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Türk Bir Popülasyonda Normal Tiroid Teknesyum99m Perteknetat Alım Aralığının Belirlenmesi

Amaç: Bu çalışmada Türk bir popülasyonda normal tiroid teknesyum-99m perteknetat alım aralığını belirlemek amaçlanmıştır. Yöntem: Retrospektif çalışmamız paratiroid adenom lokalizasyonu için uygulanan paratiroid sintigrafisinin bir bileşeni olarak teknesyum-99m perteknetat ile tiroid sintigrafisi yapılan ardışık 73 (54 kadın, 19 erkek) ötiroid hasta içerdi. Her hasta için 20. dakikada tiroid teknesyum99m perteknetat alım değeri hesaplandı. Bulgular: Ortalama hasta yaşı 56,4±15,2 yıl, ortalama tiroid uyarıcı hormon düzeyi 1,15±0,48 uIU/mL idi. Medyan ve çeyrekler arası aralık teknesyum-99m perteknetat alım değerleri sırasıyla %0,8 ve %0,56–1,15 idi. Belirlenen normal tiroid teknesyum-99m perteknetat alım aralığı %0,26–1,64 oldu. Yaş ve teknesyum-99m perteknetat alımı arasında negatif korelasyon gözlendi (r=-0,33; p=0,002). Sonuç: Türkiye’de kullanımda olanlara kıyasla anlamlı biçimde daha düşük değerlere dayanan yeni normal tiroid teknesyum-99m perteknetat alım aralığımızın, İstanbul nüfusunda tiroid hastalıklarında tiroid fonksiyonu değerlendirmelerinde kullanılmaya uygun olduğu savındayız.

Determination of the Normal Range for Thyroid Uptake of Technetium-99m Pertechnetate in a Turkish population

Aim: This study aimed to determine the normal range for thyroid uptake of technetium-99m (99mTc) pertechnetate in a Turkish population. Methods: The retrospective study included 73 (54 females, 19 males) consecutive euthyroid patients, all of whom underwent thyroid scintigraphy using 99mTc-pertechnetate as a component of parathyroid scintigraphy for parathyroid adenoma localization. The value of thyroid uptake of 99mTc-pertechnetate at the 20th minute was calculated for each patient. Results: The mean patient age was 56.4±15.2 years; the mean thyroid-stimulating hormone level was 1.15±0.48 uIU/mL. The median and interquartile range values of 99mTc-pertechnetate uptake were 0.8% and 0.56–1.15%, respectively. The normal range for thyroid uptake of 99mTc-pertechnetate was determined to be 0.26–1.64%. There was a negative correlation between 99mTc-pertechnetate uptake and age (r =-0.33, p=0.002). Conclusion: We propose that our new normal range for thyroid uptake of 99mTc-pertechnetate based on significantly lower values compared with those currently in use in Turkey is appropriate for use to evaluate thyroid function in thyroid disorders in the population of Istanbul.

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