Fatih ERMİŞ, Hilmi DEMİRİN, Mustafa ÖZŞAHİN, Taner UÇGUN, Özlem ADMIŞ, Safinaz ATAOĞLU

Neutrophil - lymphocyte ratio in patients with ankylosing spondylitis

Amaç: Bu çalışmanın amacı, ankilozan spondilit (AS) hastalarındaki inflamasyon ile nötrofil -lenfosit oranı (NLO)arasındaki ilişkiyi belirlemektir.Yöntem: Ankilozan spondilit tanılı 40 hasta ve 30 sağlıklıgönüllü çalışmaya dahil edildi. Tüm veriler yatan ve poliklinik hasta kayıt veritabanından elde edildi. Tüm olgularınBath Ankilozan Spondilit Hastalık Aktivite İndeksi (BA S-DAI), tam kan sayımı (TKS), CRP ve ESHı da kapsıyan ayrı ntılı fizik muayene ve laboratuvar bulguları kaydedildi.Lenfosit ve nötrofil sayısı otomatik TKSnin bir parçasıolarak ölçüldü.Bulgular : Akut-faz reaktanı olan CRP ve ESH kontrol gr ubuna göre hasta grubunda anlamlı olarak daha yüksekti (p0.05).Sonuç : Bu çalışmada NLO düzeylerinin AS hastalarındasağlıklı bireylere göre anlamlı olarak yüksek olmadığıgörüldü. Bu sonuç NLOnun AS hastalarında sistemik in flamasyonu değerlendirmede uygun bir ölçü birimi olmad ığını götermektedir. Bizim elde ettiğimiz bu ön sonuçlarındaha ileri çalışmalarla tamamlanması gerektiğine inanıyoruz.

Ankilozan spondilit hastalarında nötrofil- lenfosit oranı

Objective : The purpose of the present study is to determinethe association between neutrophil -lymphocyte ratio (NLR)and inflammation in ankylosing spondylitis (AS).Method : Forty patients with ankylosing spondylitis and 30healthy volunteers were included in the study. All data wereobtained from patient registry database from in -patient andout-patient clinics. Detailed physical examination, and BathAnkylosing Spondylitis Disease Activity Index (BASDAI) wererecord ed. Complete blood count (CBC), CRP and ESR wereperformed recorded as laboratory tests in all participants.Lymphocyte and neutrophil counts were measured as part ofthe automated CBC.Results : The CRP, which is an acute -phase reactant, and ESRwere signi ficantly higher in the patient group than those in thecontrol group (p0.05).Conclusion : We observed that NLR levels weren t significantlyhigher in AS patients compared to healthy individuals. NLRhasn t seem a reasonable measure to detect systemic infla m-mation in AS patients. We believe that our preliminary resultsneed to be complemented with further studies.

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