Şizofreni Hastalarında Klinik Semptomların Obsesif Kompülsif Bozukluk Eş Tanısıyla ve Obsesif Kompülsif Semptomlarla İlişkisinin Değerlendirilmesi

Amaç: Şizofrenide obsesif kompülsif semptomların (OKS) ve obsesif kompülsif bozukluğun (OKB) görülme sıklığı yüksek olup; şizofrenide OKS/OKB eş tanısının özelliklerini araştıran çalışmalarda çelişkili sonuçlar elde edilmiştir. Bu çalışmada şizofreni hastalarında OKS/OKB eş tanısının sosyodemografik ve klinik özellikler ile ilişkisinin değerlendirilmesi amaçlanmıştır.

Assessing The Relationship Between Clinical Characteristics and Obsessive-Compulsive Disorder Comorbidity and Obsessive-Compulsive Symptoms in Patients With Schizophrenia

Aim: There is a high prevalence of obsessive-compulsive symptoms (OCS) and obsessive-compulsive disorder (OCD) comorbidity in patients with schizophrenia. Previous studies investigating the OCS/OCD comorbidity in schizophrenia have obtained conflicting results. The aim of this study was to investigate the relationship between OCS/OCD comorbidity, and sociodemographic variables and clinical symptoms in patients with schizophrenia.

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  • 1. Fernandez-Egea E, Worbe Y, Bernardo M, Robbins TW. Distinct risk factors for obsessive and compulsive symptoms in chronic schizophrenia. Psychol Med. 2018; 19: 1-8.
  • 2. Zhou T, Baytunca B, Yu X, Ongür D. Schizo-obsessive disorder: the epidemiology, diagnosis, and treatment of comorbid schizophrenia and OCD. Curr Treat Options Psychiatry 2016; 3: 235–245.
  • 3. Kazhungil F, Kumar KJ, Viswanath B, Shankar RG, Kandavel T, Math SB. Neuropsychological profile of schizophrenia with and without obsessive compulsive disorder. Asian J Psychiatr. 2017; 29: 30-34.
  • 4. Scotti-Muzzi E, Saide OL. Schizo-obsessive spectrum disorders: an update. CNS Spectr. 2017; 22: 258-272.
  • 5. Cunill R, Castells X, Simeon D. Relationships between obsessive–compulsive symptomatology and severity of psychosis in schizophrenia: a systematic review and meta-analysis. J Clin Psychiatry 2009; 70: 70-82.
  • 6. Grover S, Dua D, Chakrabarti S, Avasthi A. Obsessive Compulsive Symptoms/disorder in patients with schizophrenia: Prevalence, relationship with other symptom dimensions and impact on functioning. Psychiatry Res. 2017; 250: 277-284.
  • 7. Doyle M, Chorcorain AN, Griffith E, Trimble T, O'Callaghan E. Obsessive compulsive symptoms in patients with schizophrenia on clozapine and with obsessive compulsive disorder: a comparison study. Compr Psychiatry 2014; 55: 130–136.
  • 8. Kayahan B, Ozturk O, Veznedaroglu B, Eraslan D. Obsessive compulsive symptoms in schizophrenia: prevalence and clinical correlates. Psychiatry Clin Neurosci. 2005; 59: 291-295.
  • 9. Lysaker PH, Bryson GJ, Marks KA. Association of obsessions and compulsions in schizophrenia with neurocognition and negative symptoms. J Neuropsychiatry Clin Neurosci. 2002; 14: 449-453.
  • 10. Schirmbeck F, Swets M, Meijer CJ, Zink M, de Haan L; GROUP investigators. Obsessive–compulsive symptoms and overall psychopathology in psychotic disorders: longitudinal assessment of patients and siblings. Eur Arch Psychiatry Clin Neurosci. 2018; 268: 279-289.
  • 11. Tonna M, Ottoni R, Affaticati A, Ferrari L, Monici A, Ossola P. The impact of obsessive dimension on symptoms and functioning in schizophrenia. Psychiatry Res. 2015; 230: 581-584.
  • 12. McNally RJ, Mair P, Mugno BL, Riemann BC. Co-morbid obsessive–compulsive disorder and depression: a Bayesian network approach. Psychol Med. 2017; 47(7): 1204–1214.
  • 13. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. (2013). 5th ed. Washington D.C.
  • 14. Overall JE, Gorham DR. The brief psychiatric rating scale (BPRS): recent developments in ascertainment and scaling. Psychopharmacol Bull. 1988; 24: 97-99.
  • 15. Guy W. (1976 ECDEU Assessment Manual for Psychopharmacology. Rockville, MD: US Department of Heath, Education, and Welfare Public Health Service Alcohol, Drug Abuse, and Mental Health Administration.
  • 16. Andreasen NC. Methods for assessing positive and negative symptoms. Mod Probl Pharmacopsychiatry 1990; 24: 73–88.
  • 17. Addington D, Addington J, Schissel B. A depression rating scale for schizophrenics. Schizophr Res. 1990; 3: 247-251.
  • 18. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL. The Yale-Brown Obsessive Compulsive Scale. Development, Use, and Reliability. Arch Gen Psychiatry 1989; 46: 1006–1011.
  • 19. Endicott J, Spitzer RL, Fleiss JL, Cohen J. The Global Assessment Scale: A Procedure for Measuring Overall Severity of Psychiatric Disturbance. Arch Gen Psychiatry 1976; 33: 766-771.
  • 20. David A, Buchanan A, Reed A. Assessment of insight in psychosis. Br J Psychiatry 1992; 161: 599-602. DOI: 10.1192/bjp.161.5.599
  • 21. IBM Corp. Released (2012). IBM SPSS Statistics for Windows, Version 21.0. Armonk, NY: IBM Corp.
  • 22. Rajkumar RP, Reddy YC, Kandavel T. Clinical profile of "schizo-obsessive" disorder: a comparative study. Compr Psychiatry 2008; 49(3): 262-268.
  • 23. Owashi T, Ota A, Otsubo T, Susa Y, Kamijima K. Obsessive-compulsive disorder and obsessive-compulsive symptoms in Japanese inpatients with chronic schizophrenia- a possible schizophrenic subtype. Psychiatry Res. 2010; 179: 241–246.
  • 24. Sharma LP, Reddy Y. Obsessive-compulsive disorder comorbid with schizophrenia and bipolar disorder. Indian Journal of Psychiatry 2019; 61(Suppl 1): 140–148.
  • 25. Kim JH, Ryu S, Nam HJ, Lim M, Baek JH, Joo YH. Symptom structure of antipsychotic-induced obsessive compulsive symptoms in schizophrenia patients. Prog Neuropsychopharmacol Biol Psychiatry 2012; 39: 75–79.
  • 26. Schirmbeck F, Zink M. Comorbid obsessive-compulsive symptoms in schizophrenia: contributions of pharmacological and genetic factors. Front Pharmacol. 2013; 4: 99.
  • 27. Poyurovsky M. Faragian S, Shabeta A, Kosov A. Comparison of clinical characteristics, co-morbidity and pharmacotherapy in adolescent schizophrenia patients with and without obsessive-compulsive disorder. Psychiatry Res. 2008; 159: 133–139.
  • 28. Ongur D, Goff DC. Obsessive-compulsive symptoms in schizophrenia: associated clinical features, cognitive function and medication status. Schizophr Res. 2005; 75: 349-362.
  • 29. Swets M, Dekker J, van Emmerik-van Oortmerssen K, Smid GE, Smit F, de Haan L, et al. The obsessive compulsive spectrum in schizophrenia, a meta-analysis and meta-regression exploring prevalence rates. Schizophr Res. 2014; 152: 458–468.
  • 30. Poyurovsky M, Hramenkov S, Isakov V, Rauchverger B, Modai I, Schneidman M, et al. Obsessive-compulsive disorder in hospitalized patients with chronic schizophrenia. Psychiatry Research 2000; 102(1): 49-57.
  • 31. Byerly M, Goodman W, Acholonu W, Bungno R, Rush AJ. Obsessive compulsive symptoms in schizophrenia: Frequency and clinical features. Schizophr Res. 2005; 76: 309-316.
  • 32. Faragian S, Kurs R, Poyurovsky M. Insight into obsessive–compulsive symptoms and awareness of illness in adolescent schizophrenia patients with and without OCD. Child Psychiatry Hum Dev. 2008; 39: 39-48.
  • 33. Zink M. Comorbid obsessive‑compulsive symptoms in schizophrenia: Insight into pathomechanisms facilitates treatment. Adv Med. 2014; 317980.
  • 34. Baytunca B, Kalyoncu T, Ozel I, Erermiş S, Kayahan B, Öngur D. Early Onset Schizophrenia Associated With Obsessive-Compulsive Disorder: Clinical Features and Correlates. Clin Neuropharmacol. 2017; 40: 243-245.
  • 35. de Haan L, Sterk B, Wouters L, Linszen DH. The 5-year course of obsessive-compulsive symptoms and obsessive-compulsive disorder in first-episode schizophrenia and related disorders. Schizophr Bull. 2013; 39: 151–160.
Anadolu Kliniği Tıp Bilimleri Dergisi-Cover
  • ISSN: 2149-5254
  • Yayın Aralığı: 3
  • Başlangıç: 1933
  • Yayıncı: Hayat Sağlık ve Sosyal Hizmetler Vakfı
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