KÜTANÖZ LIKEN PLANUSTA STANDART KONTAKT ALLERJENLERE AŞIRI DUYARLILIK

Amaç: Liken planus, lenfositik enflamasyonla karakterize hücresel immün sistemin rol oynadığı nedeni bilinmeyen bir hastalıktır. Belirli antijenlere karşı kontakt aşırı duyarlılığın başta oral liken planus olmak üzere kütanöz liken planusta da bulunduğunu gösteren çalışmalar giderek artmaktadır. Buna karşın T hücre aracılı bu hastalıkta kontakt aşırı duyarlılık cevabında herhangi bir değişiklik olup olmadığını sorgulayan az sayıda çalışma mevcuttur. Hastalar ve Yöntem: Bu çalışmanın amacı kütanöz liken planuslu hastalarda standart kontakt allerjenlere karşı oluşan aşırı duyarlılık reaksiyonlarının prevalansını saptamaktır. Bu çalışmada kütanöz liken planus tanısı konulan 43 kişilik hasta grubuna ve 33 kişilik kontrol grubuna T.R.U.E test metolojisi ile yama testi uygulanmıştır. Bulgular: Hasta grubunda yama testi pozitifliği %11.6, kontrol grubunda %30.3 olarak bulunmuştur. İki grup arasındaki fark istatistiki olarak anlamlı değildir. Fischer testi p=0.07 . Sonuç: Bu çalışma kütanöz liken planusta yama testi pozitifliğini araştıran ilk çalışmadır ve hasta grubunun kontrol grubundan farklı olmadığı sonucuna varılmıştır

Hypersensitivity To Standard Contact Allergens In Patients With Cutaneous Lichen Planus

Aim: Lichen planus is a lymphocytic inflammatory disorder of unknown origin mediated by cellular immunity. The reports documenting contact hypersensitivity to certain antigens are increasing in number mainly in oral but also in cutaneous lichen planus as well. However, there are only a few studies questioning whether there is any alteration in contact hypersensitivity response in this patient group due to T-cell mediated changes. Methods: The purpose of this study is to find out the prevalence of contact hypersensitivity to standard contact allergens in cutaneous lichen planus patients. In the present study 43 cutaneous lichen planus patients and 33 controls were patch tested by T.R.U.E test methodology. Resulst: A positive patch test reaction was found in 11.6% of the lichen planus patients while the control group showed a percentage of 30.3%. Statistically, the difference between the two groups was not significant Fischer test p=0.07 . Conclusions: This is the first study examining into the standard patch test positivity in cutaneous lichen planus patients the results showed no difference from the control

Keywords:

contact hypersensitivity, lichen planus, cutaneous lichen planus patch test, T.R.U.E. test,

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