Gülşah Bayram KABAÇAM, Z. Nilgün Yildirim ÖZBAY, Bige SAYIN, Perihan SOYDİNÇ, Doğan DEDE

Fetal Ouadrigeminal Arachnoid Cyst Secondary to Usage of Valproic Acid

Valproik asit (VPA), sıkça kullanılan, oldukça teratojen olduğu bilinen bir antiepileptik ilaçtır. Özellikle gebeliğin ilk 8 haftasında kullanımıyla teratojenik etkisinin arttığı bilinmektedir. Fetusta oluşan anomaliler arasında birçok sistemik tutulum ve kra-niofasial anomaliler bildirilmiş olmakla beraber daha önce literatürde bildirilen kraniofasial anomaliler arasında araknoid kiste rastlanmamaktadır. Gebeliğinin ilk 8 haftasında VPA kullanmış olan epileptik gebede izlediğimiz fetal araknoid kistin bu antiepi-leptiğin kullanımına bağlı olabileceğini düşünerek, VPA'nın teratojenik spektrumunun bilinenden daha geniş olabileceğini tartışmak amacıyla vakayı sunuyoruz.

Anahtar Kelimeler:

Timoma, ikincil malignite.

Valproik Asit Kullanımına Bağlı Fetal Ouadrigeminal Araknoid Kist

Valproic acid (VPA) is a commonly used antiepileptic drug, that is well known to be a potent teratogen. Especially, its use in the 8 weeks of pregnancy increases this teratogenic potential. Among these anomalies caused by VPA are many forms of syste-mic involvement and craniofacial anomalies, however there was no case of arachnoid cyst. Here, we present a case of fetal arachnoid cyst in an epileptic pregnant vvomen who used VPA which is the most probable reason for this teratogenic effect, to draw attention to teratogenic spectrum of VPA.

Keywords:

Thymoma, Second malignaney.,

PDF

___

Wide K, VVinbladh B, Kallen B. Majör malformations in infants exposed to antiepileptic drugs in utero, with empha- sis on carbamazepine and valproic acid: A nation-wide, population-based 2004;93:174-6. study. Açta Paediatr
Iqbal MM. The effects of lithium, valproic acid, and carba mazepine during pregnancy and lactation. J Toxicol Clin Toxicol 2001;39:381-92.
Gurvich N. Association of valproate-induced teratogenesis with histone deacetylase inhibition in vivo. FASEB J 2005;19:1166-8.
Ceylan S, Duru S, Ceylan S. Valproic acid sodium-induced spina bifida occulta in the rat. Neuro Surg Rev 2001;24:31- 4.
Alsdorf R, VVyszynski DF. Teratogenicity o f sodium valproa- te. Expert Opin Drug S af2005;4:354-53.
Robinson RG: Congenital cysts of the brain: Arachnoid mal formations. Prog Neurol Surg 1971;4:133.
Russell DS, Rubinstein LJ. Pathology of tumors of the ner- vous system, 5,h ed. VVİlliams & Wilkins, Baltimore, 1989.
VVester K. Pecullarities of intrakranial arachnoid cysts: Location, sidedness and sex distribution in 126 consecutive patients. Neuro Surg 1999;45:775-9.
Tahsin E. Intracranial arachnoid cysts: Clinical features and management of 35 cases and review of the literatüre. Neuro Surgery ûuarterly 2004;14:84-9.
Hidalgo H, Bowie J, Rosenberg ER, et al. İn utero sonog raphic diagnosis of fetal cerebral anomalies. AJR 1982; 139: 143-8.
Tae-Hee Kwon, Philippe Jeanty. Supratentorial arachnoid cyst. 1991-01-08-17 © Kwon
F. Bretelle, Senat MV, Bernard JP. First-trimester disgnosis of fetal arachnoid cyst: Prenatal implication. Ultrasound in Obstet & Gynecol 2002;20:400-2.
Pllu G, Rizzo N, Orsini LF, et al: Antenatal detection of cerebral anomalies. Ulirasound Med Biol 1986;12:319.
Nyberg DA, Pretorius DH: Cerebral malformations. in Ultrasound of fetal anomalies. Nyberg DA, Pretorius DH, Mahony B (eds.) Year Book, Chicago 1990;83-145.
Romero R, Pilu G, Jeanty P, et al. Prenatal diagnosis of con genital anomalies. Appleton & Lange, Norvvalk, Connecticut, 1988.