Periprostatik lokal anestezinin tekrarlayan prostat biyopsisi üzerine etkisinin retrospektif olarak değerlendirilmesi
Amaç: Çalışmamızda daha önce prostat biyopsisi deneyimi yaşayan ve yaşamayan hastalarda %25 lidokain ile yapılan periprostatik sinir bloğunun ağrı palyasyonu açısından etkisi retrospektif olarak araştırılması amaçlanmıştır.Gereç ve Yöntem: Çalışmamıza genişletilmiş (12 kor) ve satürasyon (22 kor) biyopsisi yapılan hastalar alındı. Hastalar, genişletilmiş biyopsi yapılan hastalar (Grup I), satürasyon biyopsisi yapılan hastalar (Grup II) ve ilk defa biyopsi yapılacak kontrol grubu hastalar (Grup III) olmak üzere 3 gruba ayrıldı. Tüm hastalara 10cc %2 lidokain transrektal ultrasonografi (TRUSG) eşliğinde prostatın her iki seminal veziküler bileşkesine ve apeksine uygulandı. İşlem sonrası hastaların ağrı düzeyleri 10 cm'lik lineer Vizüel Analog Skala (VAS) aracılığıyla değerlendirildi.Bulgular: İşlem sonrası grupların VAS değerleri sırasıyla 2.96±1.06, 3.2±1.47 ve 2.93± 0.94 olarak bulundu (p>0.05). Sayısal olarak en yüksek ağrı skoru satürasyon grubu hastalarında bulunurken en düşük ağrı düzeyi genişletilmiş biyopsi yapılan grupta bulundu. Ancak gruplar arasında istatistiksel olarak bir fark izlenmedi.Sonuç: Çalışmamızda %2 lidokain kullanılarak yapılan periprostatik lokal anestezi enjeksiyonu tekrarlayan prostat biyopsilerinde etkili bir lokal anestezi sağladığı görülmüştür. Ayrıca tekrarlayan prostat biyopsilerinde alınan kor sayısı arttıkça ağrı düzeyinin arttığı bulunmuştur ancak bu durum istatistiksel olarak ortaya konulamamıştır
Retrospective evaluation of the effects of periprostatic local anesthesia on recurrent prostate biopsy
Objectives: The aim of the study was investigate the pain palliation effect of 2% dose of lidocaine on the periprostatic nerve block in prostate biopsy patients.Methods: Extended (12 cores) and saturation (22 cores) biopsy patients were included. The patients were separated into three groups: extended biopsy patients (Group I), saturation biopsy patients (Group II), and control group patients undergoing a biopsy procedure for the first time (Group III). All patients received 2% lidocaine (10 mL) on both the seminal vesicular junction and apex of the prostate with transrectal ultrasonography guidance. Following the procedure, the pain levels of patients were assessed using a 10-cm linear Visual Analog Scale (VAS).Results: Following the procedure, the VAS values of each group were 2.96±1.06, 3.2±1.47, and 2.93±0.94, respectively (p>0.05). While the highest pain score was seen in the saturation group patients (II), the lowest pain level was seen in the control biopsy group (III). However, no statistical di erence was observed among the groups.Conclusion: Herein, we observed that a local injection using 2% lidocaine was effective as local anesthetic in recurrent prostate biopsies. In addition, it was found that the pain level increases as the number of cores taken in recurrent prostate biopsies increases; however, this has not been established statistically
___
- 1. Coley CM, Barry MJ, Fleming C, Wasson JH, Fahs MC, Oesterling JE. Should Medicare provide reimbursement for prostate-specific antigen testing for early detection of prostate cancer? Part II: Early detection strategies. Urology 1995;46(2):125–41.
- 2. Nash PA, Bruce JE, Indudhara R, Shinohara K. Transrectal ultrasound guided prostatic nerve blockade eases systematic needle biopsy of the prostate. J Urol 1996;155(2):607–9.
- 3. Aus G, Hermansson CG, Hugosson J, Pedersen KV. Transrectal ultrasound examination of the prostate: complications and acceptance by patients. Br J Urol 1993;71(4):457–9.
- 4. Maccagnano C, Scattoni V, Roscigno M, Raber M, Angiolilli D, Montorsi F, et al. Anaesthesia in transrectal prostate biopsy: which is the most effective technique? Urol Int 2011;87(1):1–13.
- 5. Heidenreich A, Bastian PJ, Bellmunt J, Bolla M, Joniau S, van der Kwast T, et al; European Association of Urology. EAU guidelines on prostate cancer. part 1: screening, diagnosis, and local treatment with curative intent-update 2013. Eur Urol 2014;65(1):124–37.
- 6. Máderová E, Kestnerová V, Cervenka J, Puceková C. Prevalence of nosocomial infections in selected hospitals. J Hyg Epidemiol Microbiol Immunol 1987;31(4):365–74.
- 7. Epstein JI, Herawi M. Prostate needle biopsies containing prostatic intraepithelial neoplasia or atypical foci suspicious for carcinoma: implications for patient care. J Urol 2006;175(3 Pt 1):820–34.
- 8. Shiraishi K, Oka S, Matsuyama H. Predictive Factors for Sperm Recovery after Varicocelectomy in Men with Nonobstructive Azoospermia. J Urol 2017;197(2):485–90.
- 9. Kronz JD, Shaikh AA, Epstein JI. High-grade prostatic intraepithelial neoplasia with adjacent small atypical glands on prostate biopsy. Hum Pathol 2001;32(4):389–95.
- 10. Guo CC, Epstein JI. Intraductal carcinoma of the prostate on needle biopsy: Histologic features and clinical significance. Mod Pathol 2006;19(12):1528–35.
- 11. Donovan J, Hamdy F, Neal D, Peters T, Oliver S, Brindle L, et al; ProtecT Study Group. Prostate Testing for Cancer and Treatment (ProtecT) feasibility study. Health Technol Assess 2003;7(14):1–88.
- 12. Walz J, Graefen M, Chun FK, Erbersdobler A, Haese A, Steuber T, et al. High incidence of prostate cancer detected by saturation biopsy after previous negative biopsy series. Eur Urol 2006;50(3):498–505.
- 13. Ozden E, Bostanci Y, Yakupoglu KY, Akdeniz E, Yilmaz AF, Tulek N, et al. Incidence of acute prostatitis caused by extended-spectrum beta-lactamase-producing Escherichia coli after transrectal prostate biopsy. Urology 2009;74(1):119–23.
- 14. Tsuji FH, Chambó RC, Agostinho AD, Trindade Filho JC, de Jesus CM. Sedoanalgesia with midazolam and fentanyl citrate controls probe pain during prostate biopsy by transrectal ultrasound. Korean J Urol 2014;55(2):106–11.
- 15. Capitanio U, Pfister D, Emberton M. Repeat Prostate Biopsy: Rationale, Indications, and Strategies. Eur Urol Focus 2015;1(2):127–36.
- 16. Maccagnano C, Gallina A, Roscigno M, Raber M, Capitanio U, Saccà A, et al. Prostate saturation biopsy following a first negative biopsy: state of the art. Urol Int 2012;89(2):126–35.
- 17. Tüfek I, Akpinar H, Atuğ F, Öbek C, Esen HE, Keskin MS, et al. The impact of local anesthetic volume and concentration on pain during prostate biopsy: a prospective randomized trial. J Endourol 2012;26(2):174–7.
- 18. Moussa AS, El-Shafei A, Diaz E, Gao T, Zaytoun OM, Fareed K, et al. Identification of the variables associated with pain during transrectal ultrasonography-guided prostate biopsy in the era of periprostatic nerve block: the role of transrectal probe configuration. BJU Int 2013;111(8):1281–6.
- 19. Djavan B, Waldert M, Zlotta A, Dobronski P, Seitz C, Remzi M, et al. Safety and morbidity of first and repeat transrectal ultrasound guided prostate needle biopsies: results of a prospective European prostate cancer detection study. J Urol 2001;166(3):856–60.
- 20. Zisman A, Leibovici D, Kleinmann J, Siegel YI, Lindner A. The impact of prostate biopsy on patient well-being: a prospective study of pain, anxiety and erectile dysfunction. J Urol 2001;165(2):445–54.