Eray ATALAY, Bilge Kağan TUR, Gülizar KUTAS KURT, Gül GÜRSOY

Tiroid Nodullerinde Ultrasonografik ve Sitolojik bulgular ile Vitamin D Arasındaki İlişkinin Değerlendirilmesi

Amaç: Vitamin D ile bazı kanserler arasında bir ilişki olduğu bildirilmiş, ancak vitamin D ile tiroid kanserleri arasındaki ilişki tam olarak değerlendirilmemiştir. Bu çalışmanın amacı, D vitamini düzeyleri ile tiroid nodüllerinin ultrasonografik, sitolojik ve postoperatif patolojik verileri arasındaki ilişkiyi değerlendirmektir. Yöntem: Çalışmamıza tiroid nodül varlığı nedeniyle tiroid ince iğne aspirasyon biyopsisi (TİİAB) sonrası tiroidektomi operasyonu uygulanan 225 hasta dahil edildi. Çalışmaya dahil edilen hastaların preoperatif ultrasonografik bulguları, TİİAB ve tiroidektomi operasyonu sonrası elde edilen sitopatolojik sonuçları ile serum vitamin D düzeyleri kaydedildi. Vitamin D düzeyleri ile tiroid nodüllerinin ultrasonografik ve sitolojik bulguları arasındaki ilişki analiz edildi. Sonuçlar: Vitamin D ile tiroid nodüllerinin ultrasonografik özellikleri, TİİAB ve cerrahi sonrası histopatolojik sonuçları arasında istatistiksel anlamlı ilişki saptanmadı. Tartışma: Sonuçlarımız D vitamini ile tiroid nodüllerinin ultrasonografik özellikleri, TİİAB ve cerrahi sonuçları arasında ilişki olmadığını göstermiştir. Bununla birlikte, sonuçlarımızı geriye dönük olarak incelediğimizde, operasyon sonrası malign saptanan çok az sayıda vakanın preoperatif TİİAB değerlendirmesinde benign saptandığını gözlemledik. Bu olgular vitamin D düzeyleri düşük ve nodül boyutu 2.5 cm'nin üzerinde olan olgulardı. Vitamin D eksikliğinin eşlik ettiği büyük tiroid nodülleri ile malignite arasındaki ilişkiyi değerlendirmek için daha kapsamlı çalışmalara ihtiyaç olduğunu düşünüyoruz.

Anahtar Kelimeler:

Vitamin D, Tiroid Nodulü, Ultrasonografi, Sitoloji

The Relationship Between Vitamin D and Ultrasonographic and Cytological Findings of Thyroid Nodules

Objective: There are reported associations between Vitamin D and some cancers, but the relationship between vitamin D and thyroid cancers has not been fully evaluated. The aim of this study was to evaluate the relationship between vitamin D levels and ultrasonographical, cytological and postoperative pathological data of the thyroid nodules.Methods: The study included 225 patients who underwent thyroidectomy after thyroid fine needle aspiration biopsy (FNAB) due to the presence of thyroid nodules.The preoperative ultrasonographical findings, the cytopathological results obtained after FNAB and thyroidectomy operation and serum vitamin D levels were recorded. The relationship between vitamin D levels and ultrasonographical and cytological findings of thyroid nodules was analyzed.Results: There was no statistically significant relationship between vitamin D and ultrasonographical and histopathological results of thyroid nodules. Conclusions: Our results showed that there were no relationship between Vitamin D and ultrasonographical characteristics, biopsy and surgery results of thyroid nodules. However, when we retrospectively examined our results, we observed that very few cases with malignancy were found to be benign in the preoperative FNAB evaluation. These patients had low vitamin D levels and a nodule size of more than 2.5 cm. We think that more extensive studies are needed to assess the association between malignancy and large thyroid nodules associated with vitamin D deficiencies.

Keywords:

Vitamin D, Thyroid Nodules, Ultrasonography, Cytology,

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