Sercan ERGÜN, Neslihan HEKİM, Sezgin GÜNEŞ

Erkek infertilitesi ve kanser arasındakigenetik örtüşme

Erkek infertilitesi heterojen ve multifaktöriyel etiyolojili bir bozukluktur. Son yıllarda yapılan bazı çalışmalar erkek infertilitesinin yalnızca sperm üretimindeki bir bozukluktan kaynaklanmadığı, bazı olgularda diyabet, kardiyovasküler hastalıklar ve kanser gibi sistemik bir bozukluğun bir parçası olabileceğini göstermektedir. Spermatogenez sürecindeki çok sayıdaki mitoz ve mayoz bölünmeler ve bazı çevresel faktörler, mutasyon/mutasyonlara neden olabilir ve kansere yol açabilir. Bu nedenlerle, erkek infertilitesi aslında kanser için bir erken belirteç olabilir. Bu derlemede erkek infertiltesi ve kanser arasındaki ortak genomik bulgular değerlendirildi.

Genetic overlap between male infertility and cancer

Male infertility is a highly heterogeneous disorder with multifactorialaetiology. Recent data have demonstrated that male infertility is notonly an aberration in sperm production; however, infertility might bea part of various systemic diseases including diabetes, cardiovascularand cancer in some cases of infertility. High number of cell division bymitosis and meiosis during spermatogenesis and various environmentalfactors may lead to mutation/mutations result in cancer. Therefore,infertility might be an early marker for male infertility. This studyreviews common genomic data regarding cancer and male infertility.

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