Talat AYYILDIZ, Enver DOLAR, Barbaros ORAL, Şener ARIKAN, Saduman BALABAN

Non-Alkolik Yağlı Karaciğer Hastalığı Ve Serum Nesfatin-1 İlişkisi

Amaç: Nesfatin -1 anoreksijenik etkisi olan tokluk peptidi olarak tanımlanan yeni bir peptittir. Yapılan çalışmalarda metabolik sendrom ve insülin rezistansı ile ilişkisi olduğu ortaya konmuştur. Biz bu çalışma ile biyopsi tanılı non-alkolik yağlı karaciğer hastalığı (NAFLD) olan hastaların klinikopatolojik özellikleri ile Nesfatin-1 arasındaki ilşikiyi ortaya koymaya çalıştık. Gereç ve Yöntemler: Histolojik olarak non-alkolik yağlı karaciğer hastalığı tanısı konmuş 59 hasta ve 32 sağlıklı kontrol grubunda serum Nesfatin-1 seviyeleri enzyme-linked immunosorbent assay (ELISA) yöntemiyle ölçülmüştür. Bulgular: Serum Nesfatin-1 seviyesi non-alkolik yağlı karaciğer hastalığı olanlarla kontrol grubu arasında anlamlı farklılık göstermiyordu (p<0,170). Basit korelasyon analizinde vücut kitle indeks (VKİ) arttıkça nesfatin-1 seviyelerinin azaldığı (p=0.043) ve AST arttıkça nesfatin-1 değerlerinin de arttığı (p=0,05) görüldü. Çoklu regresyon modeli oluşturularak yapılan incelemede ise portal inflamasyon (B=10,767, p=0,007), VKİ skoru (B=-0,510, p<0,001) ve HDL kolesterol (B=-0,208, p<0,001) ile nesfatin-1 arasında negatif yönlü ilişki yaş (B=0,120, p=0,031), cinsiyet (erkeklerde kadınlara göre daha düşük) (B=-40,897, p<0,001) sistolik kan basıncı (B=0,063, P=0,050) ve aspartat aminotransferaz (B=0,033, p=0,019) arasında pozitif ve doğrusal anlamlı ilişki bulunmuştur. Sonuçlar: Özet olarak bulgular serum nesfatin-1 seviyesinin non-alkolik yağlı karaciğer hastalığında portal inflamasyonun bağımsız bir prediktörü olabileceğine işaret etmektedir.

Anahtar Kelimeler:

Non-alkolik yağlı karaciğer hastalığı, nesfatin-1, portal inflamasyon, fibrozis, obezite

Non-alcoholic Fatty Liver Disease and Its Association with Serum Nesfatin- 1

Aim: Nesfatin -1 is a novel peptide which is defined as satiety peptide with an anorexigenic action. Studies have shown its association with metabolic syndrome and insulin resistance. With this study, we sought to establish the association between clinicopathologic characteristics of patients with biopsy-diagnosed non-alcoholic fatty liver disease (NAFLD) and Nesfatin-1. Materials and Methods: Serum Nesfatin-1 levels were measured using the enzyme-linked immunosorbent assay in 59 patients with histologically diagnosed NAFLD and a control group comprising 32 healthy subjects. Results: Serum Nesfatin-1 level did not significantly differ between patients with NAFLD and control group (p<0.170). Simple correlation analysis showed that nesfatin-1 levels decreased as body mass index increased (p=0.043) and nesfatin-1 values increased in proportion to elevations in AST (p=0.05). A multiple regression model constructed for assessment showed that while portal inflammation (B=10.767, p=0.007), body mass index score (B=-0.510, p<0.001) and HDL cholesterol (B=-0.208, p<0.001) had a negative association with nesfatin-1, age (B=0.120, p=0.031), sex (lower levels among males versus females) (B=-40.897, p<0.001), systolic blood pressure (B=0.063, P=0.050) and AST (B=0.033, p=0.019) had a positive and linear significant association with nesfatin-1. Conclusion: In conclusion, the findings point out that serum nesfatin-1 level may be an independent predictor of portal inflammation in NAFLD.

Keywords:

NAFLD, ; nesfatin-1, portal inflammation, fibrosis, obesity,

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