Aysu YETİŞ, Asuman ÇELİKBİLEK, Aysel KAYA TEKEŞİN, Orhan YAĞIZ

Hemorajik İnmeli Hastalarda Homosistein Düzeyleri

Amaç: Biriken veriler, artan homosistein iskemik inme için bir risk faktörü olduğunu göstermiştir. Ancak, yükselmiş homosistein seviyesinin, inme hastalarının yaklaşık beşte birini oluşturan hemorajik inme için de bir risk faktörü olup olmadığı belirsizdir. Amacımız, olası bir bağlantıyı araştırmak için hemorajik inmeli hastalarda plazma homosistein düzeylerini ölçmekti. Araçlar ve Yöntem: Çalışmaya otuz iskemik inmeli hasta, otuz hemorajik inmeli hasta ve otuz sağlıklı gönüllü aldık. Bütün hastalar, konvansiyonel risk faktörleri ve homosistein, vitamin B12 ve folik asit düzeyleri açısından incelendi. Bulgular: Hipertansiyon, hem iskemik inme hem de hemorajik inme hastalarında sağlıklı katılımcılara göre daha yüksekti (p=0.029). Homosistein düzeyleri, hem iskemik inme hem de hemorajik inme gruplarında kontrol grubuyla karşılaştırıldığında istatistiki olarak yüksek bulundu (p=0.001) ve aralarında istatistiki olarak anlamlı bir farklılık yoktu (p>0.05). B12 vitamini düzeyleri hem iskemik inme hem de hemorajik inme hastalarında kontrollere göre anlamlı olarak daha düşüktü (p=0.001) ve aralarında istatistiksel olarak fark yoktu (p>0.05). Folik asit seviyeleri açısından gruplar arasında istatistiki olarak anlamlı bir farklılık bulunmadı (p>0.05). Homosistein, vitamin B12 ve folik asit düzeyleri arasında korelasyon bulunmadı (p>0.05). Sonuç: Çalışmamız, hemorajik inme hastalarında homosistein düzeylerinin yüksek olduğunu göstermiştir. Hemorajik inmede homosisteinin rolünü netleştirmek için daha büyük kohortlara ihtiyaç vardır.

Anahtar Kelimeler:

hemorajik inme, homosistein, folik asit, B12 vitamini

Homocysteine Levels in Patients with Hemorrhagic Stroke

Purpose: Accumulating data demonstrated that raised homocysteine is a risk factor for ischemic stroke. However, it remains unclear whether high homocysteine level is also a risk factor for hemorrhagic stroke, which accounts for about one-fifth of stroke patients. Our aim was to measure the plasma homocysteine levels in patients with hemorrhagic stroke to explore a possible link. Materıals and Methods: We included thirty patients with ischemic stroke, thirty patients with hemorrhagic stroke, and thirty healthy volunteers. All participants were examined for traditional risk factors and levels of folic acid, homocysteine, and vitamin B12. Results: Hypertension was higher in both ischemic stroke and hemorrhagic stroke patients than in healthy participants (p=0.029). Homocysteine levels were significantly higher in both ischemic stroke and hemorrhagic stroke groups than in the control group (p=0.001), with no statistically difference between each other (p>0.05). Vitamin B12 levels were significantly lower in both ischemic stroke and hemorrhagic stroke patients than in the controls (p=0.001), with no statistically difference between each other (p>0.05). Folic acid levels did not significantly differ between the groups (p>0.05). We did not find correlation between homocysteine, vitamin B12 and folic acid levels (p>0.05). Conclusion: Our study indicated that the homocysteine levels were high in patients with hemorrhagic stroke. Larger cohorts are needed to clarify the role of homocysteine in hemorrhagic stroke.

Keywords:

hemorragic stroke, homocysteine, vitamin B12, folic acid,

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