Özgür EKİNCİ, Metin LEBLEBİCİ, Mehmet ACAR, Cem Ilgın EROL, Orhan ALİMOĞLU

Gastrointestinal Stromal Tümör Rekürrensinde Risk Faktörleri

Amaç: Gastrointestinal stromal tümörler (GIST), gastrointestinal sistemin en yaygın mezenkimal neoplazilerindendir. Temiz sınırlı cerrahi rezeksiyon GIST tedavisinin en önemli basamaklarından birini oluşturmaktadır. Bu araştırmada primer amaç GIST tanısıyla ameliyat ettiğimiz hastalarda rekürrens için risk faktörlerini değerlendirmek, sekonder amaç ise hangi faktölerin sağkalıma etki ettiğini ortaya koymaktır.

Anahtar Kelimeler:

Gastrointestinalstromal tümör, gastrointestinal sistem, mezenkimal kanser, cerrahi

Risk Factors of Gastrointestinal Stromal Tumor Recurrence

Aim: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasia of gastrointestinal system. Radical surgery with negative margin is the most important step for treatment of GIST. The primary aim of this study was to evaluate the risk factors for recurrence in patients who underwent surgery with diagnosis of GIST. Secondary aim was to reveal the factors that affect survival.

Keywords:

Gastrointestinal stromal tumor, gastrointestinal system, mesenchymal cancer, surgery,

PDF

___

Levy AD, Remotti HE, Thompson WM, Sobin LH, Miettinen M. Gastrointestinal stromal tumors: radiologic features with pathologic correlation. Radiographics 2003; 23: 283- 304.
Domansk HA, Walther CS. Gastrointestinal Stromal Tumor. Monogr Clin Cytol. 2017;22:89-91
Caterino S, Lorenzon L, Petrucciani N, et al. Gastrointestinal stromal tumors: correlation between symptoms at presentation, tumor location and prognostic factors in 47 consecutive patients. World J Surg Oncol. 2011;9:13.
Miettinen M, Sarlomo-Rikala M, Lasota J. Gastrointestinal stromal tumors: recent advances in understanding of their biology. Hum Pathol 1999; 30: 1213-20
Akahoshi K, Oya M, Koga T, Shiratsuchi Y. Current clinical management of gastrointestinal stromal tumor. World J Gastroenterol. 2018;24(26):2806‐2817.
Nishida T, Blay JY, Hirota S, Kitagawa Y, Kang YK. The standard diagnosis, treatment, and follow-up of gastrointestinal stromal tumors based on guidelines. Gastric Cancer. 2016;19(1):3‐14.
Lim KT, Tan KY. Current research and treatment for gastrointestinal stromal tumors. World J Gastroenterol. 2017;23(27):4856‐4866.
Landi B, Blay JY, Bonvalot S, et al. Gastrointestinal stromal tumours (GISTs): French Intergroup Clinical Practice Guidelines for diagnosis, treatments and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO). Dig Liver Dis. 2019;51(9):1223‐1231.
Eriksson M, Reichardt P, Sundby Hall K, et al. Needle biopsy through the abdominal wall for the diagnosis of gastrointestinal stromal tumour - Does it increase the risk for tumour cell seeding and recurrence?. Eur J Cancer. 2016;59:128‐133.
Kim GH, Choi KD, Gong CS, et al. Comparison of the treatment outcomes of endoscopic and surgical resection of GI stromal tumors in the stomach: a propensity score-matched case-control study. Gastrointest Endosc. 2020;91(3):527‐536.
Casali PG, Abecassis N, Aro HT, et al. Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2018;29(Suppl 4):iv267.
Joensuu H, Vehtari A, Riihimäki J, et al. Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts. Lancet Oncol. 2012;13(3):265‐274.
Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol. 2002;33: 459–65.
DeMatteo RP, Lewis JJ, Leung D, et al: Two hundred gastrointestinal stromal tumors: Recurrence patterns and prognostic factors for survival. Ann Surg 231:51-58, 2000
Mengshi Yi, MD,Lin Xia, MD,Yan Zhou, MD, Xiaoting Wu, MD, Wen Zhuang, MD, Yi Chen, MD, Rui Zhao, MD, Qianyi Wan, MD, Liang Du, MD, Yong Zhou, MD. Prognostic value of tumor necrosis in gastrointestinal stromal tumor. Medicine (Baltimore). 2019 Apr; 98(17): e15338
Segales-Rojas P, Lino-Silva LS, Aguilar-Cruz E, Salcedo-Hernández RA. Association of ki67 Index with Recurrence in Gastrointestinal Stromal Tumors. J Gastrointest Cancer. 2018 Dec;49(4):543-547.
Atak T, Eren T, Burcu B, Sagiroglu J, Ozemir İA, Alimoglu O. Gastrointestinal Stromal Tumors: Retrospective Analysis of 21 Cases. Haydarpasa Numune Med J 2019;59(2):157–161
Mazer L, Worth P, Visser B. Minimally invasive options for gastrointestinal stromal tumors of the stomach [published online ahead of print, 2020 Mar 27]. Surg Endosc. 2020;10.1007/s00464-020-07510-x.