Oya TOPALOĞLU, Hüsniye BAŞER, Bekir ÇAKIR, Ayşegül AKSOY ALTINBOĞA, Reyhan ERSOY, Serap ULUSOY

Diferansiye Tiroid Kanserlerinin Klinikopatolojik Özelliklerinin Değerlendirilmesi

Amaç: Diferansiye tiroid kanserinin (DTK) büyük çoğunluğunu papiller tiroid kanserleri (PTK) vefolliküler tiroid kanserleri (FTK) oluşturmaktadır. PTK varyantlarından olan folliküler varyant‐ PTK (FVPTK)sıklığı son yıllarda artmaktadır. Ancak bu alt grup için klinikopatolojik, radyolojik ve sitolojiközelliklere ait literatür bilgisi kısıtlıdır. Bu çalışmada amaç, merkezimizde takip edilen FTK ve FV‐PTKtanısı alan hastaların klinikopatolojik özelliklerin karşılaştırılması, preoperatif radyolojik ve sitolojiközellikler ile histopatolojik tümöral özellikler açısından bu iki grup arasında fark olup olmadığınınaraştırılmasıdır.Materyal ve Metot: Bu retrospektif çalışmaya toplam 177 (144 FV‐PTK ve 30 FTK) hasta dahil edildi.Her iki hasta grubunun preoperatif tiroid fonksiyon testleri, tiroid antikorları, nodüllerininultrasonografik ve sitolojik özellikleri, operasyon sonrası histopatolojik özellikleri karşılaştırıldı.Bulgular: FV‐PTK grubunda 23 (%16) erkek hasta, 121 (%84) kadın hasta var iken, FTK grubunda 11(%36,70) erkek 19 (%63,30) kadın hasta mevcut olup erkek hastaların sayısı FTK grubunda istatistikselolarak anlamlı derece fazla idi (p=0,009). Preoperatif ultrasonografik özellikler karşılaştırıldığında FTKgrubundaki nodüllerin longitudinal çapı ve volümü FV‐PTK grubundan istatistiksel olarak anlamlıderecede daha büyüktü (sırası ile p=0,007 ve p=0,005). Ultrasonografik diğer özelliklerden açısındanistatistiksel anlamlı farklılık izlenmedi. Her iki gruptaki nodüllerin preoperatif sitoloji sonuçlarıBethesda sınıflamasına göre karşılaştırıldığında folliküler neoplazi/folliküler neoplazi şüphesi (FN/FNŞ)sitoloji sonucu FTK grubunda istatistiksel olarak anlamlı derece daha fazlaydı (%15,80’e karşılık %5,30,p=0,017). Histopatolojideki tümöral özellikle değerlendirildiğinde FTK grubunda tümör çapı, FV‐PTKgrubundan istatistiksel olarak anlamlı derece daha büyüktü (median tümör çapı 25 mm’e karşılık 14,5mm, p

The Evaluation of Clinicopathologic Features of Differentiated Thyroid Cancers

Objectives: Papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC) constitute most of the differentiated thyroid cancers (DTC). Frequency of follicular variant (FV)PTC, a variant of PTC, has been increasing in recent years. However, the data concerning clinicopathologic, radiologic, and cytologic features of this subtype are limited in the literature. The aim of this study was to compare the clinicopathologic features of patients who were diagnosed and followed‐up as FTC and FV‐PTC in our institution, and also to investigate if there are differences between two groups in the preoperative radiologic, cytologic characteristics, and histopathologic tumoral features. Materials and Methods: Totally 177 (144 FV‐PTC and 30 FTC) patients were included in this retrospective study. Preoperative thyroid function tests, thyroid antibodies, ultrasonographic and cytologic features of nodules, postoperative histopathologic features of both groups were compared. Results: FV‐PTC group had 23 (16%) male and 121 (84%) female patients, FTC group had 11 (36.70%) male and 19 (63.30%) female patients. FTC group had significantly higher male patients (p=0.009). When preoperative ultrasonographic features were compared, we found that longitudinal diameters and volume of nodules were significantly higher in the FTC group (respectively, p=0.007 and p=0.005). There were no significant differences according to other ultrasonographic features. In comparison to preoperative nodular cytological results according to the Bethesda classification, follicular neoplasia/suspicious for follicular neoplasia (FN/SFN) cytology was found higher in FTC group compared to FV‐PTC (15.80% vs 5.30%, p=0.017). In the evaluation of histopathological tumoral features, tumor diameter was detected higher in the FTC group (median tumor diameter; 25 mm vs 14.5 mm, p

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