COVİD-19: İlk Semptom Olarak Koku ve Tat Disfonksiyonu

Aralık 2019’da Çin’in Wuhan kentinden kaynaklandığı düşünülen ve milyonlarca kişinin enfekte olmasına neden olan koronavirus bir pandemiye yol açmıştır. Enfeksiyonun ilk dönemlerinde sıklıkla görülen semptomlar ateş, miyalji ve öksürük olarak bildirilmiştir. Biz bu yazıda başlangıç bulguları olarak sadece koku ve tat alma fonksiyonunda kaybolma şikayeti ile gelen iki hastayı inceledik. Testleri pozitif çıkan ve pnömoni tanısı konan hastalarda öksürük ve ateş görülmedi. Sadece tat ve koku duyularının kaybolduğu hastaların mutlaka test ile taranması gerektiğini düşünmekteyiz.Anahtar Sözcükler: Kovid-19, pandemi, koku disfonksiyonu, tat disfonksiyonu

Olfactory and Taste Dysfunction as an Initial Symptom of COVID-19

The coronavirus assumed to have originated in Wuhan China, has infected millions of people since December 2019, resulting in a pandemic. Recent changes in symptoms are observed in Covid-19 positive patients, whose symptoms were reported as fever, myalgia and cough in the earlier cases. In this paper we presented two cases where the initial symptom was loss of taste and smell sensation. Both of these patients were diagnosed pneumonia though neither of them had cough nor fever. Considering the positive outcomes with medical treatment, we claim these patients with the only symptom, loss of smell and taste, should be tested for Covid-19.Keywords:Covid-19, pandemic, olfactory dysfunction, taste dysfunction

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  • 1. Mahony JB, Petrich A, Smieja M. Molecular diagnosis of respiratory virus infections. Crit Rev Clin Lab Sci. 2011;48:217-49.
  • 2. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X, Cheng Z, Yu T, Xia J, Wei Y, Wu W, Xie X, Yin W, Li H, Liu M, Xiao Y, Gao H, Guo L, Xie J, Wang G, Jiang R, Gao Z, Jin Q, Wang J, Cao B. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.Lancet. 2020 Feb 15;395(10223):497-506.
  • 3. Detection of parainfluenza virus 3 in turbinate epithelial cells of postviral olfactory dysfunction patients.Wang JH1, Kwon HJ, Jang YJ. Laryngoscope. 2007 Aug;117(8):1445-9.
  • 4. Identification of Viruses in Patients With Postviral Olfactory Dysfunction Motohiko Suzuki, Koichi Saito, Wei-Ping Min, Costin Vladau, Kazunori Toida, Hirotaka Itoh, Shingo Murakami. Laryngoscope, 117:272–277, 2007
  • 5. Stroop MG. Viruses and the olfactory system. In: Doty RL, editor. Handbook of olfaction and gustation. New York: Marcel Dekker; 1995. p. 367–94
  • 6. Yamagishi M, Fujiwara M, Nakamura H. Olfactory mucosal findings and clinical course in patients with olfactory disorders following upper respiratory viral infection. Rhinology 1994;32:113–8
  • 7. Perlman S, Evans G, Afifi A. Effect of olfactory bulb ablation on spread of a neurotropic coronavirus into the mouse brain. J Exp Med 1990;172:1127–32
  • 8. Behavioural deficits and serotonin depletion in adult rats after transient infant nasal viral infection. Mohammed AK1, Magnusson O, Maehlen J, Fonnum F, Norrby E, Schultzberg M, Kristensson K. Neuroscience. 1990;35(2):355-63.
  • 9. An SS, Liggett SB. Taste and smell GPCRs in the lung: evidence for apreviously unrecognized widespread chemosensory system. Cell Signal. 2018;41:82-88. doi:10.1016/j.cellsig.2017.02.002
Acıbadem Üniversitesi Sağlık Bilimleri Dergisi-Cover
  • ISSN: 1309-470X
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2010
  • Yayıncı: ACIBADEM MEHMET ALİ AYDINLAR ÜNİVERSİTESİ