Çevresel Guatrojenler NIS İnhibitörleri ve Subklinik Hipotiroidizm

İyot yetersizliği ve buna bağlı olarak ortaya çıkan subklinik hipotiroidizm tüm dünyada önemli bir halk sağlığı sorunu olarak gündemdeki yerini korumaktadır. Özellikle gebeler, laktasyondaki genç anneler ve yaşlı kadınlar, ayrıca fetüs ve yeni doğanlar iyot yetersizliğine en duyarlı grupları oluşturmaktadır. Dünya Sağlık Örgütü WHO , 1990 yılından itibaren iyotlu tuz kullanımını, başta iyot yetersizliği sorunu bulunan ülkeler olmak üzere, tüm dünyaya önermiş ve desteklemiştir. İyot kullanımının yaygınlaşmasına rağmen iyot yetersizliği sorunu pek çok ülkede halen sürmektedir. Bu sorunun, iyot alımını engelleyen çevresel kimyasalların artışı ile ilişkili olabileceği düşünülmektedir. Bu nedenle bu makalede perklorik asit ve tiyosiyanat gibi iyot alımını engelleyen çevresel kimyasalların yaygınlaşması ve tiroid metabolizmasına etkileri konusunda bilgi vermek ve ülkemizde bu konuda farkındalık yaratmak hedeflenmiştir.

Environmental Goitrogens Nis Inhibitors and Subclinical Hypothyroidism

Iodine deficiency and subclinical hypothyroidism that develops as a result of this deficiency remain as significant problems of public health in the whole world. Pregnant, elderly or lactating women as well as fetuses and newborns constitute the groups most sensitive to iodine deficiency. The World Health Organization WHO supports the use of iodinised salt since 1990 in the whole world, and particularly in regions with iodine deficiency. However, despite the increase in the use of iodine, iodine deficiency remains as a significant problem in many countries. This problem might be related to the increase in the environmental chemicals that inhibits the iodine penetration. Therefore, this article studies the impact of the spread of environmental chemicals such as perchloric acid and thiocyanate on thyroid metabolism and aims to raise awareness on this issue in Turkey

Keywords:

perchloric acid, thiocyanate, nitrate, NIS inhibitors thyroid hormones,

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