Nilgun GULER ŞANOL, Gültekin Adanas AYDIN, Ismihan GURGEN

Postmenopozal Osteoporozda Laktasyon ve İlk Gestasyonel Yaşın Etkisi

Amaç: Postmenopozal osteoporozun (OP) etiyolojisinde çeşitli faktörler öne sürülmüştür. Bu çalışmada gebelik sayısı, emzirme ve ilk gebelik yaşının postmenopozal OP üzerindeki olası etkilerini araştırmak amaçlanmıştır.Gereç ve Yöntemler: Nisan 2015--Aralık 2015 döneminde 45-70 yaşlarındaki toplam 427 postmenopozal hasta OP taramasına alındı. Yaş, boy, kilo, menopoz ve menarş yaşı, kronik hastalık, eş zamanlı kullanılan ilaç, aile öyküsü, postmenopozal hormon tedavisi geçmişi, gebelik sayısı, doğum(lar) sırasındaki yaş ve (her) gebelikteki laktasyon dönemi bilgilerini edinmek amacıyla, tüm hastalara bir anket uygulandı. Kemik mineral yoğunluğu (KMY), dual enerjili X-ray absorbsiyometri kullanılarak ölçüldü; femur boyun, femur total, L1-L4 ve L2-L4 değerleri kaydedildi. Hastalar OP (n=73) ve OP olmayan grup (n=354) olarak ikiye ayrıldı.Bulgular: Gebelik sayısı OP grubunda OP olmayan gruba göre istatistiksel olarak daha yüksekti (p=0,037). Gruplar arasında nulliparite, primiparite ve multipariteye göre anlamlı fark yoktu. Tartışma ve Sonuç: Çalışmamızda elde edilen sonuçlar laktasyonun ve ilk gebelik yaşının postmenopozal OP gelişimine bir etkisi olmadığını göstermektedir.

Effects of Lactation and Age of First Pregnancy on Postmenopausal Osteoporosis

Aim: Several factors have been suggested in the etiology of postmenopausal osteoporosis (OP). In this study, we aimed to investigate the possible effects of lactation, number of pregnancies, and age of first pregnancy on postmenopausal OP.Materials and Methods: Four hundred and twenty-seven postmenopausal patients aged between 45 and 70 years were screened for OP between April 2015 and December 2015. A questionnaire was administered to all of the patients in order to obtain data about their age, height, weight, age of menopause and menarche, chronic illnesses, concomitant drug use, family history, postmenopausal hormone therapy history, number of pregnancies, childbearing age, and lactation period at each pregnancy. The bone mineral density (BMD) was measured by using dual-energy X-ray absorptiometry; measurements of the femoral neck, total femur and the lumbar vertebrae L1-L4 and L2-L4 were recorded. The patients were divided into two groups as those with OP (n=73) and those without OP (n=354).Results: The number of pregnancies was statistically higher in the OP group in comparison to the non-OP group (p=0.037). No significant difference was found between the groups in terms of nulliparity, primiparity, and multiparity.Discussion and Conclusion: The results of our study suggest that lactation and age of first pregnancy have no effect on developing postmenopausal OP.

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