İLHAMİ KURU, Özhan Suna OKTAR, Gökhan MARALCAN, SONER YAYCIOĞLU, M. Eray BOZAN

Ailenin dört üyesinde aynı parmak ve yerleşimde görülen glomus tümörü

Sağ el üçüncü parmağında aşırı duyarlılık ve şiddetli ağrı yakınması ile birçok merkeze başvurduktan sonra bir beyin cerrahı tarafından kliniğimize sevk edilen 35 yaşındaki erkek hastanın öyküsünden yakınmalarının üç yıldır devam ettiği öğrenildi. Sağ el orta parmağının eponişyumu altında hassas, çok ağrılı bir kitle palpe edildi. Kitle glomus tümörü öntanısıyla cerrahi olarak çıkartıldı ve tanı histolojik incelemede doğrulandı. Hastanın aile öyküsünden, aynı şikayetlerin babası ve iki kız kardeşinde de olduğu ve yine sağ el üçüncü parmağın tutulduğu öğrenildi. On yıl önce ameliyat olan babanın kayıtlarının incelenmesi ve kız kardeşlerin muayenesindeki klinik-radyolojik bulgular aynı tanıyı destekliyordu. Parmakta ağrı ve hassasiyet gibi yakınmalar olduğunda, aile bireyleri de sorgulanmalı ve ayırıcı tanıda ailesel glomus tümörü akla getirilmelidir.

Anahtar Kelimeler:

El, El parmakları, Glomus tümörü, Deri neoplazmları, Yumuşak doku neoplazileri

Familial glomus tumor encountered in the same finger and localization in four family members

A 35-year-old man was referred to our clinic by a neurosurgeon for hypersensitivity and severe pain in his right middle finger. History showed that the symptoms had been present for three years and he had made several attempts to seek medical attention. A sensitive, very painful mass was palpated under the eponychium of his right middle finger. The tumor was surgically removed and histological examination confirmed the clinical diagnosis of a glomus tumor. Inquiry into the family history revealed that the same problem existed in the same localization with similar complaints in the father and two daughters. Both the records of the father’s operation 10 years before and clinical-radiological findings of the daughters were consistent with a familial entity. In the presence of hypersensitivity and pain in the finger, family members should be inquired and a diagnosis of familial glomus tumor should be considered.

Keywords:

Hand, Fingers, Glomus Tumor, Skin Neoplasms, Soft Tissue Neoplasms,

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1. Blume-Peytavi U, Adler YD, Geilen CC, Ahmad W, Christiano A, Goerdt S, et al. Multiple familial cutaneous glomangioma: a pedigree of 4 generations and critical analysis of histologic and genetic differences of glomus tumors. J Am Acad Dermatol 2000;42:633-9.
2. Carlstedt T, Lugnegard H. Glomus tumor in the hand. A clinical and morphological study. Acta Orthop Scand 1983;54:296-302.
3. Van Geertruyden J, Lorea P, Goldschmidt D, de Fontaine S, Schuind F, Kinnen L, et al. Glomus tumours of the hand. A retrospective study of 51 cases. J Hand Surg [Br] 1996;21:257-60.
4. Tran LP, Velanovich V, Kaufmann CR. Familial multiple glomus tumors: report of a pedigree and literature review. Ann Plast Surg 1994;32:89-91.
5. Carroll RE, Berman AT. Glomus tumors of the hand: review of the literature and report on twenty-eight cases. J Bone Joint Surg [Am] 1972;54:691-703.
6. Ogino T, Ohnishi N. Ultrasonography of a subungual glomus tumour. J Hand Surg [Br] 1993;18:746-7.
7. Hou SM, Shih TT, Lin MC. Magnetic resonance imaging of an obscure glomus tumour in the fingertip. J Hand Surg [Br] 1993;18:482-3.
8. Ekin A, Ozkan M, Kabaklioglu T. Subungual glomus tumours: a different approach to diagnosis and treatment. J Hand Surg [Br] 1997;22:228-9.
9. Drape JL, Idy-Peretti I, Goettmann S, Wolfram-Gabel R, Dion E, Grossin M, et al. Subungual glomus tumors: evaluation with MR imaging. Radiology 1995;195:507-15.
10. Johnson DL, Kuschner SH, Lane CS. Intraosseous glomus tumor of the phalanx: a case report. J Hand Surg [Am] 1993;18:1026-8.
11. Dailiana ZH, Drape JL, Le Viet D. A glomus tumour with four recurrences. J Hand Surg [Br] 1999;24:131-2.
12. Brouillard P, Boon LM, Mulliken JB, Enjolras O, Ghassibe M, Warman ML, et al. Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations (“glomangiomas”). Am J Hum Genet 2002;70:866-74.
13. van der Mey AG, Maaswinkel-Mooy PD, Cornelisse CJ, Schmidt PH, van de Kamp JJ. Genomic imprinting in hereditary glomus tumours: evidence for new genetic theory. Lancet 1989;2:1291-4.