Aykut BAŞER, Cemil AYDIN, Bilal ÇELİKÖRS, Hülya YILMAZ BAŞER, Mehmet Murat BAYKAM, Okan ALKIŞ

PSA seviyesi 4-10 ng/mL olan hastalarda alt üriner sistem semptomları patoloji sonucunu ön görebilir mi?

Amaç: Bu çalışmada PSA seviyesi 4-10 ng/mL olan hastalarda alt üriner sistem semptomalarının prostat adenokanser ve benign prostat hiperplazisini ön görecek bir parametre olup olmadığını araştırmayı amaçladık. Gereç ve Yöntemler: 01 Haziran 2019 - 01 Şubat 2020 tarihleri arasında PSA değeri 4-10 ng/ml olan ilk kez TRUS-Bx uygulanan 75 hasta prospektif olarak çalışmaya dahil edildi. Hastaların yaş, BMI, PSA, Prostat hacmi, PSA dansitesi, uluslararası prostat semptom skorları ve uluslararası erektil fonksiyon skorları kayıt edildi. Patoloji sonucuna göre grup 1 (benign prostat hiperplazisi) ve grup 2 (prostat adenokanser) olarak hastalar 2 gruba ayrılarak belirtilen parametreler ile ilişkisi araştırıldı. Bulgular: PSA değeri 4-10 ng/ml olan ilk kez TRUS-Bx uygulanan 75 hastanın patoloji sonucunda; 57 (%76) hastada Benign Prostat Hiperplazisi (BPH) (grup 1), 18 (%24) hastada Prostat Adenokanser (PCa) (grup 2) saptandı. İncelenen parametrelerden sadece rektal tuşe de sertlik bulgusu (p=0.001) ve IPSS skor düşüklüğü (p=0.022) Grup 2’de grup 1’e göre istatistiksel anlamlı farklılık saptandı. Yapılan korelasyon analizinde de bulgular teyit edildi. Sonuç: PSA 4-10 ng/mL olan hastalar için IPSS skor düşüklüğü, rektal tuşe de sertlik olması kanser saptanma ihtimalini arttırmaktadır.

Anahtar Kelimeler:

Prostat biyopsisi, Alt üriner sistem semptomları, Prostat kanseri, IPSS, BPH

Can lower urinary tract symptoms predict pathology outcome in patients with a PSA level of 4-10 ng/mL?

Objective: In this study, we aimed to investigate whether lower urinary tract symptoms are a parameter to predict prostate adenocarcinoma and bening prostatic hyperplasia in patients with a PSA level of 4-10 ng / mL. Material and Methods: 75 patients who were administered TRUS-Bx for the first time with a PSA value of 4-10 ng / ml between 01 June 2019 and 01 February 2020 were included prospectively. Age, BMI, PSA, Prostate volume, PSA density, international prostate symptom scores and international erectile function scores of the patients were recorded. According to the pathology results, patients as group 1 (bening prostatic hyperplasia) and group 2 (prostate adenocarcinoma) were divided into two groups and their relationship with the specified parameters was investigated. Results: As a result of the pathology of 75 patients who had TRUS-Bx for the first time with a PSA value of 4-10 ng / ml; Bening Prostate Hyperplasia (BPH) (group 1) was detected in 57 (76%) patients, and Prostate Adenocarcinoma (PCa) (group 2) in 18 (24%) patients. Among the parameters examined, only the stiffness in digital rectal examination finding and IPSS score low were statistically significant in Group 2 compared to group 1. In the correlation analysis, the findings were confirmed. Result: For patients with PSA 4-10 ng / mL, low IPSS score and rectal touch stiffness increase the chance of cancer detection.

Keywords:

Prostate biopsy, Lower urinary system symptoms, Prostate cancer, IPSS, BPH,

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