Objective: The aim of this study was to describe the characteristics of patientsundergoing upper extremity amputation (UEA) fordiabetic hand gangrene with aspecial focus on mortality and to determine the risk factors for thedevelopment of hand gangrenein diabetic patients.Methods: The medical records of patients who underwent lower extremity amputation (LEA) or UEA because of diabeticgangrene between January 2005 and December 2012 were retrospectively reviewed. Patients were then assigned to one of twogroups: the UEA group (n = 15, 9 male; mean age = 62 ± 12.4) and the LEA group (n = 280, 196 male; mean age = 64.6 ± 10.9). AKaplan-Meier analysis was performed to compare the five-year survival rates between the two groups. A multivariable logisticanalysis including demographic characteristics, laboratory data, and dialysis status was conducted to identify the risk factors fordiabetic hand gangrene.Results: The five-year mortality rate in the UEA group (86.7%, 13 of 15 patients) was significantly higher than that in the LEAgroup (51.8%, 145 of 280 patients, P < 0.001). Dialysis status was determined as a risk factor associated with the development ofdiabetic hand gangrene (OR, 4.05; 95% CI, 1.23-13.29; P = 0.021).Conclusion: Evidence from this study has revealed that that amputation for diabetichand gangrene is associated with a high rateof mortality. Among diabeticpatients, the five-year survival rate of patients who underwent amputation fordiabetic handgangrene was only 13.3%.Level of Evidence: Level IV, Prognostic Study
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1. WHO W. Global report on diabetes. World Health Organization 2016.
2. Stone AV, Xu NM, Patterson RW, Koman LA, Smith BP, Li Z. Five-year mortality for patients with end-stage renal disease who undergo upper extremity amputation. J Hand Surg Am. 2015;40(4):666-672. 10.1016/j.jhsa.2014.12.036
3. Gok U, Selek O, Selek A, Guduk A, Guner MC. Survival evaluation of the patients with diabetic major lower-extremity amputations. Musculoskelet Surg. 2016;100(2):145-148. 10.1007/s12306-016-0399-y
4. Huang YY, Lin CW, Yang HM, Hung SY, Chen IW. Survival and associated risk factors in patients with diabetes and amputations caused by infectious foot gangrene. J Foot Ankle Res. 2018;11(1): 10.1186/s13047-017-0243-0
5. Stern JR, Wong CK, Yerovinkina M, et al. A meta-analysis of long-term mortality and associated risk factors following lower extremity amputation. Ann Vasc Surg. 2017;42:322-327. 10.1016/j.avsg.2016.12.015
6. Lagaard SW, McElfresh EC, Premer RF. Gangrene of the upper extremity in diabetic patients. J Bone Joint Surg Am. 1989;71(2):257-264. 10.2106/00004623- 198971020-00013
7. Cebesoy O, Baltaci ET. Acute gangrene that developed in the fingers of the hand with arteriovenous fistule in a chronic hemodialysis patient. J Natl Med Assoc. 2006;98(10):1707-1709.
8. Stack AG, Bloembergen WE. Prevalence and clinical correlates of coronary artery disease among new dialysis patients in the United States: A cross-sectional study. J Am Soc Nephrol. 2001;12(7):1516-1523. 10.1681/ASN. V1271516
9. Koch M, Hollenbeck M, Trapp R, Kulas W, Grabensee B. Value of diabetes as an independent predictor of death in subjects with end-stage renal disease. Med Klin (Munich). 2006;101(12):933-937. 10.1007/s00063-006-1125-6
10. Hurton S, Embil JM, Reda A, et al. Upper extremity complications in patients with chronic renal failure receiving haemodialysis. J Ren Care. 2010;36(4):203- 211. 10.1111/j.1755-6686.2010.00197.x
11. Yeager RA, Moneta GL, Edwards JM, et al. Relationship of hemodialysis access to finger gangrene in patients with end-stage renal disease. J Vasc Surg. 2002;36 (2):245-249. 10.1067/mva.2002.125026
12. Tzamaloukas AH, Murata GH, Harford AM, et al. Hand gangrene in diabetic patients on chronic dialysis. ASAIO Trans. 1991;37(4):638-643.
13. Taylor LMJr., Moneta GL, Sexton GJ, Schuff RA, Porter JM. Prospective blinded study of the relationship between plasma homocysteine and progression of symptomatic peripheral arterial disease. J Vasc Surg. 1999;29(1):8-19. 10.1016/ S0741-5214(99)70345-9
14. Valentine RJ, Kaplan HS, Green R, Jacobsen DW, Myers SI, Clagett GP. Lipoprotein (a)homocysteine, and hypercoagulable states in young men with premature peripheral atherosclerosis: Aprospective controlled analysis. J Vasc Surg. 1996;23(1):53-61. 10.1016/S0741-5214(05)80035-7
15. Azar FM, Canale ST, Beaty JH. Campbell’s Operative Orthopaedics E -book.: Elsevier Health Sciences, 2016.
16. Wolfe SW, Pederson WC, Hotchkiss RN, Kozin SH, Cohen MS. Green’s Operative Hand Surgery. The Pediatric Hand E -book. Elsevier Health Sciences, 2010.