Heves KARAGÖZ, Elif BAŞGÜL, Varol ÇELİKER, Ülkü AYPAR

İnhalasyon anesteziklerinin serum melatonin düzeylerine etkisi

Anestezinin ve pineal bez kaynaklı bir hormon olan melatoninin uyku ve davranışları etkilediği gösterilmiştir. Bu çalışma, halotan, izofluran ve sevofluran anestezilerinin endojen melatonin düzeylerine etkisini karşılaştırmayı amaçlamaktadır. Laparaskopik kolesistektomi planlanan 46 hasta, tiyopental, veküronyum ve fentanil ile anestezi indüksiyonu sağlandıktan sonra rastgele üç gruba ayrıldı. Anestezi idamesine I. grupta halotan (Grup H, n=16), II. grupta izofluran (Grup İ, n=15) ve III. grupta sevofluran (Grup S, n=15) ve N2O/O2 karışımı ile devam edildi. Anestezi sırasında hastaların gözleri ışığın etkisini önlemek için bantla kapatıldı. Operasyondan önceki gece 02m'de, indüksiyondan önce ve indüksiyondan sonraki 15. dakika'da ve ekstübasyondan hemen sonra serum melatonin düzeylerini saptamak için venöz kan örnekleri alındı. Melatoninin sırkadyan ritmine benzer şekilde genel anestezi sırasında düştüğü ve ekstübasyon sonrası da düşük kaldığı görüldü. Gruplar arasında serum melatonin düzeyleri bakımından fark bulunamadı. Sonuç olarak, çalışmamızda uyguladığımız her üç İnhalasyon anestezik ajanın serum melatonin düzeylerini etkilemediği ve üç grup arasında serum melatonin düzeyleri bakımından fark olmadığı kanısına varıldı.

Anahtar Kelimeler:

Anestezikler, inhalasyon, İzofluran, Halotan, Melatonin

The effect of inhalation anesthetics on serum melatonin levels

The pineal hormone melatonin and anesthetic agents affect sleep and behaviour. We aimed to compare the effects of halothane, isoflurane and sevoflurane on endogen melatonin levels in 46 patients scheduled for laparoscopic cholecystectomy. Patients were randomly assigned to three groups. General anesthesia was induced with thiopentone/vecuroniumlfentanyl. in the firstgroup, anesthesia was achieved with halothane (Group H, n=16), in the second group with isoflurane (Group I, n=15) and in the third group with sevoflurane (Group S, n=15) in N2O / O2 in all groups. During anesthesia, the patients eyes were carefully taped to prevent the effects of light. To detect the melatonin levels, blood samples were taken at 02°° a.m., before induction, 15 minutes after induction, andjust after extubation. in our study similar to the circadian rhythm of melatonin, plasma melatonin level ecreased, and remained at the same level after extubation. There were no differences in circulatory melatonin levels among the groups. We concluded that, these three anesthetic agents used in our study did not effect the level of melatonin and there were no differences in circulatory melatonin levels among the groups.

Keywords:

Anesthetics, Inhalation, Isoflurane, Halothane, Melatonin,

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