NEOPTERİN: GASTROİNTESTİNAL KANSERDE OLASI BİR BİYOBELİRTEÇ

Amaç: Dünyadaki başlıca ölüm nedenlerinden biri olan kanser, hiperproliferatif bir bozukluk olarak tanımlanmaktadır. Bozulmuş doku homeostazına karşı doğal bir immün yanıt olan inflamasyon, kanserin önemli bir özelliği haline gelmiştir. Neopterin, proinflamatuvar sitokinlerin uyarımı ile aktive olan makrofajlar tarafından üretilmektedir. Neopterin, kanser dahil immün aktivasyon ile ilişkili farklı bozukluklarda artanimmün aktivasyon biyobelirtecidir. Çalışmamızda gastrointestinal kanserlerde neopterin düzeylerini tayin etmeyi ve alt gruplar arasındaki farklılıkları değerlendirmeyi amaçladık.Gereç ve Yöntem: Bu çalışmaya 108 gastrointestinal kanserli hasta ve 25 sağlıklı kontrol dahil edildi. Hastalar üç alt gruba ayrıldı. Birinci grup mide kanserli 40 kişi, ikinci grup kolorektal kanserli 40 kişi ve üçüncü grup pankreas, karaciğer ya da özofagus kanserli 28 kişiden oluştu. Serum neopterin düzeyleri ELISA ile ölçüldü.Sonuç ve Tartışma: Neopterin, kontrollerle karşılaştırıldığında tüm hasta gruplarında anlamlı olarak daha yüksekti (p<0.05). Tüm hasta gruplarında HDL-kolesterol, albümin ve total protein düzeyleri kontrol grubuna göre anlamlı derecede düşük bulundu. Sonuçlarımız neopterin düzeylerinin, gastrointestinal kanserlerde arttığını göstermektedir. Dolayısıyla, neopterin, gastrointestinal kanserli hastalarda potansiyel tahmini bir belirteç olabilir.

NEOPTERIN: A POSSIBLE BIOMARKER IN GASTROINTESTINAL CANCER

Objective: Cancer, one of the major causes of death in the world, is described as a hyperproliferative disorder. Inflammation which is a primary innate immune response to perturbed tissue homeostasis, has become an important hallmark of cancer. Neopterin is produced by activated macrophages upon stimulation with proinflammatory cytokines. It is immune activation biomarker increased in different disorders associated with immune activation, including cancer. We aimed to determine the neopterin levels in gastrointestinal cancers (GIC) and to evaluate the differences among the subgroups.

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