Erişkin Hastalarda Akut Komplike Apandisit Tanısında Yeni Bir Belirteç: Nötrofil/Albümin Oranı

Amaç: Çalışmamız, akut apandisit (AA) ile akut komplike apandisit (ACA) arasında ayrım yapmada nötrofil/albümin oranının (NAR) etkinliğini araştırmayı ve ACA tanısında nötrofil/albümin oranının (NAR) en iyi kesme noktasını bulmayı amaçlamaktadır. Materyal ve metod: Araştırmacı, bu çalışmayı apendektomi geçirmiş yetişkin 453 hastanın verilerini kullanarak gerçekleştirdi. Demografik veriler, preoperatif beyaz küre sayısı (WBC), nötrofil lenfosit oranı (NLR), nötrofil/albümin oranı (NAR), C-reaktif protein değeri (CRP) cerrahi sonuçları ve patolojik sonuçlar geriye dönük olarak değerlendirildi. Yazarlar hastaları AA ve ACA şeklinde iki gruba ayırmıştır. Sonuçlar: Çalışmamızda AA grubu 362, ACA grubu 91 hastadan oluştu. WBC, NLR, CRP ve NAR, akut apandisit ile akut komplike apandisit ayrımında önemli parametrelerdi. Bu parametreler arasında NAR; AUROC duyarlılık ve özgüllük değerleri diğerlerinden daha güçlüydü. (AUROC: 0.963, duyarlılık: %95.6, özgüllük: %85.7). ROC eğrisi analizi sonucunda 2,79 mg/dl cut-off değeri bulundu. Sonuç: NAR, ek zaman ve maliyet gerektirmeyen, rutin preoperatif kan sonuçlarıyla kolayca saptanan yeni bir inflamatuar belirteçtir. Nötrofil/albümin oranı (NAR), AA'yı ACA'dan ayırt etmek için hızlı, erişimi kolay ve güvenilir bir parametredir

Anahtar Kelimeler:

Apandisit, nötrofil/albümin oranı, tanı

A New Marker In The Diagnosis Of Acute Complicated Appendicitis In Adult Patients: Neutrophil/Albumin Ratio

ABSTRACT Aim: Our study aims to search the effectiveness of neutrophil/albumin ratio (NAR) in distinguishing between acute appendicitis (AA) and acute complicated appendicitis (ACA) and to find the best cut-off point of neutrophil/albumin ratio (NAR) for the diagnosis of ACA. Material and method: This study was performed using data from 453 adult patient who underwent appendectomy and divided into two groups as AA and ACA. Demographic data, preoperative white blood cell count (WBC), neutrophil lymphocyte ratio (NLR), neutrophil/albumin ratio (NAR), C-reactive protein value (CRP) surgical outcomes, and pathological outcomes were retrospectively assessed for each groups. Results: In our study, 362 patients were in the AA group and 91 patients were in the ACA group. WBC, NLR, CRP and NAR were significant parameters in differentiating acute appendicitis from acute complicated appendicitis. Among these parameters, NAR; AUROC sensitivity and specificity values were stronger than others. (AUROC: 0.963, sensitivity: 95.6%, specificity: 85.7%). As a result of the ROC curve analysis, a cut-off value of 2.79 mg/dl was found. Conclusion: NAR is a novel inflammatory marker simply detected through routine preoperative blood results, with no additional time or cost. The neutrophil/albumin ratio (NAR) is a fast, easy to access and reliable parameter to differentiate AA from ACA.

Keywords:

Appendicitis, neutrophil/albumin ratio, diagnosis,

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