Dorukhan HIŞIR, Meliha EKİNCİ, Derya İLEM-ÖZDEMİR

HEDEFE YÖNELİK TEDAVİDE GÜNCEL YAKLAŞIMLAR: LUTESYUM-177 İLE İŞARETLİ RADYOFARMASÖTİKLER

Amaç: Son yıllarda, hedefe yönelik radyonüklid tedavisindeki ilerlemeler sayesinde hastalıkların erken teşhis ve tedavisinde önemli gelişmeler kaydedilmiştir. Tanı ve tedavi yöntemlerini birleştiren “teranostik” kavramının doğmasıyla Lutesyum-177 (Lu-177), hedefe yönelik tedavide önemli bir yer edinmiş ve bu alanda öncü bir bileşik haline gelmiştir. Bu derlemede, radyofarmasötikler, hedefe yönelik tedavi, teranostikler ve Lu-177 ile ilgili temel bilgilerin anlatılması, 177Lu ile işaretli moleküler taşıyıcılar ile 177Lu’dan hareketle hazırlanan radyofarmasötiklerin sunulması ve bu konularda yapılmış olan çalışmaların gözden geçirilmesi amaçlanmıştır.

Anahtar Kelimeler:

Lutesyum-177, radyonüklid, radyofarmasötik, teranostik

CURRENT APPROACHES TO TARGETED THERAPY: LUTETIUM-177 LABELED RADIOPHARMACEUTICALS

Objective: In recent years, thanks to advances in targeted radionuclide therapy, significant advances have been made in the early diagnosis and treatment of diseases. With the emergence of the concept of "theranostic", which combines diagnosis and treatment methods, Lutetium-177 (Lu-177) has gained an important place in targeted therapy and has become a leading compound in this field. In this review, it is aimed to explain the basic information about radiopharmaceuticals, targeted therapy, theranostics and Lu-177, to present 177Lu-labeled molecular carriers and 177Lu-labeled radiopharmaceuticals and to review the studies on these subjects.

Keywords:

Lutetium-177, radionuclide, radiopharmaceutical, theranostic,

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