Bertan AKAR, Emre KÖLE, Canan ÖZCAN, Merve ÇAKIR KÖLE

Serbest fetal DNA fraksiyonu plasental problemlere bağlı gebelik sonuçlarında değişir mi?

Amaç: Cff-DNA’nın non-invazif tanı uygulamaları dışında, bu biyobelirtecin preeklampsi, IUGR, preterm doğum gibi önemli obstetrik komplikasyonları belirlemede yerini araştırmak. Yöntemler: Çalışmamız eylül 2019-mart 2020 tarihleri arasında, kliniğimize başvuran 10-24. Gebelik haftaları arasında kendi isteği, ileri anne yaşı olan (≥40) ve ikili testte artmış trizomi 13, 18 ve 21 riski nedeniyle serbest fetal DNA analizi (HarmonyTM Prenatal Test; Ariosa Diagnostics Inc., San Jose, Calif., USA) yapılan 131 hastalarda tek merkezli retrospektif çalışma olarak planlandı. Bulgular: Çalışmamızda hastaların 10’ unda (%8,1) oligohidramnios, 10’ unda (%8,1) gestasyonel diyabet, 7’ sinde de (%8,6) preeklampsi gözlenmiştir. 2 hastada da (%1,2) dekolman plasenta izlenmiştir. 10-24. gebelik haftaları arası ölçülen hücre dışı fetal DNA fraksiyonlarının artmış düzeyleri IUGR ile sonuçlanan gebelikleri öngörmede anlamlı bulunmuştur (p

Anahtar Kelimeler:

cffDNA, gebelik, plasenta, gebelik sonuçları

DO THE LEVELS OF cffDNA FRACTION CHANGE IN PREGNANCIES WITH PLACENTAL PROBLEMS?

Aim : To investigate the value of the cell free fetal DNA (cff-DNA) for determining the important obstetric complications such as preeclampsia, intrauterine growth retardation (IUGR) and, preterm labor other than prenatal screening of fetal aneuploidies. Material and Methods : Our single center- retrospective study included 131 pregnant women in their 10-24th weeks of gestation, between the dates September 2019 and March 2020 who applied for cff-DNA analysis (HarmonyTM Prenatal Test; Ariosa Diagnostics Inc., San Jose, Calif., USA) with indications including advanced maternal age (≥40) and high risk for trisomy 13, 18 and 21 according to the results of the first trimester prenatal screening or solely on their own desire. Results : Oligohydraamnios was observed in 10 (%8,1) patients, gestational diabetes in 10 patients (%8,1) , preeclampsia in 7 ( %8,6) patients and ablatio plasenta in 2 (%1,2) patients in this study. Increasing levels of the extracellular fetal DNA fractions in 10-24th gestational weeks showed statistically significant correlation for predicting the risk for IUGR (p

Keywords:

cffDNA, pregnancy, placenta, pregnancy outcomes,

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