Engin KÖLÜKÇÜ, İlker ETİKAN, Velid UNSAL, Nihat ULUOCAK

Adölesan varikosel ile ortalama trombosit hacminin ilişkisi

Amaç: Bu çalışmada adölesan varikosel ile ortalama trombosit hacmi (MPV) arasında ilişkinin araştırılması hedeflenmiştir.Gereç ve Yöntemler: Hastalar iki grup halinde ele alındı. Grup 1; kontrol grubu olarak belirlendi. Grup 2 ise 11-19 yaş aralığında grade 3 varikosel tanısı konulan olgulardan oluşmaktaydı. Her iki grubun MPV değerleri istatiksel olarak karşılaştırıldı. Bulgular: Ocak 2012 ve Şubat 2018 tarihleri arasında 102 hasta çalışmaya dahil edildi. Hastaların yaş ortalaması 15.12 ± 2.12 yıl idi. Her iki grup arasında yaş ortalamaları ve dağımları açısından istatiksel farklılık izlenmedi (p>0.05). Grup 1 ve 2 için MPV değerler sırası ile 8.09±0.69 ve 9.65±1.6 olarak hesaplandı. Grup 2’de ölçülen MPV değeri grup 1 göre istatiksel olarak anlamlı olarak yüksek izlendi (p<0.001). Sonuç: Çalışmamızda adölesan varikosel ile MPV arasında anlamlı ilişki olduğu gösterilmiştir. Gelecekte varikosel patofizyoloji hakında yapılacak yeni araştırmalarda MPV yüksekliğinin bir rehber olarak kullanılabileceğini düşünmekteyiz.

Anahtar Kelimeler:

Adölesan, varikosel, ortalama, trombosit, hacmi

Relationship between adolescent varicocele and mean platelet volume

Objectives: The aim of this study is to investigate the relationship between adolescent varicocele and mean platelet volume (MPV).Materials and Methods: Patients were divided into two groups. Group 1 was determined as the control group. Group 2 consisted of patients between the ages of 11-19 who were diagnosed with Grade 3 varicocele. MPV values of both groups were statistically compared.Results: Between January 2012 and February 2018, 102 patients were included in the study. The mean age of the patients was 15.12 ± 2.12 years. No statistically significant difference was found between the two groups in terms of mean ages and their distribution (p> 0.05). MPV values for Groups 1 and 2 were 8.09 ± 0.69 and 9.65 ± 1.6, respectively. MPV values measured in Group 2 were significantly higher than group 1 (p<0.001). Conclusions: In our study, there was a significant relationship between adolescent varicocele and MPV. We believe that MPV elevation can be used as a guide in future studies performed on varicocele pathophysiology.

Keywords:

Adolescent, varicocele, mean, platelet, volume,

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Referans1- Richardson I, Grotas AB, Nagler HM. Outcomes of varicocelectomy treatment: an updated critical analysis. Urol Clin North Am. 2008;35:191-209. DOI: 10.1016/j.ucl.2008.01.007.
Referans2- Dohle GR, Glassberg KI. How common are varicocoeles? New data on the prevalence in adolescence and new discussions. Andrology. 2013;1:661–2. DOI: 10.1111/j.2047-2927.2013.00128.x.
Referans3- Akbay E, Cayan S, Doruk E, Bozlu M. The prevalence of varicocele and varicocele-related testicular atrophy in Turkish children and adolescents. BJU Int 2000 ;86(4):490-3.
Referans4- Dubin L, Amelar R.D. Varicocele size and results of varicocelectomy in selected subfertile men with varicocele. Fertil Steril. 1970;21:606-60.
Referans5- Ersöz G. Platelet Activation. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1997;3:163-172.
Referans6- Briggs C, Harrison P, Machin SJ: Continuing developments with the automated platelet count. Int J Lab Haematol. 2007;29:1-15.
Referans7- Sandhaus LM, Meyer P. How useful are CBC and reticulocyte reports to clinicians? Am J Clin Pathol. 2002;118: 787-93. DOI: 10.1309/CQGG-HY0U-LRKL-GLMP.
Referans8- Endler G, Klimesch A, Sunder-Plasmann H, Schillinger M, Exner M, Mannhalter C, et al. Mean platetet volume is an independent risk factor for myocardial infarction but for coro-nary artery disease. Br J Hmaemotal 2002;117:399-404. DOI: 10.1046/j.1365-2141.2002.03441.x.
Referans9- Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arth-ritis. Joint Bone Spine. 2008;75(3):291-4. DOI: 10.1016/j.jbspin. 2007.06.016.
Referans10- Beyan C, Beyan E. Mean platelet volume and amyloidosis in patients with familial Medi-terranean fever. Clin Rheumatol. 2013;32(8):1245-6. DOI: 10.1007/s10067-013-2313-4.
Referans11- Shilpi K, Potekar RM. A Study of Platelet Indices in Type 2 Diabetes Mellitus Patients. In-dian J Hematol Blood Transfus. 2018;34(1):115-120. DOI: 10.1007/s12288-017-0825.
Referans12- Nöske HD, Weidner W. Varicocele–a historical perspective. World J Urol 1999:151-7.
Referans13- Erdemir F, Kılıç S. Varicocele. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi 2011;3(2):1-11.
Referans14- Çayan S, Kadıoğlu A. Current Approaches In The Diagnosis And Treatment Of Varicocele. Turk J Urol. 2005;31(1):57-63.
Referans15- Öztürk E, Soygür T. Adölesan varikosel (Derleme). Androloji Bülteni. 2013;53:103-5.
Referans16- Kohler FP. On the etiology of varicocele. J Urol. 1967;97(4):741-2.
Referans17- Kiliç S, Aksoy Y, Sincer I, Oğuz F, Erdil N, Yetkin E. Cardiovascular evaluation of young patients with varicocele. Fertil Steril. 2007;88(2):369-73. DOI: 10.1016/j.fertnstert.2006.11.119.
Referans18- Yetkin E, Kilic S, Acikgoz N, Ergin H, Aksoy Y, Sincer I et al. Increased prevalence of va-ricocele in patients with coronary artery ectasia. Coron Artery Dis. 2005;16(5):261-4.
Referans19- Koyuncu H, Ergenoglu M, Yencilek F, Gulcan N, Tasdelen N, Yencilek E et al. The evalua-tion of saphenofemoral insufficiency in primary adult varicocele. J Androl. 2011;32(2):151-4. DOI: 10.2164/jandrol.109.009258.
Referans20- Ciaccio V, Ficola F, Ceccarelli F, Capodicasa E. [Assessment of sapheno-femoral junction continence in 42 patients with primary varicocele]. Minerva Chir. 1995;50(5):469-73.
Referans21- Özkan MTA, Seyhah S, Özdemir S. Incidence of Venous Insufficiency in Patients with Va-ricocele. International Journal of Clinical Research 2014;2(4):156-9.
Referans22- Ayan NN, Savaş Z, Bireroğlu N, Keleş A, Aksoy N, Serin Ö. The Comparison of Platelet Counts between the before and after Treatments of Women with Iron Deficiency Anemia JAREM. 2015; 5: 94-6 DOI: 10.5152/jarem.2015.712.
Referans23- Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Meanplatelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011;17:47-58.
Referans24- Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med. 2007;357:2482-94. DOI: 10.1056/NEJMra071014.
Referans25- Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996;7(2):157-61.
Referans26- Toptaş M, Durmuş G, Akkoç İ, Öztürk S, Şahin M, Belen E et al. Are Mean Platelet Volume and Platelet Count Associated with Presence of Thrombus in Patients with Abdominal Aor-tic Aneursym? Med Bull Haseki 2018;56:32-6. DOI: 10.4274/haseki.80299.
Referans27- Korkmaz L, Korkmaz AA, Akyüz AR, Ağaç MT, Acar Z, Kırış A. et al. Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: an observational study. Anadolu Kardiyol Derg. 2012;12:35-9.
Referans28- Sarıca MA, Kızıldağ B, Selçuk MY, Tutak AŞ, Baykan AH, Bulut HT et al. Mean Platelet Volume in Patients with Chronic Venous Insufficiency. Journal of Clinical and Experimen-tal Investigations 2016;7(1):73-7. DOI: 10.5799/ahinjs.01.2016.01.0573.
Referans29- Deveci Ş, Çelebi A, Aşkın S, Gürsoy AE, Kolukısa M, Hakyemez A. Relationship of mean platelet volume to an acute ischemic stroke. Ege Journal of Medicine 2014;53(1):1-6.
Referans30- Bozkurt Y, Soylemez H, Sancaktutar AA, Islamoglu Y, Kar A, Penbegul N et al. Relations-hip between mean platelet volume and varicocele: a preliminary study. Urology. 2012;79(5):1048-51. DOI: 10.1016/j.urology.2012.01.019.
Referans31- Çoban S, Keleş I, Biyik I, Güzelsoy M, Türkoğlu AR, Özgünay T et al. Is there any relati-onship between mean platelet volume and varicocele? Andrologia. 2015;47(1):37-41. DOI: 10.1111/and.12220.
Referans32- Çoban S, Keles I, Biyik İ, Guzelsoy M, Turkoglu AR, Ocak N. Does varicocele correction lead to normalization of preoperatively elevated mean platelet volume levels? Can Urol Assoc J. 2015;9(1-2):E5-9. DOI: 10.5489/cuaj.2113.
Referans33- Mahdavi-Zafarghandi R, Shakiba B, Keramati MR, Tavakkoli M. Platelet volume indices in patients with varicocele. Clin Exp Reprod Med. 2014;41(2):92-5. DOI: 10.5653/cerm.2014.41.2.92.
Referans34- Camoglio FS, Peretti M, Bianchi F, Mariotto A, Zampieri N. Mean platelet volume and va-ricocele: comparison between adolescents and adults. Am J Clin Exp Urol. 2015;3(2):100-6.
Referans35- Okçelik S, Gök M, Şener İ, Ateş F, Soydan H, Yılmaz Ö et al. The relationship between va-ricocele and mean platelet volume levels is still not clear. The New Journal of Urology 2017;12 (2):17-20.

Yayın Aralığı: Yılda 4 Sayı
Başlangıç: 2019
Yayıncı: MediHealth Academy Yayıncılık

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