İhsan ÇETİN, Selçuk AKIN, M Tahir NALBANTÇILAR, Nazlı KOÇ, Kezban TOSUN

İçme Suyu Metal Element İçeriği ile Batman'da Yaşayan Bireylerin Vücut Kompozisyonları Arasındaki İlişki

Amaç: Önceki çalışmalar mikro element düzeylerinin kilo kaybına katkı sağlayabileceğini göstermiştir. Ancak, içme suyu mikro element düzeyleri ile vücut kompozisyonları arasındaki potansiyel ilişkiyi analiz eden kapsamlı bir çalışma bulunmamaktadır. Bu çalışmada, içme suyunda bulunan mikro element düzeyleri ile normal, kilolu ve obez kişilere ait vücut kompozisyonları arasındaki ilişkinin incelenmesi amaçlanmıştır. Yöntem: Bu çalışmaya, Devlet Hastanesi Diyet Polikliniğine başvuran ve vücut kütle indeksi (VKİ) referans değerlerine göre normal, kilolu ve obez olarak üç gruba ayrılan, 55-70 yaş aralığında toplam 345 kadın dâhil edilmiştir. Su örnekleri kütle spektrometresi ile analiz edildi ve vücut kompozisyonu ölçümleri biyoelektrik impedans analizi ile yapılmıştır. Bulgular: Kadınlara ait obezite yüzdesi, içme suyu kobalt (Co) ve selenyum (Se) düzeyleri ile pozitif korelasyon gösterdi. Ayrıca, kadınlara ait VKİ değerlerinin içme suyu krom (Cr) düzeyleri ile pozitif korele olduğu bulundu. Sonuç: Co, Se ve Cr yüksek düzeyde içeren içme suyu tüketen kadınların obezitenin gelişmesi açısından daha büyük bir risk altında olabileceği öne sürülebilir. Diğer taraftan, içme suyu mikro element seviyelerinin obezite ile ilişkili kan parametrelerine etkisi belirsizdir ve daha fazla araştırmayı hak etmektedir.

Anahtar Kelimeler:

Obezite, beden kitle indeksi, kobalt, selenyum, krom, Obezite, beden kitle indeksi, kobalt, selenyum, krom, Obesity, body mass index, cobalt, selenium, chromium

The Relationship Between Metal Element Content of Drinking Water and Body Compositions of People in Batman

Objective: Previous studies showed that the levels of micro elements may have a contribution to weight loss. Nevertheless, it is not possible to find many comprehensive studies analysing the potential relation between micro elements found in water used for drinking purposes and body composition. The present study aims to assess the relation between micro element levels of drinking water and body composition in normal, fat and obese subjects. Methods: The study consisted of 345 female participants, who were divided into 3 groups of 115, according to body mass index (BMI) for leanness, overweight, and obesity; and who applied to Diet Polyclinic of State Hospital. Water samples were analysed with mass spectrometry; and body composition measurements were conducted via bioelectrical impedance analysis. Results: The obesity percentage in females demonstrated statistically positive correlations with cobalt (Co) and selenium (Se) in water for drinking. Also, it was found that the BMI values of females significantly positively correlated with chromium (Cr). Conclusion: It may be suggested that women who consume drinking water containing high levels of Co, Se and Cr might be at a greater risk of developing obesity. On the other hand, the lack of knowledge about influence of levels of micro elements in drinking water on blood parameters associated with obesity or tissue remains unclear and deserves more investigation.

Keywords:

Obesity, body mass index, cobalt, selenium, chromium,

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Grundy SM. Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab. 2004;89(6):2595-2600. doi:10.1210/jc.2004-0372
Haslam DW, James WP. Obesity. Lancet. 2005;366(9492):1197-1209. doi:10.1016/S0140-6736(05)67483-1
Yerlikaya H, Toker A. Obesity and trace elements. Dialog Endocrinol 2012;9(2): 64-70
Gillum RF. Association of serum ferritin and indices of body fat distribution and obesity in Mexican American men: the Third National Health and Nutrition Examination Survey. Int J Obes Relat Metab Disord. 2001;25(5):639-645. doi:10.1038/sj.ijo.0801561
Zimmermann MB, Zeder C, Muthayya S, et al. Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification. Int J Obes (Lond). 2008;32(7):1098-1104. doi:10.1038/ijo.2008.43
Lecube A, Carrera A, Losada E, Hernández C, Simó R, Mesa J. Iron deficiency in obese postmenopausal women. Obesity (Silver Spring). 2006;14(10):1724-1730. doi:10.1038/oby.2006.198
Manios Y, Moschonis G, Chrousos GP, et al. The double burden of obesity and iron deficiency on children and adolescents in Greece: the Healthy Growth Study. J Hum Nutr Diet. 2013;26(5):470-478. doi:10.1111/jhn.12025
Cheng HL, Bryant C, Cook R, O'Connor H, Rooney K, Steinbeck K. The relationship between obesity and hypoferraemia in adults: a systematic review. Obes Rev. 2012;13(2):150-161. doi:10.1111/j.1467-789X.2011.00938.x
Tuormaa TE. Chromium, Selenium, Copper and other Trace Minerals in Health and Reproduction. J Orthomol Med. 2000;15(3):145-57
Olusi S, Al-Awadhi A, Abiaka C, Abraham M, George S. Serum copper levels and not zinc are positively associated with serum leptin concentrations in the healthy adult population. Biol Trace Elem Res. 2003;91(2):137-144. doi:10.1385/BTER:91:2:137
Novakova S, Nikolchev G, Mautner G, Angelieva R, Dinoeva S. Prouchvane vliianieto na niakoi mikroelementi, sudurzhashti se v piteĭnite vodi, vurkhu razvitieto na aterosklerozata [Effect of several microelements contained in drinking water on the development of atherosclerosis]. Probl Khig. 1983;8:121-131
Bagriacik N, Onat H, Ilhan B, et al. Obesity Profile in Turkey. Int J Endocrinol Metab. 2009;17(1): 5-8. doi:10.1159/000497665
Błoniarz J, Zareba S. Selected microelements [Cr, Zn, Cu, Mn, Fe, Ni] in slimming preparations. Rocz Panstw Zakl Hig. 2007;58(1): 165-70
World Health Organization. Calcium and Magnesium in Drinking-water: Public health significance. https://www.who.int/publications/i/item/9789241563550. Published: Mar. 2009. Accessed: Mar 8, 2016
World Health Organization. Guidelines for Drinking-water Quality. 4th Edition. https://www.who.int/publications/i/item/9789241549950. Published: Jun. 2011. Accessed: Mar 8, 2016
Neovius M, Hemmingsson E, Freyschuss B, Uddén J. Bioelectrical impedance underestimates total and truncal fatness in abdominally obese women. Obesity (Silver Spring). 2006;14(10):1731-1738. doi:10.1038/oby.2006.199
Lee SY, Gallagher D. Assessment methods in human body composition. Curr Opin Clin Nutr Metab Care. 2008;11(5):566-572. doi:10.1097/MCO.0b013e32830b5f23
APHA. Standard methods for the examination of water and wastewater. American Public Health Association Washington, DC, USA. 1992. ACME. Methods and specifications for analytical package, Group 2C & 2D-Water Analysis by ICP-MS [www.acmelab.com], 2005
Nicolai A, Li M, Kim DH, et al. Heme oxygenase-1 induction remodels adipose tissue and improves insulin sensitivity in obesity-induced diabetic rats. Hypertension. 2009;53(3):508-515. doi:10.1161/HYPERTENSIONAHA.108.124701
Kawakami T, Hanao N, Nishiyama K, et al. Differential effects of cobalt and mercury on lipid metabolism in the white adipose tissue of high-fat diet-induced obesity mice. Toxicol Appl Pharmacol. 2012;258(1):32-42. doi:10.1016/j.taap.2011.10.004
Laclaustra M, Navas-Acien A, Stranges S, Ordovas JM, Guallar E. Serum selenium concentrations and hypertension in the US Population. Circ Cardiovasc Qual Outcomes. 2009;2(4):369-376. doi:10.1161/CIRCOUTCOMES.108.831552
Papp LV, Lu J, Holmgren A, Khanna KK. From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid Redox Signal. 2007;9(7):775-806. doi:10.1089/ars.2007.1528
Stranges S, Sieri S, Vinceti M, et al. A prospective study of dietary selenium intake and risk of type 2 diabetes. BMC Public Health. 2010; 10:564. doi:10.1186/1471-2458-10-564
Steinbrenner H, Speckmann B, Pinto A, Sies H. High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism. J Clin Biochem Nutr. 2011;48(1):40-45. doi:10.3164/jcbn.11-002FR
Kawakami T, Sugimoto H, Furuichi R, et al. Cadmium reduces adipocyte size and expression levels of adiponectin and Peg1/Mest in adipose tissue. Toxicology. 2010;267(1-3):20-26. doi:10.1016/j.tox.2009.07.022
Mertz W. Chromium occurrence and function in biological systems. Physiol Rev. 1969;49(2):163-239. doi:10.1152/physrev.1969.49.2.163
Hasten DL, Rome EP, Franks BD, Hegsted M. Effects of chromium picolinate on beginning weight training students. Int J Sport Nutr. 1992;2(4):343-350. doi:10.1123/ijsn.2.4.343
Jain SK, Kahlon G, Morehead L, et al. Effect of chromium dinicocysteinate supplementation on circulating levels of insulin, TNF-α, oxidative stress, and insulin resistance in type 2 diabetic subjects: randomized, double-blind, placebo-controlled study. Mol Nutr Food Res. 2012;56(8):1333-1341. doi:10.1002/mnfr.201100719
TS-266 (2005) Turkish regulation concerning water intended for human consumption. Institute of Turkish Standard, Ankara, Turkey.
WHO (2022) Guidelines for drinking-water-quality: Fourth edition incorporating the first and second addenda, World Health Organization, Geneva