Amanjot Singh, Kewal Krishan Gupta, Amarjeet Kaur, Haramritpal Kaur

Çocuklarda İnfraumbilikal Cerrahilerde Kaudal Levobupivakaine Adjuvan Olarak Deksmedetomidin Eklenmesinin Analjezik Etkinlik ve Güvenirliği

Amaç: Ameliyat sonrası ağrı yönetimi, anestezi bakımının ayrılmaz bir parçası haline gelmektedir. Tek seferlik kaudal blok, pediatrik analjezi için yaygın bir tekniktir, ancak kısa etki süresi dezavantajıdır. Kaudal analjezi süresini uzatmak için pek çok adjuvan kullanılmıştır. Bu nedenle bu çalışmayı, çocuklarda kaudal blokta kullanılan levobupivakaine adjuvan olarak deksmedetomidin eklenmesinin analjezik etkinliği, postoperatif analjezi süresi, hemodinamik stabilite ve herhangi bir yan etkisi olup olmadığını değerlendirmek için tasarladık. Yöntem: Kurumsal etik kurul onayı ve ebeveynlerden yazılı bilgilendirilmiş onam alındıktan sonra bu prospektif, çift kör çalışma, 1-12 yaş arası elektif subumblikal cerrahi planlanan 80 çocuk, rastgele iki gruptan birine dahil edilerek gerçekleştirildi. Grup A’daki çocuklara 0.5 mL normal salin ile birlikte %0.25 levobupivakain 1 mL kg-1, Grup B’ye ise 0.5 mL normal salin içinde 1 µg kg-1 deksmedetomidin ile birlikte %0.25 levobupivakain 1 mL kg-1 olacak şekilde kaudal ilaç karışımı verildi. Bulgular: Ortalama analjezi süresi Grup A’da 324±55.6 dk ve Grup B’de 678±170.9 dk olup fark istatistiksel olarak anlamlıydı (p

Analgesic Efficacy and Safety of Dexmedetomidine as an Adjuvant to Caudal Levobupivacaine for Infraumbilical Surgeries in Children

Objective: Postoperative pain management is becoming an integral part of anaesthesia care. Single shot caudal block is a common technique for paediatric analgesia but with the disadvantage of short duration of action. Several adjuvants have been used to prolong the duration of caudal analgesia. So we designed this study using dexmedetomidine as an adjuvant with levobupicaine for caudal block to assess analgesic efficacy, duration of postoperative analgesia, hemodynamic stability and any adverse effects in children. Methods: After getting approval by Institutional Ethical Committee and written informed consent from parents, this prospective, double blind trial was carried on 80 children aged between 1 to 12 years scheduled for elective subumbilical surgeries that were allocated randomly into one of two groups. Children in Group A received 0.25% levobupivacaine 1 mL kg-1 body weight with 0.5 mL normal saline and in Group B received 0.25% levobupivacaine 1 mL kg-1 body weight with dexmedetomidine 1 mL kg-1 in 0.5 mL normal saline as caudal drug mixture. Results: The mean duration of analgesia in Group A was 324.±55.6 min and in Group B was 678±170.9 min which was statistically significant (p

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