Bo XU, Run-lin XING, Li ZHANG, Zheng-quan HUANG, Nong-Shan ZHANG, Jun MAO

Effects of MMP-1 1G/2G polymorphism on osteoarthritis: A meta-analysis study

Objective: The aim of this meta-analysis was to clarify the role of Matrix metalloproteinase 1 (MMP-1) -1607 1G/2G (rs1799750) polymorphism on the osteoarthritis (OA) risk. Methods: Articles were selected by retrieving the Web of Science, Embase and Pubmed. The strength of the association between -1607 1G/2G polymorphism and OA risk was assessed by odds ratios (ORs) with the corresponding 95% confidence interval (CI) for each study. Results: No significant association between -1607 1G/2G polymorphism and OA risk was found in all the models overall (2G2G vs 1G1G, OR (95%CI) ¼ 0.69 (0.36e1.32), P ¼ 0.54; 2G2G þ 2G1G vs 1G1G, OR (95% CI) ¼ 0.88 (0.47e1.63), P ¼ 0.69; 2G2G vs 2G1G þ 1G1G, OR (95%CI) ¼ 1.30 (0.68e2.47), P ¼ 0.41; 2 G vs 1G, OR (95%CI) ¼ 0.90 (0.86e1.54), P ¼ 0.66). By subgroup analysis, significant association was found in the “< 60 years” group (2G2G vs 1G1G, OR (95%CI) ¼ 3.46 (2.13e5.62), P ¼ 0.00; 2G2G þ 2G1G vs 1G1G, OR (95%CI) ¼ 0.49 (0.31e0.79), P ¼ 0.00; 2G2G vs 2G1G þ 1G1G, OR (95%CI) ¼ 2.74 (1.80e4.16, P ¼ 0.00; 2 G vs 1G, OR (95%CI) ¼ 0.56 (0.35e0.89), P ¼ 0.01). Conclusions: This meta-analysis showed that -1607 1G/2G polymorphism may increase the susceptibility to OA among the younger populations (

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