Aziz KILINÇ, Yasemin AKDEVELİOĞLU

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Vitaminler ve Non Alkolik Yağlı Karaciğer Hastalığı

Artan obezite prevalansına paralel olarak non alkolik yağlı karaciğer hastalığı birçok ülkede en yaygın karaciğer hastalığı haline gelmiştir. Non alkolik yağlı karaciğer hastalığı kardiyovasküler, hepatik, metabolik ve onkolojik sekellerinin yanı sıra karaciğer naklinin önde gelen nedeni haline geldiği için dünya çapında önemli bir morbidite ve mortalite nedenidir. Bu salgın ve sonuçları, dünyanın dört bir yanından uzmanları, hastalığın yönetimi ve tedavisi için etkili stratejiler belirlemeye yönlendirmiştir. Şu anda non alkolik yağlı karaciğer hastalığı için onaylanmış bir ilaç tedavisi yoktur. Bu nedenle diyet ve egzersiz gibi değiştirilebilir risk faktörleri hastalığın yönetimi ve tedavisinde köşe taşı olarak yerini korumaktadır. Vitaminler sağlıklı yaşam için hayati önem taşıyan mikro besin öğeleridir. Bazı çalışmalar yağlı karaciğer hastalığını vitamin eksiklikleri ile ilişkilendirse de bu ilişkilerin altında yatan mekanizma tam olarak aydınlatılamamıştır. Bu nedenle, bu derleme, vitaminlerin non alkolik yağlı karaciğer hastalığı patogenezindeki rolünü tartışmayı ve hastalık yönetiminde potansiyel faydalarını araştırmayı amaçlamaktadır.
Anahtar Kelimeler:

Non alkolik yağlı karaciğer hastalığı, Non alkolik yağlı karaciğer hastalığı, Vitaminler, Riboflavin, Askorbik asid

Vitamins and Non Alcoholic Fatty Liver Disease

In parallel with the increasing obesity prevalence, non-alcoholic fatty liver disease has become the most common liver disease in many countries. Non-alcoholic fatty liver disease is an important cause of morbidity and mortality worldwide, as it has become the leading cause of liver transplantation, as well as cardiovascular, hepatic, metabolic and oncological sequelae. This epidemic and its consequences have prompted experts from around the world to identify effective strategies for the management and treatment of the disease. There is currently no approved drug therapy for the treatment of non-alcoholic fatty liver disease. Therefore, modifiable risk factors such as diet and exercise remain as cornerstones in the management and treatment of the disease. Vitamins are micronutrients that are vital for a healthy life. Some studies have linked fatty liver disease with vitamin deficiencies. However, the mechanism underlying these relationships has not been fully elucidated. Therefore, this review aims to discuss the role of vitamins in the pathogenesis of non-alcoholic fatty liver disease and explore their potential benefits in disease management.
Keywords:

Non-alcoholic fatty liver disease, Vitamins, Riboflavin, Ascorbic acid,

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Adnan Menderes Üniversitesi Sağlık Bilimleri Fakültesi Dergisi-Cover
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 2017
  • Yayıncı: Aydın Adnan Menderes Üniversitesi
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