Meyancı Güniz KÖKSAL, Elif AŞKIN, HÜSEYİN ÖZ

Hidroklorik asit ile akut akciğer hasarı oluşturulan sağlıklı tavşanlarda intravenöz ve intratrakeal pentoksifilin kullanımının hemodinami ve kompliyans üzerine etkileri

Çalışmamızda, tavşanlarda intratrakeal (İT) hidroklorik asitle (HCl) oluşturulan akut akciğer hasarında intravenöz ve İT pentoksifilinin hemodinami ve kompliyans üzerine etkilerini araştırmayı amaçladık. 21 Yeni Zelanda tavşanı rasgele 3 eşit gruba ayrıldı (n:7). Tavşanlara ketamin hidroklorür ile sedasyonu takiben trakeostomi açıldı. İnvaziv arter monitörizasyonu yapıldı. Tavşanlar 180 dk, FiO2: 1.0, Peak inspiratuar basınç:15 cmH2O, PEEP: 5 cmH2O, I / E: 1/2, frekans: başlangıç PaCO2:35-45 mmHg olacak şekilde ayarlanarak ventile edildi. Çalışmanın başında hemodinamik parametreler ve kompliyans ölçümü yapıldıktan sonra, tüm tavşanlara 2 mL kg-1 HCl İT uygulandı. 5 dk sonra; Grup I 'e iv, Grup ll'ye 20 mg/kg İT pentoksifilin uygulandı. Grup III'e tedavi uygulanmadı. Hemodinamik parametrelerin ve kompliyansın ölçümü 60 dk aralıklarla yapıldı. Üçüncü grubun ortalama arter basıncı 180.dk'da I.gruba göre düşüktü (p

Anahtar Kelimeler:

Tavşanlar, Modeller, teorik, Pentoksifilin, Modeller, hayvan

The effects of intravenous and intratracheal pentoxifylline on hemodynamic parameters and lung compliance in hydrochloric acid-induced acute lung injury in rabbits

In current study we aimed to investigate the effects of intravenous (iv) and intratracheal pentoxifylline (PTXF) on hemodynamic parameteres (mean arterial pressure, heart rate) and lung compliance, in hydrocholoric acid (HCl)-induced acute lung injury (ALI) model in rabbits. 21 New Zealand rabbits were randomly assigned into 3 groups (n:7). Tracheostomy was performed, following sedation with ketamine and invazive monitorization was established. The rabbits were ventilated for 180 min with parametres; FiO2:1.0, PIP: 15 cmH2O, PEEP:5 cmH2O, I/E:1/2 and respiratory rate was adjusted to produce initial PaCO2 35-40 mmHg. After the measurement of hemodynamic parameters, lung compliance values, 2 mL/kg HCl was administered via IT route. 5 min after HCl application; group I; received 20 mg/kg iv PTXF and group II; 20 mg/kg IT PTXF, group III; was the control group, without any treatment. Hemodynamic parameters and lung compliance values were recorded every 60 min. There were no difference between groups in heart rate. Mean arterial pressure (MAP) at 180 min in group III was found to be lower than groups I and II (p<0.01, p<0.05 respectively). Also lung compliance values at 60, 120, 180 min in group III were lower than group I and II (p<0.01, p<0.01, respectively). To conclude, iv and IT PTXF may ameliorate hemodynamic parameters and may have protective effect on lung compliance, in HCl acid-induced ALI model in rabbits.

Keywords:

Rabbits, Models, Theoretical, Pentoxifylline, Models, Animal,

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