Rapid Deswelling of PDMAEMA Hydrogel in Response to pH and Temperature Changes and Its Application in Controlled Drug Delivery

Bu çalışmada, poli(2-dimetilaminoetil metakrilat) (PDMAEMA) jeli, in situ polimerizasyon yöntemiyle sentezlenmiştir. Sentezlenen hidrojel, FTIR spektroskopisi ve taramalı elektron mikroskobu (SEM) ile karakterize edilmiştir. PDMAEMA jelinin, pH ve sıcaklığa bağlı şişme / büzülme davranışı incelenmiştir. Hidrojel pH 2'de en yüksek denge şişme oranına ulaşmıştır. Artan sıcaklık, polimerik zincirler arasında hidrofobik etkileşimlerin baskın hale gelmesi nedeniyle hidrojelin şişme oranında azalmaya yol açmıştır. Bundan başka hidrojelin sıcaklık ve pH duyarlı büzülme cevap hızının oldukça yüksek olduğu gözlenmiştir. İbuprofen ilacı model olarak kullanılarak PDMAEMA jelinin ilaç salım profili rapor edilmiştir.

PDMAEMA Hidrojelinin pH ve Sıcaklık Değişimine Karşı Hızlı Büzülme Davranışı ve Kontrollü İlaç Salımında Uygulaması

In this study, poly(2-dimethylamino)ethyl methacrylate (PDMAEMA) gels were prepared via in situ polymerization reaction. Synthesized hydrogel was characterized with FTIR spectroscopy and SEM. The pH- and temperature dependentswelling / deswelling behavior was investigated. The hydrogelshowed highest value of swelling at pH 2. The rising temperature led to a decrease in swelling ratio due to the fact that hydrophobic interactions between polymer segments become dominant. Furthermore, it was observed that PDMAEMA hydrogel exhibited rapid deswelling rate in response to temperature and pH. The drug release profile of PDMAEMA hydrogel has been reported by using Ibuprofen as a model drug.

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