Mehmet DUVARCI, Aykut DEMİRCİ, Fatih HIZLI, Halil BAŞAR, Murat BEYATLI, Feyza BEYATLI

Varikoseli olan hastalarda nötrofil/lenfosit oranı (NLR), platelet/ lenfosit oranı (PLR), monosit/eozinofil oranı (MER) gibi enflamatuvar belirteçlerin varikoselektomi sonrası spermiogram parametrelerinin değişimine etkisini öngörme

AMAÇ: Mikroskopik varikoselektomi (MV) yapılan hastalarda enflama- tuvar kan belirteçleri kullanılarak ameliyat sonrası spermiogram para- metrelerindeki değişimi tahmin etmektir. GEREÇ ve YÖNTEMLER: Kliniğimizde MV yapılan 25 hasta çalışmaya dâhil edildi. Hemogram parametreleri ameliyattan hemen önce ve yir- mi gün sonra, spermiyogram parametreleri ise ameliyattan altı ay sonra ölçüldü. Hastalar iki gruba ayrıldı. Ameliyat sonrası Toplam Hareketli Sperm Sayısında (TMS) >%50 iyileşme olan hastalar iyileşen hasta gru- buna, %50’den az iyileşme olan hastalar ise iyileşmeyen hasta grubuna dâhil edildi. Nötrofil/lenfosit (NLR), trombosit/lenfosit (PLR), mono - sit/eozinofil (MER) oranları gruplar arasında karşılaştırıldı. BULGULAR: Ameliyat sonrası NLR’de istatistiki olarak anlamlı dü - şüş olan hastalarda TMS’de iyileşme olduğu görülmüştür (p=0,009). Nötrofil/lenfosit değişimi için elde edilen cut-off noktası %1,06 ve üzeri olarak saptanmıştır. Trombosit/lenfosit ve MER parametreleri ise TMS’nin iyileşmesini öngörmede istatistiki olarak anlamlı değildir (p>0,05). Ameliyat sonrasında TMS’de iyileşme olan hastalarda ameliyat öncesi nötrofil ve monosit sayıları daha yüksek bulundu ve bu para - metreler için cut-off değerleri sırasıyla 3,77 ve 0,47 olarak tespit edildi (p

Prediction of the effect of inflammatory markers such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/eosinophil ratio (MER) on changes in spermiogram parameters after varicocele surgery

OBJECTIVE: In this study, we aimed to predict the changes in postoperative spermiogram parameters in patients who underwent varicocelectomy by using pre- and post-operative hemogram parameters and inflammatory blood markers. MATRERIAL and METHODS: 25 patients who underwent microscopic varicocelectomy in our clinic and met the study criteria were included in the study. Hemogram parameters were measured just before and twenty (20) days after the surgery, and spermiogram parameters were measured 6 months after the surgery. The patients seperated into two groups. Patients with >50% improvement in postoperative Total Motile Sperm Count (TMS) were included in the recovered patients group, and patients with less than 50% improvement were included in the non-recovered patients group. Neutrophil / lymphocyte ratio (NLR), platelet / lymphocyte ratio (PLR), monocyte / eosinophil ratio (MER), and blood counts such as neutrophil, lymphocyte, platelet, monocyte, eosinophil were compared in groups, also were compared before and after surgery, separate RESULTS: Improvement in TMS was observed in patients with a statistically significant decrease in postoperative NLR (p = 0.009; p

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