519116

Genetik Faktörlerin Diş Çürüğü Üzerine Etkisinin Değerlendirilmesi

Diş çürüklerinin enfeksiyöz ve multifaktöriyel bir hastalık olduğu bilinmektedir. Bireylerde diş çürüklerine yatkınlıkla ilişkili olduğu düşünülen bazı genetik faktörlerin varlığı uzun yıllar araştırılmıştır. Bu genetik temeller ailesel ve deneysel çalışmaların yanı sıra, monozigot ve dizigot ikizleri de kapsayan çalışmaları da içerir. Günümüze kadar diş çürüklerinin oluşumunda önemli rollere sahip muhtemel proteinler ve genler üzerinde çalışmalar yapılmıştır. Çalışılan genler arasında HLA genleri, mine formasyon genleri (örneğin AMELX geni) ve tükürük bileşenlerini oluşturan genler bulunmaktadır. Diş çürüklerinin artmasına veya azalmasına etkili olan genetik faktörlerin tanımlanması, diş hekimlerinin de daha etkili ve koruyucu tedaviler sunmalarına olanak sağlayacaktır.

Anahtar Kelimeler:

Diş çürüğü, Genetik, Polimorfizm

Evaluation of the Effect of Genetic Factors on Dental Caries

Dental caries are known as infectious and multifactorial disease. The existence of some genetic factors thought to be associated with the susceptibility to dental caries in individuals has been investigated for many years. These genetic bases include familial and experimental studies as well as studies involving monozygotic and dizygotic twins. Until today, studies have been carried out on possible proteins and genes those have important roles in the formation of dental caries. Genes which have studied, include HLA genes, enamel formation genes (eg the AMELX gene), and genes those make up salivary components. Identification of genetic factors that affects the increase or decrease of dental caries will allow dentists to offer more effective and preventive treatments.

Keywords:

Dental caries, Genetics, Polymorphism,

PDF

___

1. Ulucan K, Pul U, Akçay T. Diş çürüklerinin oluşumuna moleküler yaklaşım. Journal of Cell & Molecular Biology 2010;8:2.
2. Özcan S. Diş Çürüğünün Tanımı Etiyolojisi ve İlerlemesi. 2016.
3. Featherstone JD. Dental caries: a dynamic disease process. Aust Dent J 2008;53:286-91.
4. Zero DT. Dental caries process. Dent Clin North Am 1999;43:635-64.
5. Shuler CF. Inherited risks for susceptibility to dental caries. J Dent Educ 2001;65:1038-45.
6. Özata F, Kaya AD. Dental Caries and Genetics 2001;22:13-21.
7. Turhan B, Saka M. Herediter Fruktoz İntoleransında Beslenme 2016;20:253-7.
8. Leal SC, Lia EN, Amorim R, Dos Santos MV, de Araújo MC, de Medeiros RA, et al. Higher dental caries prevalence and its association with dietary habits and physical limitation in epidermolysis bullosa patients: A case control study. J Contemp Dent Pract 2016;17:211-6.
9. Telatar GY, Ermiş RB. Çürük Riski Ve Genetik. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 2019;29:350-6.
10. Lehner T, Lamb JR, Welsh KL, Batchelor RJ. Association between HLA-DR antigens and helper cell activity in the control of dental caries. Nature 1981;292:770-2.
11. de Vries RR, Zeylemaker P, van Palenstein Helderman WH, Huis in 't Veld JH. Lack of association between HLA-DR antigens and dental caries. Tissue Antigens 1985;25:173-4.
12. Suzuki N, Kurihara Y. Dental caries susceptibility in mice is closely linked to the H-2 region on chromosome 17. Caries Res 1998;32:262-5.
13. Mandel ID. Nature vs. Nurture in Deni Caries. J Am Dent Assoc 1994;125:1345-51.
14. Segura JJ, Jiménez-Rubio A. Talon cusp affecting permanent maxillary lateral incisors in 2 family members. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;88:90-2.
15. Bayram M, Seymen F. Diş Çürüğüne Genetik Yaklaşım/Genetic Approach to Dental Caries. Türkiye Klinikleri Diş Hekimliği Bilimleri Dergisi 2014;20:129.
16. Goldberg S. The dental arches of identical twins. Dent Cosmos 1930;72:869-81.
17. Werneck R, Mira M, Trevilatto P. A critical review: an overview of genetic influence on dental caries. Oral Dis 2010;16:613-23.
18. Boraas JC, Messer LB, Till MJ. A genetic contribution to dental caries, occlusion, and morphology as demonstrated by twins reared apart. J Dent Res 1988;67:1150-5.
19. Opal S, Garg S, Jain J, Walia I. Genetic factors affecting dental caries risk. Aust Dent J 2015;60:2-11.
20. Slayton R, Cooper M, Marazita M. Tuftelin, mutans streptococci, and dental caries susceptibility. J Dent Res 2005;84:711-4.
21. Patir A, Seymen F, Yildirim M, Deeley K, Cooper ME, Marazita ML, et al. Enamel formation genes are associated with high caries experience in Turkish children. Caries Res 2008; 42:394-400.
22. Deeley K, Letra A, Rose EK, Brandon CA, Resick JM, Marazita ML, et al. Possible association of amelogenin to high caries experience in a Guatemalan-Mayan population. Caries Res 2008;42:8-13.
23. Kim JW, Hu JC, Lee JI, Moon SK, Kim YJ, Jang KT, et al. Mutational hot spot in the DSPP gene causing dentinogenesis imperfecta type II. Hum Genet 2005;116:186-91.
24. Yildiz G, Ermis RB, Calapoglu NS, Celik EU, Türel GY. Gene-environment interactions in the etiology of dental caries. J Dent Res 2016;95:74-9.
25. Peres RC, Camargo G, Mofatto LS, Cortellazzi KL, Santos MC, Nobre-dos-Santos M, et al. Association of polymorphisms in the carbonic anhydrase 6 gene with salivary buffer capacity, dental plaque pH, and caries index in children aged 7–9 years. Pharmacogenomics J 2010;10:114-9.
26. Culp DJ, Quivey RQ, Bowen WH, Fallon MA, Pearson SK, Faustoferri R. A mouse caries model and evaluation of Aqp5–/–knockout mice. Caries Res 2005;39:448-54.
27. Buczkowska-Radlińska J, Pol J, Szmidt M, Bińczak-Kuleta A. The influence of polymorphism of the MUC7 gene on the teeth and dental hygiene of students at a faculty of dentistry in Poland. Postepy Hig Med Dosw (Online) 2012;66:204-9.
28. Ozturk A, Famili P, Vieira AR. The antimicrobial peptide DEFB1 is associated with caries. J Dent Res 2010;89:631-6.
29. Renuka P, Pushpanjali K, Sangeetha R. Review on “Influence of host genes on dental caries”. J Dent Med Sci 2013;4:86-92.
30. Bretz WA, Corby PM, Melo MR, Coelho MQ, Costa SM, Robinson M, et al. Heritability estimates for dental caries and sucrose sweetness preference. Arch Oral Biol 2006;51:1156-60.
31. Lin BP. Caries experience in children with various genetic sensitivity levels to the bitter taste of 6-n-propylthiouracil (PROP): a pilot study. Pediatr Dent 2003;25:37-42.
32. Wright JT. Defining the contribution of genetics in the etiology of dental caries. J Dent Res 2010;89:1173-4.
33. Wendell S, Wang X, Brown M, Cooper ME, DeSensi RS, Weyant RJ, et al. Taste genes associated with dental caries. J Dent Res 2010;89:1198-202.
34. Fushan AA, Simons CT, Slack JP, Manichaikul A, Drayna D. Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose. Curr Biol 2009;19:1288-93.
35. Duffy VB, Davidson AC, Kidd JR, Kidd KK, Speed WC, Pakstis AJ, et al. Bitter receptor gene (TAS2R38), 6‐n‐propylthiouracil (PROP) bitterness and alcohol intake. Alcohol Clin Exp Res 2004;28:1629-37.
36. Achimastos A, Mavridis N, Hatjiotis J. Blood groups and dental caries experience in man. J Dent Res 1974;53:1300.
37. Green GE, Wilson RM, Freeman NC. Human blood types and dental caries experience. J Dent Res 1966;45:1818.