJ. Regulation of SAA gen expression in Syrian hamsters my cytokines. Inflammation 1991; 15, 5: 391-397.
15. Brissette L, Young I, Narindra SS. Differential induction of SAA gen family in response to an inflammatory agent and amyloid enhancing factor. J Biol Chem 1989; 264, 32: 19327-19323.
16. Beutler B, Cerami A. The biology of cachectin - TNF a. A primary mediator of the host response. Ann Rev Immunol 1988; 7: 625-655.
17. Andes T, Geiger T, Hirano T. Action of rh IL-6, IL-1 b and TNFa on mRNA induction of acute phase proteins. Eur J Immunol 1988; 18: 739-746.
18. Cohen AS, Shirahama JD. Amyloid proteins, precursors, mediator, enhancer. Lab Invest 1983; 48: 1-6.
19. Meyerhoff J. FMF. Medicine 1980; 59: 66-70
20. Blum A, Grafni J, Sohor E, Shibolets S. Amyloidosis as the sole manifestation of FMF. Ann Intern Med 1972; 57: 795.
21. Ramadori G, Sıpe JD, Dinarello CA. Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant IL-1 and purified human IL-1. J Exp Med 1985; 162:930-942.
22. Marinkoviç S, Jahreis GP, Wang. GG, Bavmann H. IL-6 modulates the synthesis of a spesific set of acute phase plasma proteins in vivo. J Immunol 1989; 142, 3: 808-812.
23. VVoo P,Sipe J, Dinarello C, Colten Hr. Structure of a human serum amyloid A gen and modulation of its expression in transfected L celi. J Biol Chem 1987; 262, 32: 15790-15795.
24. Ramadori G, Damme JV, Rieder KH. IL-6, the third mediater of acute phase reaction, modulates hepatic protein synthesis in human and mouse. Comparison vvith IL-1 and TNF. Eur J Immunol 1988; 18: 1259-1264.
25. Schindler R, Moncilla J, Endres S ve ark. Correlations and interactions in the production of IL-6, IL-1 and TNF in human blood mononuclear celis. IL-6 supresses IL-1 and TNF. Blood 1990; 75, 1: 40-47.
26. Alan S, Cohen AS, Martha MD. New frontiers in the study of amyloidosis. N Engl J Medicine 1990; Aug. 23: 542-543.
27. Castel JV, Gomoz Lechon MD, Davic M ve ark. Recombinant human IL-6 regulates the synthesis of acute phase pıoteins in human hepatocytes. 1988; FEBS Lett, 232: 347-350
28. Nijsten MW, Groot ER, Ten Duis HJ. Serum levels of IL-6 and acute phase responses. Lancet 1987; Oct. 17: 921 -922.
29. Darlington GJ, Wilson DR, Lachman LB. Monocyte-conditioned medium, IL-1 and TNF stimulate the acute phase response in human hepatoma cells in vitro. J Celi Biol 1986; 103: 787-793.
30. Kurdovvska A, Magielska-Zero D, Rokita H ve ark. Limited effects of recombinant human and murine IL-I and TNF on production of acute phase proteins by cultured rat hepatocytes. Biochem Int 1987; 14, 3: 553-560.
31. Schultz PJ, Arnold D. Properties of four acute phase proteins: CRP, SAA, a, glycoprotein and fibrinogen. Sem Arth Rheum 1990; Dec. 20, 3: 129-147.
32. Husebek A, Skogen B, Husby G ve ark. Transformation of amyloid precursor SAA to protein AA and incorporation in amyloid fibrils in vivo. Scand. J Immunol 1985; 21: 283-287.