Azar ABIYEV, Harun KÜÇÜK, Beyza Hilal KINDAN, Kübra ÇALIŞKAN GÜNEŞ, Ayşe DURSUN, İbrahim DOĞAN, Tarkan KARAKAN

Whipple hastalığı ve multiple myelom birlikteliği: nadir bir olgu sunumu

Whipple hastalığı, ağırlıklı olarak gastrointesinal sistemi etkilemekle birlikte birçok sistemi tutabilen, nadir görülen enfeksiyöz bir hastalıktır. Whipple hastalığının immünsupresyon ile ilişkili olduğu düşünülse de, bu konuda net bir bilgi yoktur. Aynı zamanda hematolojik malignitelerde Whipple hastalığının görüldüğüne dair herhangi bir vaka rapor edilmemiştir. Whipple hastalığı ve multiple myelomun birlikte görüldüğü nadir bir vakadan bahsedeceğiz.

Anahtar Kelimeler:

Malabsorbsiyon sendromu, Whipple hastalığı, multiple myelom

Coexistence of Whipple's disease and multiple myeloma: A rare case report

Whipple's disease is a rare infectious disease that predominantly affects the gastrointestinal tract, but can involve many systems. Although Whipple's disease is thought to be associated with immunosuppression, there is no clear information on this subject. Also, no cases of Whipple's disease have been reported in hematological malignancies. We will talk about a rare case where Whipple's disease and multiple myeloma are seen together.

Keywords:

Malabsorption syndrome, Whipple disease, multiple myeloma,

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1. Fenollar F, Puéchal X, Raoult D. Whipple's disease. N Engl J Med 2007;356:55-66.
2. Antunes C, Singhal M. Whipple Disease. [Updated 2021 Jul 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441937/
3. Mark Feldman, Lawrence S. Friedman, Lawrence J. Brandt. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management 11th edition. Philadelphia:Saunders, 2020. pp 1769-1778.
4. Lopes A, Santos AF, Alvarenga MJ, Mello E Silva A. Whipple's disease: a rare case of malabsorption. BMJ Case Rep. 2018;2018:bcr2017222955.
5. Biagi F, Balduzzi D, Delvino P, et al. Prevalence of Whipple’s disease in north-western Italy. Eur J Clin Microbiol Infect Dis 2015;34:1347-8.
6. Melas N, Amin R, Gyllemark P, et al. Whipple's disease: the great masquerader-a high level of suspicion is the key to diagnosis. BMC Gastroenterol 2021;21:128.
7. Gruner U, Goesch P, Donner A, Peters U. Morbus Whipple und Non-Hodgkin-Lymphom [Whipple disease and non-Hodgkin lymphoma]. Z Gastroenterol 2001;39:305-9.