AHMET OĞUZHAN ÖZEN, Hülya ERCAN SARIÇOBAN, Nilgün MUTLU, Mehmet Reha CENGİZLİER

Çocukluk çağında migren tipi başağrısı ile inek sütü ve yumurta akı allerjisi arasındaki ilişki

Giriş ve amaç: Migren tipi başağrısı çok sık karşılaşılan bir baş ağrısı tipidir. Migren ile alerjik hastalıkların yaygın olarak beraber görülmesi migren patofizyolojisinde alerjik mekanizmaların rol oynayabileceğini düşündürmüştür. Bu çalışmada çocukluk çağında besin alerjilerinin önemli bir kısmından sorumlu olan süt ve yumurta akı alerjilerinin migren ile ilişkisini araştırmayı amaçladık. Materyal-Metod: Daha önce yapılan okul çalışmasında migren tipi başağrısı tespit edilen 39 öğrenci ile başağrısı tariflemeyen 167 çocuk çalışmaya alındı. Çocukların serum örneklerinden süt ve yumurta akı-spesifik IgE düzeyleri ölçüldü. Bulgular: Toplam 4 çocukta süt spesifik IgE pozitif bulunurken 2 çocukta yumurta akı-spesifik IgE pozitif bulundu. Her iki besin spesifisik IgE pozitifliği ile migren arasında bir ilişki saptanmadı. Ancak yumurta akı-spesifik IgE düzeyleri migren tipi başağrısı olan çocuklarda anlamlı olarak daha yüksek bulundu (p=0.008). Sonuç: Çocukluk çağı migreninde süt ve yumurta allerjilerinin rolü gösterilememiştir. Ancak migren tipi başağrısı olan çocuklarda yumurta akı-spesifik IgE değerlerinin yüksekliği migren ile besin alerjilerinin patogenezinde ortak mekanizmaların rol oynadığına işaret edebilir.

Relationship between migraine type headache in childhood with cow’s milk allergy and egg-white allergy

Background and aim: Migraine is a very common headache disorder. Due to the co-occurrence of migraine and allergic disorders allergic mechanisms have been thought to play role in migraine pathophysiology. This study aimed to investigate the association between cow's milk allergy and egg-white allergy with migraine type headache of childhood. Materials and methods: We included 39 children with migraine type headaches and 167 children with no headaches who had been previously evaluated in a school screening study program. Egg-white and cow's milk specific IgE levels were measured for all involved subjects. Results: Specific IgE levels were positive for cow's milk in 4 children and for egg-white in 2 children, respectively. There was not detected meaningful relationship between food allergies and migraine. However, specific IgE levels for egg-white were significantly higher in migraineurs (p=0.008). Conclusion: Childhood migraine does not appear to be associated with cow's milk or egg-white allergy. However, the elevation of egg-white specific IgE levels in migraine type headache may signify the possible presence of shared pathogenetic pathways in the development of migraine and food allergies.

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