Phospholipid fatty acid composition of rat, rabbit, human and dog plasma

Çalışmanın amacı rat, tavşan, insan ve köpek gibi farklı türlerde plazma fosfolipidlerinin yağ asitlerini tayin etmek ve kıyaslamaktır. Türlerin fosfolipid yağ asitleri başlıca C16:0, C18:0, C118:1, C18:2, C20:4 dir. Fosfolipid yağ asidi birkaç istisna dışında genellikle şu şekilde azalmaktadır: SFA (doymuş yağ asidi) > MUFA (tekli doymamış yağ asidi) > PUFA (çoklu doymamış yağ asidi). PUFA PE (fosfatidil etanolamin) ve PC (fosfatidil kolin) de yüksek düzeydedir ve tavşan ve insan plazmasında PUFA yüzdesi MUFA'ya göre fazladır. Öte yandan PUFA köpekte PC ve PS (fosfatidil serin) de ratda ise PI (fosfatidil inozitol), PC ve SPH (sfingomiyelin) de yüksek bulunmuştur. C18:1 diğer MUFA ye kıyasla fazlaydı. PUFA içinde C18:2 tavşanda diğer türlerle kıyaslandığında yüksek ve C20:4 ise düşüktü. C18:2 major PUFA olup C20:4 bunu takip etti. Bu yağ asitleri bütün türlerde başlıca PC ve PE de ve müteakiben PS, PI ve SPH de konsantre olmuştu. Diğer PUFA (C20:2, C18:3, C20:3, and C20:5) köpekte %0.1 den azdı ve ratda da çok küçük miktarlardaydı. Bu PUFA tavşanda PE ve PC'de aynı zamanda insanlarda diğer fosfolipidlerde bulundu. Köpekde LCPUFA (uzun zincirli çoklu doymamış yağ asitleri) yoktu ve rat PC de C22:6 çok azdı.

Sıçan, tavşan, insan ve köpek plazma fosfolipidlerinin yağ asidi kompozisyonu

The purpose of this study was to investigate and compare the fatty acids of plasma phospholipids in rat, rabbit, human and dog. The prominent fatty acids of phospholipids in the species were C16:0, C18:0, C118:1, C18:2, C20:4. Fatty acids generally decreased in the following order: SFA (Saturated fatty acids) > MUFA (monosaturated fatty acid) > PUFA (polyunsaturated fatty acid) with little exceptions. PUFA was higher in PE (phosphatidyl ethanolamine) and PC (phosphatidyl choline) and PUFA > MUFA in rabbit and human plasma, whereas PUFA was higher in PC and PS in dog and in PI, PC and SPH in rat. C18:1 was higher than the other MUFA. Among PUFA C18:2 was higher and arachidonate (C20:4) was lower in rabbit compared to other species. C18:2 was major PUFA and C20:4 was the second one mainly in PC and PE and followed by PS (phosphatidyl serine), PI (phosphatidyl inositol) and SPH (sphingomyelin) in all of the species. Others (C20:2, C18:3, C20:3, and C20:5) were less than %0.1 in dog and also present in very small amounts in rat. These PUFA were present in PE and PC in rabbit and as well as in the other phospholipids in human. LCPUFAs (long chain polyunsaturated fatty acids) were not present in dog and rat had small amounts of C22:4 in PC.

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