$Zn^{2+}$ İyonları ile Çapraz Bağlı Sodyum Karboksimetil Selüloz KürelerdenFlurbiprofenin Kontrollü Salımı

Çalışmada, steroit olmayan anti-inflamatuar ilaç olan flurbiprofeni (FBP) kapsüllemek için sodyum karboksimetil selüloz (NaCMC) küreler $Zn^{2+}$ iyonları ile çapraz bağlanarak elde edildi. Elde edilen küreler Fourier transform infrared (FTIR) spektroskopisi ve diferansiyel taramalı kalorimetri (DSC) ile karakterize edildi ve çapları optik mikroskop kullanılarak ölçüldü. Ayrıca, kürelerin denge şişme dereceleri, tutuklama değerleri, küre verim değerleri ve salım profilleri değerlendirildi. Küre verimi, tutuklama verimi ve FBP salımı üzerine NaCMC derişiminin, FBP yüklemesinin ve pH’nın etkisi incelendi. Flurbiprofenin kürelerden salımı pH 1.2 ortamında çok az iken, pH 7.4 bağırsak ortamında ise kontrollü bir şekilde gerçekleşti. NaCMC derişimi ve FBP yüklemesi arttıkça, kürelerden FBP salımı azaldı ve en yüksek ilaç salımı, NaCMC derişimi % 2 ve ilaç yüklemesi % 10 olan kürelerde gözlendi. Salım kinetikleri çoğunlukla Durum II olarak tanımlandı.

Controlled Release of Flurbiprofen from Sodium Carboxymethyl Cellulose Spheres Crosslinked with $Zn^{2+}$ Ions

In the study, sodium carboxymethyl cellulose (NaCMC) spheres were obtained by crosslinking $Zn^{2+}$ ionsto encapsulate flurbiprofen (FBP), non-steroid anti-inflammatory drug. The spheres obtained werecharacterized by Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry(DSC) and their diameters were measured using an optical microscope. In addition, equilibrium swellingdegrees, entrapment efficiencies, sphere yield values and release profiles of the spheres wereevaluated. The effects of NaCMC concentration, FBP loading and pH on sphere yield, entrapmentefficiency and FBP release were investigated. The release of flurbiprofen from the spheres was very lowin pH 1.2 environment, whereas the release occurred in a controlled manner in the pH 7.4 intestinalenvironment. As the NaCMC concentration and FBP loading increased, FBP release from the spheresdecreased and the highest drug release was observed in spheres with a NaCMC concentration of 2%and a drug loading of 10%. The release kinetics were mostly described as Case II.

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