Önder ALICI, Şule KÖKTEN, İbrahim KARATAŞ, Erdoğan GÜNEŞ

Antibakteriyel Özelliğe Sahip Aminoglioksimlerin Sentezi ve Özelliklerinin İncelenmesi

Bu çalışmada önce difenileterin kloroasetilklorür ile AlCl3 katalizörlüğündeki reaksiyonundan 4-kloroasetildifenileter sentezlenmiştir. Sonra bunun nitrosolama metoduyla isonitroso-4-asetildifenileteri ve hidroksilaminhidroklorür ile asidik ortamdaki reaksiyonundan 4-fenoksifenilkloroglioksimi elde edildi. Daha sonra bu anti-fenoksifenilkloroglioksimin 2-amino-4-feniltiyazol ve 2-fluorenamin ile reaksiyonundan orijinal olarak sübstitüe-aminogliksim türevleri sentezlendi. Elde edilen bileşiklerin yapıları FT-IR ve 1H-NMR teknikleri kullanılarak aydınlatıldı. Ayrıca sentezlenen iki başlangıç maddesi, sentezlenen sübstitüe-aminoglioksim türevleri ve iki amin bileşiğinin, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 15442, metisilin duyarlı Staphylococcus aureus ATCC 25923 (MSSA), Klebsiella pneumoniae ATCC 70603, Salmonella enteritidis ATCC 13076 ve Sarcina lutea ATCC 9341 suşlarına karşı anti-bakteriyel özellikleri araştırıldı.

Synthesis of Aminoglioximes with Antibacterial Properties and Investigation of Properties

In this study, firstly 4-chloroacetyldiphenylether was synthesized from the reaction of diphenylether with chloroacetylchloride at AlCl3 catalysis. Then, 4-phenoxyphenyl-chloroglyoxime was obtained from reaction of isonitroso-4-acetyldiphenylether and hydroxylamine hydrochloride. Subsequently, substituted-amino glyoxime derivatives were originally synthesized from the reaction of this phenoxyphenylchloroglyoxime with 2-amino-4-phenylthiazole and 2-fluorenamine. The structures of the obtained compounds were tried to be elucidated using FT-IR and 1H-NMR techniques. In addition, Anti-bacterial properties of two starting materials synthesized, substituted-aminoglioxime derivatives synthesized and two amine compounds were investigated against the strains of Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 15442, methicillin sensitive Staphylococcus aureus ATCC 25923 (MSSA), Klebsiella pneumoniae ATCC 70603, Salmonella enteritidis ATCC 13076 and Sarcina lutea ATCC 9341.

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