HEMATOLOJİK PARAMETRELER, BEHÇET HASTALIĞININ DEĞERLENDİRİLMESİNDE KULLANIŞLI MIDIR ?

Gİrİş: Behçet hastalığı (BH) otoinflamatuar bir hastalıktır. Hematolojik parametreler birçok hastalıkta inflamasyon belirteci olarak araştırılmıştır. Bu çalışmanın amacı, Behçet hastalarında hemogram parametrelerini (nötrofil-lenfosit oranı, platelet-lenfosit oranı, ortalama trombosit hacmi, kırmızı kan hücresi dağılım genişliği ve trombosit dağılım genişliği) hastalık aktivitesinin bir belirteci olarak değerlendirmek ve farklı klinik bulgular ile ilişkisini tespit etmektir. Materyal ve metod: Bu tek merkezli, kesitsel çalışmaya 141 (80 erkek, 61 kadın) Behçet hastası ve 96 (51 erkek, 45 kadın) sağlıklı kontrol grubu dahil edildi. Behçet hastası ve sağlıklı kontrol gruplarında C-reaktif protein (CRP) ve eritrosit sedimentasyon hızı (ESR) dahil olmak üzere hematolojik ve inflamatuar parametreler incelendi. Behçet hastalarındaki hastalık aktivitesi, Behçet Hastalığı Anlık Aktivite Formu (BDCAF) kullanılarak değerlendirildi. Bulgular: Nötrofil-lenfosit oranı ve kırmızı kan hücresi dağılım genişliği değerleri BH grubunda sağlıklı kontrol gruplarına göre istatistiksel olarak daha yüksek bulundu. Ortalama trombosit hacmi düzeyleri BH grubunda sağlıklı kontrol gruplarına göre düşüktü. Bakılan hemogram parametreleri aktif ve inaktif hastalıkta benzerdi. Major organ tutulumu olan Behçet hastalarında Nötrofillenfosit oranı ve trombosit dağılım genişliği mukokutanöz gruba kıyasla istatistiksel olarak daha yüksek bulundu. Sonuçlar: Bu çalışma, inflamatuar göstergelerin Behçet hastalarında hastalık aktivitesi hakkında yeterli bilgi sağlayamayacağını göstermiştir. Nötrofil-lenfosit oranı ve trombosit dağılım genişliğinin ikisi de BH'da major organ tutulumu ile iyi ilişki göstermiştir. Nötrofillenfosit oranı üveiti olanlarda, ortalama trombosit hacmi eritema nodozumu olanlarda ve trombosit dağılım genişliği nörobehçet ve oral ülseri olan hastaları takip etmek için kullanılabilir.

ARE HEMATOLOGICAL PARAMETERS USEFUL IN THE EVALUATION OF BEHÇET’S DISEASE ?

Purpose: Behçet's disease (BD) is an autoinflammatory disease.Hematological indices have been investigated in many diseases asa marker of inflammation. The aim of this study was to evaluatehemogram parameters [neutrophil–lymphocyte ratio (NLR),platelet–lymphocyte ratio (PLR), mean platelet volume (MPV),red blood cell distribution width (RDW), and platelet distributionwidth (PDW)] in patients with BD as a marker of disease activityand to determine associations with different clinical manifestations.Material and Methods: This single-centre, cross-sectionalstudy included 141 (80 male, 61 female) Behçet’s disease (BD)patients and 96 (51 male, 45 female) healthy subjects. Hematologicaland inflammatory parameters including C-reactive protein (CRP),and erythrocyte sedimentation rate (ESR) were examined in theBD and healthy control groups. Disease activity in the BD patientswas assessed using the Behçet’s Disease Current Activity Form(BDCAF).Results: The NLR and RDW levels were found to be statisticallysignificantly higher in the BD group compared to the healthycontrol group. MPV levels were lower in the BD group than in thecontrol group. The level of hemogram parameters were similar inactive and inactive disease. NLR and PDW values were found to bestatistically higher in the BD group with major organ involvementgroup compared to the mucocutaneous BD group.Conclusions: The present study results demonstrated thatinflammatory indicators may not provide enough informationabout disease activity in patients with BD. NLR and PDW bothshowed good association with major organ involvement in BD.NLR was found to be much more suitable to follow up patientswith uveitis, MPV for those with erythema nodosum and PDW forneuro-Behçet and oral ulcers.

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