Association between calcium-phosphorus balance and adolescent idiopathic scoliosis: A meta-analysis
Study design: A systematic review and meta-analysis. Objective: The objective of this meta-analysis was to evaluate the association between calciumphosphorus balance and adolescent idiopathic scoliosis (AIS). Methods: Databases, including PubMed, OVID database, Web of Science, CBM database and CNKI database were searched for the relevant case control studies and cross-sectional studies. Two authors selected studies and extracted data independently. Data analysis was performed by Review Manager Software 5.0. Subgroup analysis was performed on the serum level of vitamin D according to gender and menstruation. Results: Five studies were included, with a total of 646 cases of AIS and 791 controls. AIS group had a lower serum level of vitamin D compared to control group [MD ¼ 6.74, 95% CI (9.47, 4.00)]. Gender and menstruation condition were thought to have no effect on the primary outcome of vitamin D level by subgroup analysis [MD ¼ 5.97, 95% CI (7.61, 4.34)]. The AIS group had a lower calcium level [SMD¼ 0.77, 95% CI (1.51, 0.02)] and calcitonin level compared to control group. There was no statistical difference in phosphorus level [SMD¼0.5, 95% CI (0.46, 0.57)] and parathyroid hormone level [SMD ¼ 0.11, 95% CI (0.54, 0.31)]. Meanwhile, the observational indexes, including serum levels of calcium, phosphorus, parathyroid hormone and calcitonin were within normal limits. Conclusion: Vitamin D deficiency may be involved in the pathogenesis of AIS by influencing the regulation of calcium-phosphors metabolism on human bone. Therefore, we suggest to screen vitamin D level in AIS patients.
___
1. Kennaway D. Cause of idiopathic scoliosis. Spine. 2000;25(19):2552e2553. https://doi.org/10.1007/s00586-009-0927-7.2. Negrini S, Aulisa AG, Aulisa L, et al. 2011 SOSORT guidelines: orthopaedic and rehabilitation treatment of idiopathic scoliosis during growth. Scoliosis. 2012;7(1):3. https://doi.org/10.1186/1748-7161-7-3.
3. Zheng Y, Wu X, Dang Y, Yang Y, Reinhardt JD, Dang Y. Prevalence and determinants of idiopathic scoliosis in primary school children in Beitang district, Wuxi, China. J Rehabil Med. 2016;48(6):547e553. https://doi.org/10.2340/ 16501977-2098.
4. Reichel D, Schanz J. Developmental psychological aspects of scoliosis treatment. Pediatr Rehabil. 2003;6(3e4):221e225. https://doi.org/10.1080/ 13638490310001644593.
5. Allgrove J. Physiology of calcium, phosphate, magnesium and vitamin D. In: Allgrove J, Shaw NJ, eds. Calcium and Bone Disorders in Children and Adolescents. vol. 28. Karger Publishers; 2015:7e32. https://doi.org/10.1159/000380990.
6. Kondo M, Toyoda M, Miyatake H, et al. The prevalence of 25-hydroxyvitamin D deficiency in Japanese patients with diabetic nephropathy. Intern Med. 2016;55(18):2555e2562. https://doi.org/10.2169/internalmedicine.55.6346.
7. Wells G, Shea B, O'Connell D, et al. The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in the Meta-Analysis; 2007. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford. asp. Accessed September , 2017.
8. Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539e1558. https://doi.org/10.1002/Sim.1186.
9. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097. https://doi.org/10.1371/journal.pmed.1000097.
10. Kulis A, Jaskiewicz J. Concentration of selected regulators of calcium-phosphate balance in girls with idiopathic scoliosis. Ortop Traumatol Rehabil. 2009;11(5): 438e447.
11. Batista RMBF, Martins DE, Wajchenberg M, Lazaretti M, Puertas EB, Hayashi LF. Association between vitamin d levels and adolescent idiopathic scoliosis. Coluna/Columna. 2014;13(4):275e278. https://doi.org/10.1590/S1808- 18512014130400432.
12. Lam TP, Ng BKW, Lee KM, et al. Serum 25 (OH) vitamin D level and its correlation with bone mineral density in girls with Adolescent Idiopathic Scoliosis (AIS). Scoliosis. 2015;10(S1):O7. https://doi.org/10.1186/1748-7161-10-S1-O7.
13. Gozdzialska A, Jaskiewicz J, Knapik-Czajka M, et al. Association of calcium and phosphate balance, vitamin D, PTH, and calcitonin in patients with adolescent idiopathic scoliosis. Spine (Phila Pa 1976). 2016;41(8):693e697. https://doi.org/ 10.1097/brs.0000000000001286.
14. Balioglu MB, Aydin C, Kargin D, et al. Vitamin-D measurement in patients with adolescent idiopathic scoliosis. J Pediatr Orthopaedics B. 2017;26(1):48e52. https://doi.org/10.1097/BPB.0000000000000320.
15. Blann A. An update on vitamin D deficiency and at risk groups. J Fam Health. 2015;25(3):16e19.
16. Kalra S, Aggarwal S. Vitamin D deficiency: diagnosis and patient centred management. J Pak Med Assoc. 2015;65(5):569e573.
17. Lamberg-Allardt C. Vitamin D in children and adolescents. Scand J Clin Lab Invest. 2012;72(Suppl 243):124e128. https://doi.org/10.3109/00365513.2012. 682885.
18. Koh AJ, Demiralp B, Neiva KG, et al. Cells of the osteoclast lineage as mediators of the anabolic actions of parathyroid hormone in bone. Endocrinology. 2005;146(11):4584e4596. https://doi.org/10.1210/en.2005-0333.
19. Pialasse JP, Mercier P, Descarreaux M, Simoneau M. Sensorimotor control impairment in young adults with idiopathic scoliosis compared with healthy controls. J Manip Physiol Ther. 2016;39(7):473e479. https://doi.org/10.1016/ j.jmpt.2016.06.001.
20. Man GC, Wang WW, Yim AP, et al. A review of pinealectomy-induced melatonin-deficient animal models for the study of etiopathogenesis of adolescent idiopathic scoliosis. Int J Mol Sci. 2014;15(9):16484e16499. https://doi.org/ 10.3390/ijms150916484.
21. Nowak R, Szota J, Mazurek U. Vitamin D receptor gene (VDR) transcripts in bone, cartilage, muscles and blood and microarray analysis of vitamin D responsive genes expression in paravertebral muscles of juvenile and adolescent idiopathic scoliosis patients. BMC Musculoskelet Disord. 2012;13(1):259. https://doi.org/10.1186/1471-2474-13-259.
22. Ng SY, Bettany-Saltikov J, Cheung IYK, Chan KKY. The role of vitamin D in the pathogenesis of adolescent idiopathic scoliosis. Asian Spine J. 2018;12(6): 1127e1145. https://doi.org/10.31616/asj.2018.12.6.1127.
- ISSN: 1017-995X
- Başlangıç: 2015
- Yayıncı: Türk Ortopedi ve Travmatoloji Derneği
Sayıdaki Diğer Makaleler
Muhammad UMAR, Noman JAHANGİR, Michael HUGHES, Qasim MALİK, Jalal KOKAN, M. WASEEM
Tunay ERDEN, Mehmet KAPICIOĞLU, Abdullah DEMİRTAŞ, Kerem BİLSEL, Fuat AKPINAR, Hacer KUDUZ
Percutaneous fixation of Lisfranc joint injuries: A systematic review of the literature
Ioannis M. STAVRAKAKİS, George E. MAGARAKİS, Zacharias CHRİSTOFORAKİS
Bo XU, Xiao-Qing SHİ, Run-lin XING, Yan-Cheng XİAO, Peng WU, Pei-Min WANG
TAHA ÖZER, Özgür BAŞLARLI, ALPER AKTAŞ, EMRE BARIŞ, HAKAN HAMDİ ÇELİK, Mert OCAK
Ivan MİCİC, Erica KHOLİNNE, Jae-Man KWAK, Kyoung-Hwan KOH, In-Ho JEON
The thickness of heel fat-pad in patients with plantar fasciitis
Oktay BELHAN, Mehmet KAYA, MURAT GÜRGER
Revision strategy for malunited tibial plateau fracture caused by failure of initial treatment
Jiang LİANGJUN, Zheng QİANG, Pan ZHİJUN, Hang Lİ
Double ulnar osteomy for the treatment of congenital radial head dislocation
Qiang JİE, Xiaoju LİANG, Xiaowei WANG, Yongtao WU, Ge WU, Bing WANG