Jaya KEERTHANA, Thangavelu LAKSHMİ, Roy ANİTHA, S. Rajesh KUMAR, S. RAGHUNANDHAKUMAR, R.V. GEETHA

Estimation of Iron and Ferritin Levels in Oral Submucousfibrosis (OSMF) Patients

Oral submucous fibrosis, with mucosal sensitivity to irritants such as areca nuts and chilly items due to chronic iron deficiency, is a form of sideropenic dysphagia. Serum iron is used for nutritional evaluation as a biochemical measure and serves as a predictor for the progression of the disease as there is a correlation between the quality of serum iron and oral carcinogenesis. Early diagnosis and prognosis can also be carried out by the assessment of biochemical parameters. The purpose of the research was to test OSMF patients with serum iron and ferritin. After prior consent, 50 participants were included in the study. They've been split into two classes. The research group consisted of 25 average, healthy individuals and a further 25 OSMF patients. 5 ml of blood was collected using a centrifuge and the serum was separated. Using the ERBA CHEM 5 plus analyser, serum iron was estimated using the Ferrozine/MgCO3 method and Ferritin by the Immunoturbidimetric Latex Assay methodIt was found that serum iron and serum ferritin levels decreased significantly compared to control levels in OSMF patients. In OSMF patients, serum iron was 84.29 ±19.3524.6419.35 compared to control 121.21 ± 19.35 and serum ferritin was77.14 ± 17.26 and 134.69 ±31.3 respectively. The current study concludes that serum iron and ferritin levels in OSMF patients are decreased relative to control levels that can be used to distinguish such patients as an indicator.

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