Karaciğer Nakilli Bir Hastada İlaç İlişkili Aneminin Muhtemel Sebebi Olarak Tenofovir Disoproksil Fumarat

Tenofovir disoproxil fumarat kronik hepatit B tedavisinde kullanılan etki gücü yüksek yan etki potansiyeli düşük bir antiviral ajandır. Hepatit B’ye bağlı karaciğer sirozu nedeniyle karaciğer nakli yapılan hastalarda nakil sonrası rekürrensin önlenmesi amacıyla da kullanılmaktadır. Bu yazıda hepatit B proflaksisi için adefovir kullanmaktayken tedavisi tenofovir disoproksil fumarata değiştirilen ve sonrasında ilaç ilişkili hemolitik anemi geliştiği düşünülen karaciğer nakilli bir hasta bildirilmiştir

Anahtar Kelimeler:

Tenofovir disoproksil fumarat, Anemi, Kronik hepatit B, Karaciğer nakli

Tenofovir Disoproxil Fumarate as a Possible Agent of Drug-Induced Anemia in a Liver Transplant Patient

Tenofovir disoproxil fumarate is an antiviral agent with high potency and low side effect profile. It is also used for the prevention of recurrence in patients undergoing liver transplantation due to liver cirrhosis secondary to hepatitis B. In this article, we report a patient with liver transplantation who had been treated with adefovir for hepatitis B prophylaxis and whose treatment was changed to tenofovir disoproxil fumarate, and was then thought to develop drug-induced hemolytic anemia

Keywords:

Tenofovir disoproxil fumarate, Anemia, Chronic hepatitis B, Liver transplantation,

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