Selma ÖZBEK UZMAN, Gülizar DEMİROK, Züleyha YALNIZ AKKAYA, Ümit EKŞİOĞLU, Evin ÖZDEMİR, Mehmet YAKIN, Firdevs ÖRNEK, Ayşe BURCU

MAKÜLER KORNEA DİSTROFİSİNDE KORNEANIN BİYOMEKANİK ÖZELLİKLERİ

AMAÇ: Maküler kornea distrofisinin (MKD) korneanın biyomekanik özellikleri üzerindeki etkisinin değerlendirilmesi ve sağlıklı bireyler ile karşılaştırılması amaçlandı. GEREÇ VE YÖNTEM: Klinik olarak MKD tanısı konulmuş 45 hastanın 45 gözü (MKD grubu) ve 61 sağlıklı bireyin 61 gözü (kontrol grubu) çalışma kapsamına alındı. Tam oftalmolojik muayene sonrasında oküler cevap analizörü (ORA) ile, kornea histerezisi (KH), kornea direnç faktörü (KRF), Goldmann ile uyumlu göz içi basıncı (GİBg) ve kornea düzeltmeli GİB (GİBcc) değerleri ve Pentacam veya ultrason pakimetrisi ile merkezi kornea kalınlığı (MKK) ölçüldü ve kaydedildi. BULGULAR: İki grup, ortalama yaş (37,49 ± 10,05 ve 36,70 ± 10,72 yıl, p=0,703) ve cinsiyet dağılımı açısından (p=0,976) benzerdi. Maküler kornea distrofisi grubu ve kontrol grubunda ortalama KH [9,52 ± 1,37 ve 10,99 ± 1,16 mmHg (p

BIOMECHANICAL PROPERTIES OF THE CORNEA IN MACULAR CORNEAL DYSTROPHY

AIM: To evaluate the effect of macular corneal dystrophy (MCD) on the corneal biomechanical properties and to compare it with healthy individuals. MATERIAL AND METHOD: 45 eyes of 45 patients with a clinical diagnosis of MCD (MCD group) and 61 eyes of 61 healthy individuals (control group) were included in the study. After the full ophthalmologic examination, corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg) and corneal-compensated IOP (IOPcc) and central corneal thickness (CCT) were measured and recorded. RESULTS: The two groups were similar in terms of mean age (37.49 ± 10.05 and 36.70 ± 10.72 years, p = 0.703) and gender distribution (p = 0.976). In the MCD group and control group mean CH [9.52 ± 1.37 and 10.99 ± 1.16 mmHg (p

PDF

___

1.)Javadi MA, Rafee’i AB, Kamalian N, et al. Concomitant keratoconus and macular corneal dystrophy. Cornea. 2004;23:508-12.
2.)Kocluk Y, Yalniz-Akkaya Z, Burcu A, et al. Corneal topography analysis of stromal corneal dystrophies. Pak J Med Sci. 2015;31:116-120.
3.)Lang GK, Naumann GO. The frequency of corneal dystrophies requiring keratoplasty in Europe and the U.S.A. Cornea. 1987;6:209-11.
4.)Alzuhairy S, Alkatan HM, Al-Rajhi AA. Prevalence and histopathological characteristics of corneal stromal dystrophies in Saudi Arabia. Middle East Afr J Ophthalmol. 2015;22:179-85.
5.)Pandrowala H, Bansal A, Vemuganti GK, et al. Frequency, distribution, and outcome of keratoplasty for corneal dystrophies at a tertiary eye care center in South India. Cornea. 2004;23:541-6.
6.)Garcia-Porta N, Fernandes P, Queiros A, et al. Corneal biomechanical properties in different ocular conditions and new measurement techniques. ISRN Ophthalmol. 2014;4:724546.
7.)Gkika M, Labiris G, Giarmoukakis A, et al. Evaluation of corneal hysteresis and corneal resistance factor after corneal cross-linking for keratoconus. Graefes Arch Clin Exp Ophthalmol. 2012;250:565-73.
8.)del Buey MA, Cristóbal JA, Ascaso FJ, et al. Biomechanical properties of the cornea in Fuchs’ corneal dystrophy. Invest Ophthalmol Vis Sci. 2009;50:3199-3202.
9.)Clemmensen K, Hjortdal J. Intraocular pressure and corneal biomechanics in Fuchs’ endothelial dystrophy and after posterior lamellar keratoplasty. Acta Ophthalmologica. 2014;4:350-54.
10.)Ortiz D, Piñero D, Shabayek MH, et al. Corneal biomechanical properties in normal, post-laser in situ keratomileusis, and keratoconic eyes. J Cataract Refract Surg. 2007;33:1371-5.
11.)Weiss JS, Moller HU, Aldave AJ, et al. IC3D classification of corneal dystrophies-edition 2. Cornea. 2015;34:117-59.
12.)Moshirfar M, Edmonds JN, Behunin NL, et al. Corneal biomechanics in iatrogenic ectasia and keratoconus: A review of the literature. Oman J Ophthalmol. 2013;6:12-7.
13.)Del Monte DW, Kim T. Anatomy and physiology of the cornea. J Cataract Refract Surg. 2011;37:588-598.
14.)Ihanamaki T, Pelliniemi LJ, Vuorio E. Collagens and collagen- related matrix components in the human and mouse eye. Prog Retin Eye Res. 2004;23:403-44.
15.)Murab S, Chameettachal S, Ghosh S. Establishment of an in vitro monolayer model of macular corneal dystrophy. Lab Invest. 2016;96:1311-26.
16.)Akhtar S, Alkatan HM, Kirat O, et al. Collagen fibrils and proteoglycans of macular dystrophy cornea: ultrastructure and 3D transmission electron tomography. Microsc Microanal. 2015;21:666-79.
17.)Meek KM, Quantock AJ, Elliott GF, et al. Macular corneal dystrophy: the macromolecular structure of the stroma observed using electron microscopy and synchrotron X-ray diffraction. Exp Eye Res. 1989;49:941-958.
18.)Quantock AJ, Meek KM, Thonar EJ, et al. Synchrotron X-ray diffraction in atypical macular dystrophy. Eye (Lond). 1993;7:779-784.
19.)Birk DE, Fitch JM, Babiarz JP, et al. Collagen fibrillogenesis in vitro: interaction of types I and V collagen regulates fibril diameter. J Cell Sci. 1990;95:649-657.
20.)Shah S, Laiquzzaman M, Bhojwani R, et al. Assessment of the biomechanical properties of the cornea with the ocular response analyzer in normal and keratoconic eyes. Invest Ophthalmol Vis Sci. 2007;48:3026-3031.
21.)Kara N, Altinkaynak H, Baz O, et al. Biomechanical evaluation of cornea in topographically normal relatives of patients with keratoconus. Cornea. 2013;32:262-266.
22.)Meek KM, Tuft SJ, Huang Y, et al. Changes in collagen orientation and distribution in keratoconus corneas. Invest Ophthalmol Vis Sci. 2005;46:1948-1956.
23.)Wollensak G, Spoerl E, Seiler T. Stress-strain measurements of human and porcine corneas after riboflavinultraviolet-A-induced cross-linking. J Cataract and Refract Surg. 2003;29:1780-1785.
24.)Poli M, Cornut PL, Balmitgere T, et al. Prospective study of corneal collagen cross-linking efficacy and tolerance in the treatment of keratoconus and Corneal ectasia: 3-year results. Cornea. 2013;5:583-590.
25.)Kamiya K, Shimizu K, Ohmoto F. The changes in corneal biomechanical parameters after phototherapeutic keratectomy in eyes with granular corneal dystrophy. Eye (Lond). 2009;23:1790-1795.
26.)Medeiros FA, Weinreb RN. Evaluation of the influence of corneal biomechanical properties on intraocular pressure measurements using the ocular response analyzer. J Glaucoma. 2006;15:364-370.
27.)Touboul D, Roberts C, Kérautret J, et al. Correlations between corneal hysteresis, intraocular pressure, and corneal central pachymetry. J Cataract Refract Surg. 2008;34:616-622.28.
28.)Franco S and Lira M. Biomechanical properties of the cornea measured by the Ocular Response Analyzer and their association with intraocular pressure and the central corneal curvature. Clin Expt Optom. 2009;92:469-475.