Kök kanal ilaçları

Pulpa ve periapikal doku hastalıklarında bakterilerin rolü olduğu gösterilmiştir. Kök kanal tedavisinin başarısında kök kanal sisteminin bakterilerden arındırılması önemli rol oynamaktadır. Bunun sağlanabilmesi için, kök kanallarının biyomekanik şekillendirmesi, antimikrobiyal ajanlarla yı- kanması ve kanal içi ilaçların uygulanması gibi aseptik tedavi yöntemlerinin bir arada kullanılması gereklidir. Kök kanal dezenfeksiyonun sağlanması için kanal içinde bir- çok ilaç kullanılmıştır. Bu derlemede endodontide sıklıkla kullanılan kanal içi ilaçlar anlatılmaktadır. Kök kanal enfeksiyonlarının tedavisi için kanal içinde kullanılacak en iyi ilacın belirlenebilmesi için daha fazla çalışma yapılması gerekmektedir.

Root canal medicaments

Bacteria have been implicated in the pathogenesis and progression of pulpal and periapical diseases. The success of root canal treatment largely depends on bacterial elimination from the root canal system. This can be achieved by using combination of aseptic treatment techniques, biomechanical preparation of the root canal, irrigation with antimicrobial solutions and use of intracanal medicaments. Various medicaments have been used to achieve disinfection of the root canal system. This review deals with medicaments commonly used in endodontics. Further research is required to determine the best medicament to be used in the treatment of root canal infections.

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  • Spangberg LSW, Haapasalo M. Rationale and efficacy of root canal medicaments and root filling materials with the emphasis on treatment outcome. Endod Topics 2002;2: 35-58.
  • Abbott PV. Medicaments: aids to success in endodontics. Part 1. A review of the literature. Aust Dent J 1990;35:438-48.
  • Athanassiadis B, Abbott PV, Walsh LJ. The use of calcium hydroxide, antibiotics and biocides as antimicrobial medicaments in endodontics. Aust Dent J 2007;52:S64-82.
  • Siqueira JF Jr, Lopes HP. Mechanisms of antimicrobial activity of calcium hydroxide: a critical review. Int Endod J 1999;32:361-9.
  • Walton RE. Intracanal medicaments. Dent Clin North Am 1984;28:783-96.
  • Messer HH, Chen RS. The duration of effectiveness of root canal medicaments. J Endod 1984;10:240-5.
  • Lewis BB, Chestner SB. Formaldehyde in dentistry: a review of mutagenic and carcinogenic potential. J Am Dent Assoc 1981;103:429-34.
  • Haapasalo M, Endal U, Zandi H, Coil JM. Eradication of endodontic infection by instrumentation and irrigation solutions. Endod Topics 2005;10:77-102.
  • Molander A, Reit C, Dahlén G. The antimicrobial effect of calcium hydroxide in root canals pretreated with 5% iodine potassium iodide. Endod Dent Traumatol 1999;15:205-9.
  • Mohammadi Z, Abbott PV. The properties and applications of chlorhexidine in endodontics. Int Endod J 2009;42:288-302.
  • Grenier D. Effect of chlorhexidine on the adherence properties of Porphyromonas gingivalis. J Clin Periodontol 1996;23:140-2.
  • Rosenthal S, Spångberg L, Safavi K. Chlorhexidine substantivity in root canal dentin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004;98:488-92.
  • Tanomaru JM, Leonardo MR, Tanomaru Filho M, Bonetti Filho I, Silva LA. Effect of different irrigation solutions and calcium hydroxide on bacterial LPS. Int Endod J 2003;36:733-9.
  • Zerella JA, Fouad AF, Spångberg LS. Effectiveness of a calcium hydroxide and chlorhexidine digluconate mixture as disinfectant during retreatment of failed endodontic cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;100:756-61.
  • Haenni S, Schmidlin PR, Mueller B, Sener B, Zehnder M. Chemical and antimicrobial properties of calcium hydroxide mixed with irrigating solutions. Int Endod J 2003;36:100-5.
  • Gomes BP, Sato E, Ferraz CC, Teixeira FB, Zaia AA, Souza-Filho FJ. Evaluation of time required for recontamination of coronally sealed canals medicated with calcium hydroxide and chlorhexidine. Int Endod J 2003;36:604-9.
  • Basrani BR, Manek S, Sodhi RN, Fillery E, Manzur A. Interaction between sodium hypochlorite and chlorhexidine gluconate. J Endod 2007;33:966-9.
  • Fava LR, Saunders WP. Calcium hydroxide pastes: classification and clinical indications. Int Endod J 1999;32:257-82.
  • Bystrom A, Claesson R, Sundqvist G. The antibacterial effect of camphorated paramonochlorophenol, camphorated phenol and calcium hydroxide in the treatment of infected root canals. Endod Dent Traumatol 1985;1:170-5.
  • Tang G, Samaranayake LP, Yip HK. Molecular evaluation of residual endodontic microorganisms after instrumentation, irrigation and medication with either calcium hydroxide or Septomixine. Oral Dis 2004;10:389-97.
  • Heithersay GS. Calcium hydroxide in the treatment of pulpless teeth with associated pathology. J Br Endod Soc 1975;8:74-93.
  • Deveaux E, Dufour D, Boniface B. Five methods of calcium hydroxide intracanal placement: an in vitro evaluation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;89:349-55.
  • Sigurdsson A, Stancill R, Madison S. Intracanal placement of Ca(OH)2: a comparison of techniques. J Endod 1992;18:367-70.
  • Lawson BF, Mitchell DF. Pharmacologic treatment of painful Pulpitis. A preliminary, controlled, double-blind study. Oral Surg Oral Med Oral Pathol 1964;17:47-61.
  • Abbott PV, Hume WR, Heithersay GS. Effects of combining Ledermix and calcium hydroxide pastes on the diffusion of corticosteroid and tetracycline through human tooth roots in vitro. Endod Dent Traumatol 1989;5:188-92.
  • Santini A. Long-term clinical assessment of pulpotomies with calcium hydroxide containing Ledermix in human permanent premolars and molars. Acta Odontol Pediatr 1986;7:45-50.
  • Ehrmann EH, Messer HH, Adams GG. The relationship of intracanal medicaments to postoperative pain in endodontics. Int Endod J 2003;36:868-75.
  • Trope M, Delano EO, Orstavik D. Endodontic treatment of teeth with apical periodontitis: single vs. multivisit treatment. J Endod 1999;25:345-50.
  • Porkaew P, Retief DH, Barfield RD, Lacefield WR, Soong SJ. Effects of calcium hydroxide paste as an intracanal medicament on apical seal. J Endod 1990;16:369-74.
  • Calt S, Serper A. Dentinal tubule penetration of root canal sealers after root canal dressing with calcium hydroxide. J Endod 1999;25:431-3.
  • Mohammadi Z. Systemic and local applications of steroids in endodontics: an update review. Int Dent J 2009;59:297-304.
  • Mohammadi Z, Abbott PV. On the local applications of antibiotics and antibiotic-based agents in endodontics and dental traumatology. Int Endod J 2009;42:555-67.
  • Gilad JZ, Teles R, Goodson M, White RR, Stashenko P. Development of a clindamycin-impregnated fiber as an intracanal medication in endodontic therapy. J Endod 1999;25:722-7.
  • Grossman LI. Polyantibiotic treatment of pulpless teeth. J Am Dent Assoc 1951;43:265-78.
  • Grieve AR, Friend LA, Plant CG. A clinical trial of three root canal medicaments. Br Dent J 1973;134:188-93.
  • Abbott PV, Hume WR, Pearman JW. Antibiotics and endodontics. Aust Dent J 1990;35:50-60.
  • Bryson EC, Levin L, Banchs F, Abbott PV, Trope M. Effect of immediate intracanal placement of Ledermix Paste(R) on healing of replanted dog teeth after extended dry times. Dent Traumatol 2002;18:316-21.
  • Ehrmann EH. THE effect of triamcinolone with tetracycline on the dental pulp and apical periodontium. J Prosthet Dent 1965;15:144-52.
  • Barkhordar RA, Watanabe LG, Marshall GW, Hussain MZ. Removal of intracanal smear by doxycycline in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;84:420-3.
  • Haznedaroğlu F, Ersev H. Tetracycline HCl solution as a root canal irrigant. J Endod 2001;27:738-40.
  • Abbott PV, Heithersay GS, Hume WR. Release and diffusion through human tooth roots in vitro of corticosteroid and tetracycline trace molecules from Ledermix paste. Endod Dent Traumatol 1988;4:55-62.
  • Matthews RW, Peak JD, Scully C. The efficacy of management of acute dental pain. Br Dent J 1994;176:413-6.
  • Kim ST, Abbott PV, McGinley P. The effects of Ledermix paste on discolouration of immature teeth. Int Endod J 2000;33:233-7.
  • Molander A, Reit C, Dahlén G. Microbiological evaluation of clindamycin as a root canal dressing in teeth with apical periodontitis. Int Endod J 1990;23:113-8.
  • Hoshino E, Kurihara-Ando N, Sato I, Uematsu H, Sato M, Kota K, et al. In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline. Int Endod J 1996;29:125-30.
  • Roche Y, Yoshimori RN. In-vitro activity of spiramycin and metronidazole alone or in combination against clinical isolates from odontogenic abscesses. J Antimicrob Chemother 1997;40:353-7.
  • Windley W 3rd, Teixeira F, Levin L, Sigurdsson A, Trope M. Disinfection of immature teeth with a triple antibiotic paste. J Endod 2005;31:439-43.
  • Sato I, Ando-Kurihara N, Kota K, Iwaku M, Hoshino E. Sterilization of infected root-canal dentine by topical application of a mixture of ciprofloxacin, metronidazole and minocycline in situ. Int Endod J 1996;29:118-24.
  • Takushige T, Cruz EV, Asgor Moral A, Hoshino E. Endodontic treatment of primary teeth using a combination of antibacterial drugs. Int Endod J 2004;37:132-8.
  • Iwaya SI, Ikawa M, Kubota M. Revascularization of an immature permanent tooth with apical periodontitis and sinus tract. Dent Traumatol 2001;17:185-7.
Acta Odontologica Turcica-Cover
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1984
  • Yayıncı: Gazi Üniversitesi Diş Hekimliği Fakültesi Dergisi
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