Temporomandibular Bozuklukların Tedavisinde Botulinum Toksinin Rolü

Temporomandibular bozukluk, temporomandibular eklem ve beraberindeki dokuların patolojik durumlarını karakterize etmek için ortak kullanılan bir terimdir. Temporomandibular bozuklukların arkasında yer alan patolojiler tam olarak açıklanmasa da bu bozukluk ile ilişkili semptomlar benzerdir ve en sık orofasiyal bölgede ağrı olarak kendini göstermektedir. Yapılan ön çalışmalarda, botulinum toksini temporomandibular bozukluklar olmak üzere çeşitli ağrı sendromlarını tedavi etmek için başarıyla kullanılmıştır. Bu derlemenin amacı; botulinum toksini hakkında bilgi vermek, temporomandibular bozukluklardaki uygulamalarını, etki mekanizmasını ve uygulama dozlarını anlatmaktır.

Anahtar Kelimeler:

Bruksizm, Orofasiyal, Trismus, Nörotoksin

The Role of Botulinum Toxin in the Treatment of Temporomandibular Disorders

Temporomandibular disorder is a collective term used to characterize a pathological group of conditions involving the temporomandibular joint and its contiguous tissues. Although the pathologies behind temporomandibular disorders have not been completely explained, the symptoms associated with these disorders are similar and are most commonly manifest as pain in the orofacial region. In preliminary studies, botulinum toxin has been used successfully to treat various pain syndromes, including temporomandibular disorders. The aim of this review is to give information about botulinum toxin, its application in temporomandibular disorders, mechanism of action and application dosage were also described.

Keywords:

Bruxism, Orofacial, Trismus, Neurotoxin,

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Schwartz M, Freund B. Treatment of Temporomandibular Disorders with Botulinum Toxin. Clin J Pain 2002;18:198–3.
Sipahi Calis A, Colakoglu Z, Gunbay S. The use of botulinum toxin-a in the treatment of muscular temporomandibular joint disorders. J Stomatol Oral Maxillofac Surg 2019; 120:322-25.
Erdil D, Farsiani H, Bagis N. Application of dental botox. Dent & Med J 2019;1:89-2.
Scott AB. Botulinum toxin injection of eye muscles to correct strabismus. Trans Am Ophthalmol Soc 1981;79:734-70.
Coskun U, Yılmaz Altıntas N. Orofasial Bölgede Botulinum Toksin Uygulamaları. Fırat University Medical Journal of Health Sciences 2016;30:43-9.
Ondo WG, Simmons JH, Shahid MH, Hashem V, Hunter C, Jankovic J. On a botulinumtoxin-A injections for sleep bruxism. Neurology 2018;90:559-64.
Tan EK, Jankovic J. Treating severe bruxism with botulinum toxin. J Am Dent Assoc 2000;131:211-6.
Kwon KH, Shin KS, Yeon SH, Kwon DG. Application of botulinum toxin in maxillofacial field: part I. Bruxism and square jaw. Maxillofac Plast Reconstr Surg 2019;41:1-13.
Lee KH. Oromandibular dystonia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;104:491-6.
Yu GLT, Rosales RL. Treatment of Oromandibular Dystonia using Botulinum Toxin Injections- Case Series and Illustrative Muscle Targeting. Basal Ganglia 2018;13:7-16.
Zhou JY, Wang D. An Update on Botulinum Toxin A Injections of Trigger Points for Myofascial Pain. Curr Pain Headache Rep 2014;18:386.
Gobel H, Heinze A, Reichel G, Hefter H, Benecke R. Efficacy and safety of a single botulinum type A toxin complex treatment (Dysport) for the relief of upper back myofascial pain syndrome: Results from a randomized double-blind placebo-controlled multicentre study. Pain 2006;125:82-8.
Sidebottom AJ, Patel AA, Amin J. Botulinum injection for the management of myofascial pain in the masticatory muscles. A prospective outcome study. Br J Oral Maxillofac Surg 2013;51:199-5.
Freund B, Schwartz M, Symington JM. Botulinum toxin: New treatment for temporomandibular disorders. Br J Oral Maxillofac Surg 2000;38:466-71.
Sharma NK, Singh AK, Pandey A, Verma V, Singh S. Natl J Maxillofac Surg 2015;6: 16-20.
Bhargava D. Temporomandibular Joint Disorders. Springer 2021;244.
Fedorowicz Z, Van Zuuren EJ, Schoones J. Botulinum toxin for masseter hypertrophy. Cochrane Syst Rev 2013;2013:CD007510.
Kim N, Park R, Park J. Botulinum Toxin Type A for the Treatment of Hypertrophy of the Masseter Muscle. Plast Reconstr Surg: 2010;125:1693-5.
Freund B, Rao A. Efficacy of Botulinum Toxin in Tension-Type Headaches: A Systematic Review of the Literature. Pain Practice 2019;19:541-51.
Freund BJ, Schwartz M. A focal dystonia model for subsets of chronic tension headache. Cephalalgia 2000;20:433.
Zwart JA, Bovim G, Sand T, Sjaastad O. Tension headache: botulinum toxin paralysis of temporal muscles. Headache 1994;34:458–62.
Veziroglu Senel F, Deniz K, Bayram B. Botulinum Toxin-A Applications in Maxillofacial Surgery. ADO Journal of Clinical Sciences 2009;3:300-5.
Nilesh K, Patil M. The Application of Botulinum Toxin in Oral and Maxillofacial Surgery. 1th ed. Newcastle upon tyne: Lady Stephenson Library; 2022. p.95.
Bakke M. Botulinum Toxin, a Drug with Potential Interest for Dentists. Toxins 2022;14: 667.