Düşük Serum D Vitamin Düzeylerine Parathormon Yanıtını Etkileyen Faktörler

Amaç: Serum 25 OH D vitamini düşüklüğü olan hastalarda parathormon PTH yanıtı üzerine etkili faktörleri ortaya koymaktır.Gereç ve yöntem: Bu çalışma retrospektif tanımlayıcı bir çalışmadır. 2015 Ocak-2019 Haziran aylarında İstanbul Fizik Tedavi Rehabilitasyon Eğitim ve Araştırma Hastanesi polikliniklerine başvuran, veri tabanından eş zamanlı bakılan kan biyokimyasında serum 25 OH D vitamini ve PTH değerleri çalışılmış olan hastalar tarandı. 25 OH D vitamini değeri

Factors Affecting Parathormone Response To Low Serum Vitamin D Levels

Objective: The aim of the study is to determine the factors affecting parathormone PTH response induced in patients with low serum 25 OH vitamin D levels.Materials and methods: This is a retrospective descriptive study. The patients whom serum 25 OH vitamin D and PTH levels were examined together were included in our study in Istanbul in Physical Therapy Rehabilitation Education and Research Hospital between 2015 and 2019. Patients with 25 OH vitamin D values lower than 30 ng/mL were included in the study. The patients 17 years and under; the patients with abnormal creatinine, albumin, calcium and phosphorus levels and the patients with PTH levels lower than 12 pg/mL were excluded from the study. Age, sex, seasonal hospital admission, serum 25 OH vitamin D and PTH levels were examined.Results: The mean age of the 334 patients included in the study was 49.1±17.7 years. The mean serum 25 OH vitamin D level was 14.5±7.6 ng/mL and the mean PTH level was 49.3±26.5 pg/mL. 34.4% of the patients had severe 25 OH vitamin D deficiency, 37.4% of the patients had 25 OH vitamin D deficiency and 28.1% of the patients had 25 OH vitamin D insufficiency. Hyperparathyroidism was found in 6.3% of all cases. Hyperparathyroidism was found to be significantly more frequent in patients with severe 25 OH vitamin D deficiency. There was a negative correlation between serum PTH and 25 OH vitamin D levels. There was a positive correlation between age and serum PTH levels. There was no relationship with 25 OH vitamin D level, gender and seasonal distribution.Conclusion: Low 25 OH vitamin D induced PTH elevation is not only dependent on vitamin D levels, but also age. PTH levels were found to be higher in patients with low vitamin D while age increased

Keywords:

25 OH vitamin D, parathyroid hormone parathormone response,

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