Hepatosellüler kanserin humerus metastazı: Nadir bir olgu sunumu

Hepatosellüler karsinom karaciğerin en sık görülen primer tümörüdür. Hepatosellüler karsinom sıklıkla kemiklere metastaz yapar. Hepatosellüler karsinom prognozu erken tanı ve tedavi modalitelerindeki ilerleme nedeniyle giderek daha iyi hale gelmektedir. Sağkalım arttıkça kemik metastazları ile daha çok karşılaşılmaktadır. Bununla birlikte humerus metastazı çok nadirdir. Kemik metastazları semptomlar ve patolojik fraktürlerle sonuçlanabilir. Hepatosellüler karsinomun kemik metastazı hastanın yaşam kalitesini kötüleştirebilir. Erken tanı ve uygun tedavi çok önemlidir. Burada hepatosellüler karsinomun humerus metastazı olan ve rezeksiyon ve endoprotez ile tedavi edilen nadir bir olguyu sunacağız.

Humerus metastasis of hepatocellular carcinoma: A rare case report

Hepatocellular carcinoma is the most common primary liver tumor. Hepatocellular carcinoma usually makes metastasis to bones. Prognosis of bone metastasis of hepatocellular carcinoma is becoming better with early diagnosis and improvements in treatment modalities. As survival increases, bone metastasis is faced more. However, humerus metastasis is very rare. Bone metastasis may result in symptoms and pathologic fractures. Hepatocellular carcinoma metastasis of bone worsens patients’ quality of life. Early diagnosis and proper treatment are very important. Herein we report a rare case with humerus metastasis of hepatocellular carcinoma which is treated with resection and endoprosthesis.

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  • 1. Hu C, Yang J, Huang Z, et al. Diagnostic and prognostic nomograms for bone metastasis in hepatocellular carcinoma. BMC Cancer 2020;20:494.
  • 2. Guo X, Xu Y, Wang X, et al. Advanced hepatocellular carcinoma with bone metastases: Prevalence, associated factors, and survival estimation. Med Sci Monit 2019;25:1105-12.
  • 3. Uchino K, Tateishi R, Shiina S, et al. Hepatocellular carcinoma with extrahepatic metastasis: clinical features and prognostic factors. Cancer 2011;117:4475-83.
  • 4. Hirai T, Shinoda Y, Tateishi R, et al. Early detection of bone metastases of hepatocellular carcinoma reduces bone fracture and paralysis. Jpn J Clin Oncol 2019;49:529-36.
  • 5. Zhang L, Niu H, Ma J, et al. The molecular mechanism of LncRNA34a-mediated regulation of bone metastasis in hepatocellular carcinoma. Mol Cancer 2019;18:120.
  • 6. Pinnamaneni S, Damron TA. Proximal humerus reconstruction in orthopedic oncology. J Cancer Metastasis Treat 2021;7:7.
  • 7. Chen D, Li Z, Song Q, et al. Clinicopathological features and differential diagnosis of hepatocellular carcinoma in extrahepatic metastases. Medicine (Baltimore) 2018;97:e13356.
  • 8. Zhan H, Zhao X, Lu Z, Yao Y, Zhang X. Correlation and survival analysis of distant metastasis site and prognosis in patients with hepatocellular carcinoma. Front Oncol 2021;11:652768.
  • 9. European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver. EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma. J Hepatol 2018;69:182-236.
  • 10. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68:394-424.
  • 11. Uka K, Aikata H, Takaki S, et al. Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma. World J Gastroenterol 2007;13:414-20.
  • 12. Hansch A, Neumann R, Pfeil A, et al. Embolization of an unusual metastatic site of hepatocellular carcinoma in the humerus. World J Gastroenterol 2009;15:2280-2.
  • 13. Bukhari S, Ward K, Styler M. Hepatocellular carcinoma: First manifestation as solitary humeral bone metastasis. Case Rep Oncol Med 2020;2020:8254236.
  • 14. Piccioli A, Maccauro G, Rossi B, et al. Surgical treatment of pathologic fractures of humerus. Injury 2010;41:1112-6.
  • 15. Chen L, Wang Z, Song S, et al. The efficacy of radiotherapy in the treatment of hepatocellular carcinoma with distant organ metastasis. J Oncol 2021;2021:5190611.
  • 16. Zhang Y, Xu Y, Ma W, et al. The homogeneity and heterogeneity of occurrence, characteristics, and prognosis in hepatocellular carcinoma patients with synchronous and metachronous bone metastasis. J Cancer 2022;13:393-400.
Akademik Gastroenteroloji Dergisi-Cover
  • ISSN: 1303-6629
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 2002
  • Yayıncı: Jülide Gülay Özler