Halil İbrahim ERDOĞDU, Eray ATALAY, Edip KAPI, Gül GÜRSOY, Kaan TUR, Pınar ŞİŞMAN

TÜRKİYE’NİN DOĞU BÖLGESİNDE 25-HİDROKSİ VİTAMİN D SEVİYESİ, DİSLİPİDEMİ VE İNSÜLİN REZİSTANSI ARASINDAKİ İLİŞKİ

AMAÇ: D vitamini eksikliği ve yetersizliğinin birçok kronik hastalık ile ilişkili olduğu kabul edilmektedir. D vitamini, dislipidemi ve insülin direnci arasındaki ilişki, ilgili hastalıkların erken teşhisi ve tedavisini sağlayabileceğinden, bu çalışmada D vitamini düzeyleri ile dislipidemi ve insülin direnci arasındaki ilişkiyi araştırmayı amaçladık. GEREÇ VE YÖNTEMLER: Çalışma 249 sağlıklı kişi ile gerçekleştirilmiştir. Vitamin D dahil olmak üzere laboratuvar testleri yapıldı. İnsülin direnci, homeostaz model değerlendirme-insülin direnci indeksi ile hesaplandı. Ayrıca çeşitli vitamin D düzeyleri ile yaş, cinsiyet, glikoz ve lipit parametreleri ile insülin direnci arasındaki ilişkiyi araştırdık. BULGULAR: Katılımcıların D vitamini düzeyi erkeklerde kadınlara göre daha yüksekti. Vitamin D seviyeleri yaş arttıkça azaldı. Katılımcıların %3,6'sında normal D vitamini düzeyleri, %14,5'inde yetersizlik, %45'ında eksiklik, %36,9'unda ciddi eksiklik saptandı. İnsülin direnci, ciddi yetersizliği olanların %57,6'sında, yetersizliği olanların %22,3'ünde ve eksikliği olanların %8,3'ünde saptandı. Normal D vitamini seviyeleri olanların hiçbiri insülin direncine sahip değildir. D vitamini grupları arasında lipid parametresi değerleri açısından anlamlı fark bulunmadı. D vitamini azaldıkça açlık kan şekeri ve insülin değerleri arttı. SONUÇ: D vitamini ve dislipidemi düzeyleri arasında bir ilişki olmamasına rağmen, D vitamini ve insülin direncinin birbirinden bağımsız olarak değerlendirilemeyeceğini düşündük. D vitamini taraması ile eksik olduğu tespit edilenler için erken müdahaleler, metabolik sendrom ve diyabet gibi diğer hastalıklarla ilgilenirken yardımcı olabilir.

THE RELATIONSHIP BETWEEN 25-OH VITAMIN D LEVEL, DYSLIPIDEMIA AND INSULIN RESISTANCE IN EASTERN PART OF TURKEY

BACKGROUND: It has been accepted that vitamin D deficiencyand insufficiency are associated with many chronic diseases. As therelationship between vitamin D, dyslipidemia and insulin resistancemay provide early diagnosis and treatment of related diseases, inthis study, it was aimed to investigate the relationship betweenvitamin D levels and dyslipidemia and insulin resistance.METHODS: The study was conducted with 249 healthy volunteersin Kafkas University Departement of Internal Medicine. Laboratoryexaminations including Vitamin D were conducted. Insulinresistance was calculated by homeostasis model assessment-insulinresistance index. We also searched the relationship between variousVitamin D levels and age, gender, glucose and lipid parameters andinsulin resistance.RESULTS: Vitamin D level of the participants was higher in malesthan females. Vitamin D levels decreased as age increased. It wasfound that 3.6% of the participants had normal vitamin D levels,14.5% had insufficiency, 45% had deficiency and 36.9 % had severedeficiency. Insulin resistance was detected in 57.6% of those withsevere deficiency, 22.3% of those with deficiency, and 8.3% of thosewith insufficiency. None of those with normal Vitamin D levelshave insulin resistance. No significant difference was found betweenvitamin D groups in terms of lipid parameter values. As Vitamin Ddecreased, fasting blood glucose and insulin values increased.Conclusion: We concluded that although there was not a relationshipbetween vitamin D and dyslipidemia levels, we thought that vitaminD and insulin resistance can not be considered independent of eachother. Early interventions for those who are found to be deficient byvitamin D scans may also help dealing with other diseases such asmetabolic syndrome and diabetes.

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