Aydın ÇORAKÇI, Semih ÖZEREN, İzzet YÜCESOY, Ramazan MERCAN, Gülseren YÜCESOY, Metin ÇAPAR

Erken Gebelikte Progesteron Tedavisinin Hormonal ve Klinik Etkileri

Çalışmamızda erken gebelikte tartışmalı bir konu olan progesteron tedavisinin hormonal ve klinik etkilerini araştırıp progesteron tedavisi uygulanacak hastaları seçmek için protokol geliştirmeyi amaçladık. Düşük tehdidi bulguları ile başvuran 6-9 haftalık 48 gebe iki gruba ayrıldı. Grup I'e tedavi verilmedi, grup II'ye 250 mg 17 OH progesteron kapronat İM verildi. Bir hafta sonra progesteron, estradiol, hCG, ve 17 OH progesteron değişiklikleri izlenerek 2 grup karşılaştırıldı. Grup I'de 24 hastanın 3'ünde (%12,5), grup II'de 24 hastanın 2'sinde (%8,33) düşük gerçekleşti. Ancak hormonal değerler arasında anlamlı bir fark gözlenmedi.Çalışmamızda elde ettiğimiz sonuçlara dayanarak progesteronu 10 ng/ml'nin altında olan olası luteal faz defekti bulunan düşük tehdidi bulguları gösteren hastalara ultrasonografi ile fetusun viabilitesi tespit edildikten sonra progesteron tedavisinin yararlı olabileceği kanaatine vardık.

Anahtar Kelimeler:

Erken gebelik, progesteron tedavisi, luteal faz defekti

Hormonal and Clinical Effects of Progesterone Therapy in Early Pregnancy

The purpose of this study was to evaluate the clinical and hormonal effects of progesterone treatment in early pregnancy and to establish a protocol to determine the patients who would benefit from progesterone treatment. 48 women who were admitted with the signs of threatened abortion and had gestational ages ranged from 6 to 9 weeks were divided into two groups. Group I did not receive any treatment while group II received 250 mg 17 OH Progesterone capronate intramuscularly. One week later, serum levels of progesterone, estradiol, hCG, and 17 OH Progesterone were measured and the results of each group were compared. Abortion occurred in 3 of 24 (12.5%) woman in group I and 2 of 24 (8.33%) women in group II. No significant differences between hormonal measurements were noted in both groups. We conclude that after detecting fetal viability by ultrasonography, progesterone treatment might be useful in patients with threatened abortion who have a progesterone level less than 10 ng/ml and who probably have a luteal phase defect.

Keywords:

Early pregnancy, progesterone treatment, luteal phase defect,

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